Parent-of-origin has no detectable effect on survival days of Marek's disease virus infected White Leghorns

Bai, Hao; He, Yanghua; Ding, Yi; Chang, Shuang; H, Zhang; Chen, J; Song, Jiuzhou

doi:10.3382/ps/pez209

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…MDV can serve as a model to assess herpesviruses evolution [96] and to test pan-herpesvirus antiviral drugs [105]. Finally, researchers should further investigate the genetic resistance of the host to MDV infections [106][107][108][109]. In addition to conventional breeding programs, novel technology, including CRISPR/Cas9 genomic editing, could be used to generate more resistant chickens [110].…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

Latest Insights into Marek’s Disease Virus Pathogenesis and Tumorigenesis

Bertzbach

Conradie

You

et al. 2020

Cancers

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Marek’s disease virus (MDV) infects chickens and causes one of the most frequent cancers in animals. Over 100 years of research on this oncogenic alphaherpesvirus has led to a profound understanding of virus-induced tumor development. Live-attenuated vaccines against MDV were the first that prevented cancer and minimized the losses in the poultry industry. Even though the current gold standard vaccine efficiently protects against clinical disease, the virus continuously evolves towards higher virulence. Emerging field strains were able to overcome the protection provided by the previous two vaccine generations. Research over the last few years revealed important insights into the virus life cycle, cellular tropism, and tumor development that are summarized in this review. In addition, we discuss recent data on the MDV transcriptome, the constant evolution of this highly oncogenic virus towards higher virulence, and future perspectives in MDV research.

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