Parental age as a risk factor in Alzheimer's disease

Corkin, Suzanne; Growdon, John H.; Rasmussen, Shelley L.

doi:10.1002/ana.410130618

Cited by 37 publications

(14 citation statements)

References 5 publications

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“…To date, four stud-ies have reported such an association [4,29,44,451 and five have not [46][47][48][49][50]. Our study was also unable to replicate this finding, although fathers of patients were an average of 2 years older than fathers of control subjects; the statistical significance of this finding was suggestive ( p = 0.12).…”

Section: Parental Agecontrasting

confidence: 79%

A case‐control study of Alzheimer's disease

Graves

White

Koepsell

et al. 1990

Annals of Neurology

202

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A case-control study of Alzheimer's disease (AD) was conducted to evaluate the roles of family history of dementing disease and AD, and medical conditions, particularly those related to the viral and immune hypotheses in AD. One hundred and eighty-three clinically diagnosed patients were identified between 1980 and 1985 through the Geriatric and Family Services clinic at the University of Washington hospital, and 18 patients were identified during the same time period through the Veteran's Administration Medical Center in Seattle, Washington. Telephone interviews were conducted with spouses (87.7%) and children (12.3%) of the patients. Each patient was matched to a friend or nonblood relative of the patient by age, sex, and the relationship between the patient and his or her respondent, for a total of 130 matched pairs. The odds ratio for AD was elevated if a first-degree relative was reported to have a history of dementia (odds ratio, 2.21; 95% confidence interval, 1.17 to 4.18). This risk was especially elevated if a sibling was affected (odds ratio, 4.04; 95% confidence interval, 1.37 to 11.90); the highest risk to the proband was observed if a sibling had presumed AD (odds ratio, 5.92; 95% confidence interval, 1.59 to 21.96). The risk increased with increasing numbers of first-degree family members affected for both a history of dementia and presumed AD. We found little difference between patients and control subjects with respect to the age of the mother or father at the time of the subject's birth. No statistically significant differences were observed between the two groups with regard to conditions that might support the immune and viral hypothesis in AD, smoking, or alcohol problems.

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Section: Parental Agecontrasting

confidence: 79%

A case‐control study of Alzheimer's disease

Graves

White

Koepsell

et al. 1990

Annals of Neurology

202

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“…The results of our study indicated the mean ages of the parents of AD patients and nondemented control subjects at the time of births did not differ, in accord with other groups' findings [15,20].…”

Section: Epidemiological Aspectssupporting

confidence: 79%

Clinical and Epidemiological Aspects of Alzheimer's Disease with Presenile Onset: A Case Control Study

et al. 1990

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Little is known regarding the pathogenetic factors for Alzheimer''s disease (AD). We studied 63 AD patients in order to evaluate if there were clinical subtypes of AD and whether prior illnesses and life-styles were involved in the development of the disease. In our patients selected for onset of symptoms before age 65 we did not find any significant clinical heterogeneity. Furthermore, we found no data in the medical history that are predictive for the development of presenile AD but observed a significantly increased frequency of dementia in the families of AD patients in comparison to controls.

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“…This study also showed that high birth order was more frequent in patients than in controls (even though the measure of association did not reach statistical significance). Other studies, however, found no association between advanced age of the mother at subject's birth and occurrence of AD (14,171.…”

Section: Ns S Ns Smentioning

confidence: 97%

Epidemiology of clinically diagnosed Alzheimer's disease

Rocca

Amaducci

Schoenberg

1986

Annals of Neurology

268

112

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This report reviews the current status of descriptive and analytic epidemiology of clinically diagnosed Alzheimer's disease (AD). Since AD can be diagnosed with certainty only at autopsy, currently available epidemiological data are based on a presumed clinical diagnosis. Current data indicate that AD represents a major health problem, at least in the developed countries. The prevalence ratio for AD ranges between 1.9 and 5.8 cases per 100 population aged 65 and over. Moreover, its prevalence is likely to increase in the next twenty years as a consequence of current demographic trends. The prevalence ratio for AD increases steeply with age and is higher in females. Incidence rates show a similar pattern, suggesting that AD should not be subdivided in a presenile and a senile form based on age of onset alone. Annual incidence rates of 2.4 cases per 100,000 population between ages 40 and 60, and 127 cases per 100,000 population after age 60 have been reported. Several case-control studies show that the occurrence of either dementia or Down's syndrome in other family members, advanced age of the mother at subject's birth, and head injury are possible risk factors.

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Parental age as a risk factor in Alzheimer's disease

Abstract: Alzheimer's disease is the most common type of dementia, and it is characterized by a decline in memory or other thinking skills.

Cited by 37 publications

References 5 publications

A case‐control study of Alzheimer's disease

A case‐control study of Alzheimer's disease

Clinical and Epidemiological Aspects of Alzheimer's Disease with Presenile Onset: A Case Control Study

Epidemiology of clinically diagnosed Alzheimer's disease

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