Parent–progeny recognition as a function of MHC odortype identity

Yamazaki, Kunio; Beauchamp, Gary K.; Curran, Maryanne; Bard, Judith; Boyse, Edward A.

doi:10.1073/pnas.180320997

Cited by 120 publications

(98 citation statements)

References 36 publications

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“…For example, Hager & Johnstone (2005) found differential growth of own and alien pups in a mixed litter, which could be due to preferential nursing or retrieval of own pups by mothers (e.g. Yamazaki et al 2000). Alternatively, pups nursed by unrelated mothers may be less effective in solicitation behaviour and separation from the cage in which pups are born may result in a 'home-cage advantage' of pups reared by their own mothers.…”

Section: Discussionmentioning

confidence: 99%

Change in maternal environment induced by cross-fostering alters genetic and epigenetic effects on complex traits in mice

2009

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The interaction between maternally provided environment and offspring genotype is a major determinant of offspring development and fitness in many organisms. Recent research has demonstrated that not only genetic effects, but also epigenetic effects may be subject to modifications by the maternal environment. Genomic imprinting resulting in parent-of-origin-dependent gene expression is among the best studied of epigenetic effects. However, very little is known about the degree to which genomic imprinting effects can be modulated by the maternally provided environment, which has important implications for phenotypic plasticity. In this study, we investigated this unresolved question using a cross-fostering design in which mouse pups were nursed by either their own or an unrelated mother. We scanned the entire genome to search for quantitative trait loci whose effects depend on cross-fostering and detected 10 of such loci. Of the 10 loci, 4 showed imprinting by cross-foster interactions. In most cases, the interaction effect was due to the presence of an effect in either cross-fostered or non-cross-fostered animals. Our results demonstrate that genomic imprinting effects may often be modified by the maternal environment and that such interactions can impact key fitness-related traits suggesting a greater plasticity of genomic imprinting than previously assumed.

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Section: Discussionmentioning

confidence: 99%

Change in maternal environment induced by cross-fostering alters genetic and epigenetic effects on complex traits in mice

2009

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“…Evidence from mice suggests that MHC may be involved in such kin discrimination. Female mice prefer to nest with partners that share MHC alleles [18] and retrieve pups that are genetically identical to themselves in preference to those differing only at the MHC [19].…”

Section: Introductionmentioning

confidence: 99%

Odour signals major histocompatibility complex genotype in an Old World monkey

et al. 2010

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The major histocompatibility complex (MHC) is an extraordinarily diverse cluster of genes that play a key role in the immune system. MHC gene products are also found in various body secretions, leading to the suggestion that MHC genotypes are linked to unique individual odourtypes that animals use to assess the suitability of other individuals as potential mates or social partners. We investigated the relationship between chemical odour profiles and genotype in a large, naturally reproducing population of mandrills, using gas chromatography-mass spectrometry and MHC genotyping. Odour profiles were not linked to the possession of particular MHC supertypes. Sex influenced some measures of odour diversity and dominance rank influenced some measures of odour diversity in males, but not in females. Odour similarity was strongly related to similarity at the MHC, and, in some cases, to pedigree relatedness. Our results suggest that odour provides both a cue of individual genetic quality and information against which the receiver can compare its own genotype to assess genetic similarity. These findings provide a potential mechanism underlying mate choice for genetic diversity and MHC similarity as well as kin selection.

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“…Hybrid F1 mice (B6C and CB6) shared 50% of genes, whereas inbred F1 mice (B6B6 for B6 father, CC for BALB/ c father) shared 100% of genes, which would lead to differences in paternal but not in maternal care. Female mice parents can distinguish the odor of their own pups according to the differences in genes related to the major histocompatibility complex [35]. Other possibilities that create differences in male-female relationships, and in pups' attachment behavior that is so key in inducing parental behavior, should be also taken into consideration.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Parental Behavior and Offspring's Anxiety Behavior Using a Reciprocal F1 Hybrid Model

Ozawa

Kikusui

Takeuchi

et al. 2010

The Journal of Veterinary Medical Science

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ABSTRACT. Emotional behavior can be characterized by interactions between genes and environments, especially in the developmental period. However, in mice, the effects of paternal care on offspring's emotional development are not well understood even in cases in which the male mice show stable paternal care to the pups. In this study, we used a reciprocal hybrid model of C57BL/6 and BALB/c mice, which show different parental behaviors and emotional responses, and compared the emotional responses in pups in their adulthood by using the elevated plus-maze test. It was found that inbred male mice showed intensive parental behavior toward their pups, especially as parental contact behavior, and that the licking/grooming behavior of males was dependent on the strain of the female they were paired with. Also, BALB/c pairs showed less parental contact behavior than C57BL/6 pairs. In the elevated plus-maze test, BALB/c males and females showed higher anxiety behavior, and reciprocal hybrid offspring showed intermediate values between C57BL/6 and BALB/ c mice. Although no significant difference was found in the parental care that offspring received and anxiety-related behavior between the two reciprocal hybrid strains, BALB/c pairs showed less parental contact behavior toward the pups as compared to C57BL/6 pairs, which would be associated with the higher anxiety-related behavior exhibited in the adulthood of BALB/c strain.KEY WORDS: anxiety, maternal care, mice, paternal care, reciprocal F1 hybrid.J. Vet. Med. Sci. 72(12): 1589-1596, 2010 Social environments during the early stages of life, in addition to genetic variations, have long-lasting influences on the behavioral development of individuals. The motherpup interaction has especially strong influences on the behavioral characteristics of rodent offspring in their adulthood [6,26]. For example, anxiety and maternal behavior are associated with maternal care offspring received in their infant period [8,27]. Another thing is that maternally deprived pups show persistent stress-endocrine response, suggesting deficiencies in their negative feedback system [32]. We have shown that early weaned mice and rats deprived of maternal care in the neonatal period as well as in the postnatal period of day 15 to day 21 display reduced maternal behavior [23] and increased anxiety-related behavior [20,21]. Classic studies in mice kept in semi-natural environments showed bi-parental care and monogamous breeding colonies [9, 31], indicating that not only maternal care, but also paternal care comprises important social stimuli for the developing pups. It is unfortunate that the effects of paternal care on the behavioral development of offspring have not been well documented.The genetic influences on behavioral development have been well demonstrated. Some studies have assessed genomic influences on behavior using hybrid F1 mice. For example, offspring from different genetic strains showed different levels of anxiety even though they received mothering from a mother of the same strain [...

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Parent–progeny recognition as a function of MHC odortype identity

Cited by 120 publications

References 36 publications

Change in maternal environment induced by cross-fostering alters genetic and epigenetic effects on complex traits in mice

Change in maternal environment induced by cross-fostering alters genetic and epigenetic effects on complex traits in mice

Odour signals major histocompatibility complex genotype in an Old World monkey

Comparison of Parental Behavior and Offspring's Anxiety Behavior Using a Reciprocal F1 Hybrid Model

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