Parentʼs Age and the Risk of Oral Clefts

Bille, Camilla; Skytthe, Axel; Vach, Werner; Knudsen, Lisbeth B.; Andersen, Anne‐Marie Nybo; Murray, Jeffrey C.; Christensen, Kaare

doi:10.1097/01.ede.0000158745.84019.c2

Cited by 121 publications

(103 citation statements)

References 28 publications

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“…Nonetheless, children of older fathers are not only more likely to have several diseases of clear genetic cause (Kühnert and Nieschlag, 2004;Lambert et al, 2006), they show also an increased risk for multifactorial diseases such as birth defects (Olshan et al, 1994;McIntosh et al, 1995;Kazaura et al, 2004;Bille et al, 2005;Zhu et al, 2005a, b;Archer et al, 2007;Yang et al, 2007), childhood cancers (Moll et al, 1996;Hemminki et al, 1999;Sharpe et al, 1999;Murray et al, 2002;Yip et al, 2006), prostate cancer (Zhang et al, 1999), breast cancer (controversial) (Colditz et al, 1991;Choi et al, 2005), diabetes mellitus type l (Bingley et al, 2000;Cardwell et al, 2005), multiple sclerosis (Montgomery et al, 2004), some forms of cerebral palsy (Fletcher and Foley, 1993), schizophrenia (Malaspina, 2001), bipolar disorder (Frans et al, 2008), autism (Reichenberg et al, 2006), epilepsy (Vestergaard et al, 2005), Alzheimer disease (Whalley et al, 1995) and lower intelligence quotients (Malaspina et al, 2005;Saha et al, 2009). However, some of the reported associations need to be considered with caution for methodological reasons in the statistical analysis, especially in regard to the validity of the data sources (Kirby, 2007) (Fig.…”

Section: Paternal Age and Outcome Of Offspringmentioning

confidence: 99%

Paternal age and reproduction

Sartorius

Nieschlag

2009

Human Reproduction Update

289

212

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background: Due to various sociological factors, couples in developed countries are increasingly delaying childbearing. Besides ethical, economical and sociological issues, this trend presents us with several complex problems in reproduction. Although it is well-known that maternal age has a negative effect on fertility and increases the risk of adverse outcome during pregnancy and in offspring, the paternal influence on these outcomes is less well researched and not well-known.methods: We performed a systematic search of PubMed, and retrieved original articles and review articles to update our previous survey in this journal.results: This review highlights the link between male age and genetic abnormalities in the germ line and summarizes the knowledge about the effects of paternal age on reproductive function and outcome. Increasing paternal age can be associated with decreasing androgen levels, decreased sexual activity, alterations of testicular morphology and a deterioration of semen quality (volume, motility, morphology). Increased paternal age has an influence on DNA integrity of sperm, increases telomere length in spermatozoa and is suggested to have epigenetic effects. These changes may, at least in part, be responsible for the association of paternal age over 40 years with reduced fertility, an increase in pregnancy-associated complications and adverse outcome in the offspring. conclusion: Although higher maternal age can be an indication for intensive prenatal diagnosis, including invasive diagnostics, consideration of the available evidence suggests that paternal age itself, however, provides no rationale for invasive procedures.

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Section: Paternal Age and Outcome Of Offspringmentioning

confidence: 99%

Paternal age and reproduction

Sartorius

Nieschlag

2009

Human Reproduction Update

289

212

View full text Add to dashboard Cite

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“…31 A higher age of the mother is considered a risk factor for several chromosomal and non-chromosomal abnormalities; there is, however, no consensus as to whether maternal age is a risk factor for CLP. 33 In our sample only one father was aged 41 to 45 years ( Table 2). A study of 100 children with CLP revealed that maternal age was significant for the occurrence of clefts, and that ages 26 to 35 years and over 35 years had a lower risk for CLP compared to women aged up to 25 years.…”

Section: Discussionmentioning

confidence: 97%

Estudo de pacientes com fissuras lábio-palatinas com pais consanguíneos

Aquino¹,

Paranaíba²,

Martelli³

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

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Cl eft lip and/or palate (CL/P) are the most common congenital anomalies of the face. CL/P are non-syndromic (CL/PNS) in about 70% of subjects. Aim:To describe clinical cases of non-syndromic CL/P (CL/PNS) associated with consanguinity, diagnosed at a reference hospital in Minas Gerais, Brazil, and to correlate these alterations with possible risk factors. Series and Methods:A retrospective study at a reference hospital for craniofacial deformities in Minas Gerais, Brazil from 2006 to 2009 based on data in medical records. Results:Of 246 CL/PNS cases diagnosed and treated at the institution, 15 (6.1%) were CL/PNS with reported first-degree consanguinity; 73.3% occurred in males. Four of 15 patients had complete right cleft palate and lip (CLP), 4 presented complete cleft palate and lip (right and left), 3 had complete unilateral left CLP, 3 had isolated cleft palate, and 1 presented cleft lip only. Among the risk factors, only three mothers reported smoking during pregnancy.Conclusions: CLP (unilateral or bilateral) were more frequent in the group with a history of firstdegree consanguinity; males predominated. Among the risk factors, only smoking was observed in three cases.

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“…Other studies have shown that older, rather than younger, mothers are more at risk of having children with cleft (e.g., Bille et al 2005). However, a higher risk among mothers under age 20 than among those aged 25-29 has been reported in the literature (Croen and Shaw 1995).…”

Section: Discussionmentioning

confidence: 98%

“…The epidemiologic literature dealing with the effects of the ages of both parents on congenital anomalies more or less confirms these results. In one study (Bille et al 2005), both a high maternal age and a high paternal age were found to be associated with the occurrence of cleft lip with or without cleft palate, while a higher paternal age, but not a higher maternal age, was shown to increase the risk of having a child with cleft palate only. A Norwegian study confirmed the effect of the father's age, but not of the mother's age, on the incidence of cleft palate (Harville et al 2007).…”

Section: Introductionmentioning

confidence: 97%