Parental consanguinity increases congenital heart diseases in South India

Abstract

Therefore, for every incidence of parental consanguinity, the risk (odds) of birth of a child with CHD increases. There is an urgent need to educate the public on the deleterious effects of inbreeding, especially in India, which has high overall consanguinity.

Exclusion of chromosomal abnormalities and microdeletions 22q11 and 10p13 in algerian patients with isolated conotruncal malformation

“…Interestingly, our present study showed a significant correlation between consanguinity and congenital heart disorders (P = 0,014). These results are in agreement with results reported Saudi Arabia [44], in Lebanon, [45] or in India [46]. Our results are emphasize the important role played by the segregation of recessive genes in the offspring in the etiology of CHD, there is an urgent need to educate the public about the deleterious effects of inbreeding, particularly in Algeria as in Arab populations, where the ratio of consanguineous marriage is very high.…”

An Assessment of Risk Factors for Congenital Heart Diseases in Children of Age Group 0 - 10 Years : A Case Control Study

“…(7,11) In our study VSD was the most common cardiac anomaly seen in 39(52%) cases, followed by Cyanotic heart diseases, ASD and PDA and results were comparable to previous studies. (4,6,9) In the neonatal characteristics, low birth weight was found in 45(60%) cases in our study, which was higher as compared to 23% cases in a study by faheem Ul Haq. (6) Of the various risk factors observed in our study, 26(35%) children were born of consanguineous marriage, while in a similar study done by Faheem Ul Haq et al found it in 49% cases (6) and Smitha et al 40.28%.…”

Is Consanguineous Marriage Responsible for Congenital Cardiac and Extra-Cardiac Anomalies?

“…Uncleniece marriage is not present in Arabs and religiously it is forbidden in Islam and Muslim's populations. 13 In this study, we found almost 10 times higher congenital anomalies both cardiac and extracardiac, probably because in South India uncle-niece marriage is very common. First cousin marriages also were the most common recorded consanguinity and the risk of developing congenital cardiac anomalies in babies born from first cousin parents when compared with non-related parents was 4 times higher and 3 times higher in babies born from far related parents.…”