Parental Deprivation Induces N‐Methyl‐D‐Aspartate‐Receptor Upregulation in Limbic Brain Areas of <i>Octodon degus</i>: Protective Role of the Maternal Call

Ziabreva, Iryna; Schnabel, Reinhild; Braun, Katharina

doi:10.1155/np.2000.233

Cited by 16 publications

(12 citation statements)

References 31 publications

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“…In addition to the deficit in recall of extinction, briefly separated animals had reduced NR1 expression in layer VI of IL, whereas NR1 staining was unaltered in AC and PL, as well as in basolateral and central amygdala. Similarly, though maternal separation and isolation similarly failed to alter NMDA receptor binding in the amygdala of the 2 week old degus, it increased NMDA receptor binding in the mPFC in this precocial species (Ziabreva et al, 2000). Furthermore, our effect is consistent with recent findings that early postnatal shock exposure alters extinction of contextual fear conditioning in adults, and this effect is ameliorated by administration of an NMDA receptor facilitator during extinction (Matsumoto et al, 2008).…”

Section: Effects Of Maternal Separation On Nr1 Expressionsupporting

confidence: 90%

Brief neonatal maternal separation alters extinction of conditioned fear and corticolimbic glucocorticoid and NMDA receptor expression in adult rats

Wilber

Southwood

Wellman

2008

Developmental Neurobiology

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Neonatal maternal separation alters adult HPA axis responsiveness to stress, adult emotionality, and glucocorticoid receptor (GR) concentrations in forebrain regions such as hippocampus. To investigate effects of neonatal maternal separation on emotion regulation and its neural substrates, we assessed acquisition and extinction of conditioned fear in adult rats that underwent neonatal maternal separation. Corticolimbic structures including basolateral amygdala and medial prefrontal cortex are critical for acquisition and extinction of conditioned fear, and such learning is N-methyl-D-aspartic acid (NMDA) receptor-dependent. Thus, we used immunohistochemistry to assess expression of the GR and the NR1 subunit of the NMDA receptor in basolateral amygdala and medial prefrontal cortex. On postnatal days 2-14, pups underwent control rearing or maternal separation for 15 min per day. Fear conditioning and extinction in adulthood were then assessed in male rats. Rats received five tone-alone habituation trials, then seven tone/footshock pairings. After 1 h, rats received tone-alone extinction trials to criterion, and 15 recall of extinction trials the next day. Brains were processed for immunohistochemical labeling of GR and NR1, and staining was quantified. Brief maternal separation did not alter acquisition or initial extinction, but impaired extinction recall. Brief maternal separation did not alter GR or NR1 expression in basolateral amygdala. However, brief maternal separation increased GR and decreased NR1 expression specifically in the infralimbic region of medial prefrontal cortex, consistent with work implicating this area in extinction recall. Thus, brief maternal separation impaired extinction recall and altered GR and NR1 expression in its neural substrate in adults. '

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Section: Effects Of Maternal Separation On Nr1 Expressionsupporting

confidence: 90%

Brief neonatal maternal separation alters extinction of conditioned fear and corticolimbic glucocorticoid and NMDA receptor expression in adult rats

Wilber

Southwood

Wellman

2008

Developmental Neurobiology

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“…The impact of early neonatal stressors and postnatal exposure to synthetic glucocorticoid on NMDAR development has been determined. Repeated maternal deprivation in the South American precocial species, Octodon degus, led to the upregulation of NMDA receptor density in hippocampal regions CA1 and CA3 in offspring at 2 weeks of postnatal age [179]. In contrast, maternal deprivation in rats was associated with down-regulation of hippocampal NMDAR subunits NR2A and NR2B mRNA levels in adult offspring [180].…”

Section: Programming Of the Nmda Receptor Systemmentioning

confidence: 95%

RETRACTED: Maternal adversity, glucocorticoids and programming of neuroendocrine function and behaviour

Owen

Andrews

Matthews

2005

Neuroscience & Biobehavioral Reviews

196

148

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“…Compared to the control group, the separation group showed an upregulation of NMDA receptor density in the prefrontal cortex, hippocampus and amygdala. In the third group, presentation of the maternal call during the separation period suppressed the NMDA receptor upregulation in all brain regions . In a 2014 review, Bock et al summarised their work, and the work of others, to provide an integrative view on this topic.…”

Section: Resultsmentioning

confidence: 99%

Suboptimal bonding impairs hormonal, epigenetic and neuronal development in preterm infants, but these impairments can be reversed

et al. 2015

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Parental Deprivation Induces N‐Methyl‐D‐Aspartate‐Receptor Upregulation in Limbic Brain Areas of Octodon degus: Protective Role of the Maternal Call

Cited by 16 publications

References 31 publications

Brief neonatal maternal separation alters extinction of conditioned fear and corticolimbic glucocorticoid and NMDA receptor expression in adult rats

Brief neonatal maternal separation alters extinction of conditioned fear and corticolimbic glucocorticoid and NMDA receptor expression in adult rats

RETRACTED: Maternal adversity, glucocorticoids and programming of neuroendocrine function and behaviour

Suboptimal bonding impairs hormonal, epigenetic and neuronal development in preterm infants, but these impairments can be reversed

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