“…205 Evidence that the target symptoms are interfering substantially with learning/academic progress, socialization, health/safety (of the patient and/or others around him or her), or quality of life Suboptimal response to available behavioral interventions and environmental modifications Research evidence that the target behavioral symptoms or coexisting psychiatric diagnoses are amenable to pharmacologic intervention Choose a medication on the basis of Likely efficacy for the specific target symptoms Potential adverse effects Practical considerations such as formulations available, dosing schedule, cost, and requirement for laboratory or electrocardiographic monitoring Informed consent (verbal or written) from parent/guardian and, when possible, assent from the patient Establish plan for monitoring of effects Identify outcome measures Discuss time course of expected effects Arrange follow-up telephone contact, completion of rating scales, reassessment of behavioral data, and visits accordingly Outline a plan regarding what might be tried next if there is a negative or suboptimal response or to address additional target symptoms Change to a different medication Add another medication to augment a partial or suboptimal therapeutic response to the initial medication (same target symptoms) Add a different medication to address additional target symptoms that remain problematic Obtain baseline laboratory data if necessary for the drug being prescribed and plan appropriate follow-up monitoring Explore the reasonable dose range for a single medication for an adequate length of time before changing to or adding a different medication Monitor for adverse effects systematically Consider careful withdrawal of the medication after 6-12 mo of therapy to determine whether it is still needed Another recent parent survey found that 52% of the children with an ASD had been treated with at least 1 CAM therapy, compared with 28% of a group of control children without disabilities. 207 Surveys indicate that only 36% to 62% of caregivers who used CAM therapies for their children with ASDs had informed the child's primary care physician, 207,208 although more information on CAM is something that families indicate that they want from their child's primary health care professionals. 209 It is important that health care professionals understand how to evaluate the evidence used to support all treatments, including CAM, psychopharmacologic, and other interventions.…”