“…A study showed that offspring of consanguineous couples had a more than 4 times higher risk of having congenital anomalies, compared with those of non-consanguineous couples. In addition, parental consanguinity significantly increased the risk of developmental delay, autism, and the prevalence of structural malformations such as cardiovascular, musculoskeletal, and urological systems compared with nonconsanguineous couples [4]. In addition, consanguineous marriage is found to be associated with an increased risk for autosomal recessive diseases [5], such as betathalassemia major [4,6], cystic fibrosis, and Tay-Sachs disease [6], a deficiency of hydrolase β-hexosaminidase.…”