Parent-delivered touchscreen intervention for children with fragile X syndrome

Díez-Juan, María; Schneider, Andrea; Phillips, Tiffany; Lozano, Reymundo; Tassone, Flora; Solomon, Marjorie; Hagerman, Randi J.

doi:10.5582/irdr.2014.01026

Cited by 9 publications

(12 citation statements)

References 36 publications

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“…Apps have proven popular ( Clark et al, 2014 ) and case-series designs have revealed promising uses of these technologies (e.g. Díez-Juan et al, 2014 ). Our study does not refute these findings but does indicate that the impact of an app on behaviour may have its limits, and caution should be applied when recommending technology-based supports for this population.…”

Section: Discussionmentioning

confidence: 99%

“…The advent of touchscreen tablets (such as the iPad ™ ) means that we can now explore the delivery of therapeutic and educational content to very young children using technology ( Díez-Juan et al, 2014 ; Kagohara et al, 2013 ; Murdock et al, 2013 ). This approach brings together the belief in early intervention as the best opportunity for children with ASD ( Wallace and Rogers, 2010 ) with the specific advantages of technology.…”

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confidence: 99%

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A trial of an iPad^™ intervention targeting social communication skills in children with autism

Fletcher‐Watson

Petrou

Scott-Barrett

et al. 2016

Autism

121

100

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This study evaluated a technology-based early intervention for social communication skills in pre-schoolers in a randomised controlled trial. Participants were 54 children aged under 6 years with a diagnosis of autism, assigned to either intervention or control conditions. The app engaged children, who played consistently, regardless of developmental level, and was rated highly by parents. There were no significant group differences in parent-report measures post-intervention, nor in a measure of parent–child play at follow-up. Therefore, this intervention did not have an observable impact on real-world social communication skills and caution is recommended about the potential usefulness of iPad™ apps for amelioration of difficulties in interaction. However, positive attitudes among participants, lack of harms and the potential of apps to deliver therapeutic content at low economic cost suggest this approach is worth pursuing further, perhaps targeting other skill domains.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

A trial of an iPad^™ intervention targeting social communication skills in children with autism

Fletcher‐Watson

Petrou

Scott-Barrett

et al. 2016

Autism

121

100

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“…In conclusion, touchscreen tasks for mouse models of neurodevelopmental disorders with intellectual disabilities offer advantages in designing tasks that allow the researcher to titrate the demands on working memory and evaluate various cognitive domains, using equipment similar to that used in human subjects with intellectual disabilities ( Green et al, 2009 ; Van der Molen et al, 2010 ; van Nieuwpoort et al, 2011 ; Berry-Kravis et al, 2013 ; Díez-Juan et al, 2014 ). Our findings with a new touchscreen DNMTP task revealed that Fmr1 mutant mice on the FVB/AntJ background performed as well as their WT controls on a delay-dependent working memory task.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, touchscreen behavioral testing equipment ideal for evaluating complex learning and memory in rodents was introduced by Bussey et al (2001) at the University of Cambridge and rigorously validated in mice by Brigman and Rothblat (2008) and others ( Bussey et al, 2012 ; Mar et al, 2013 ; Oomen et al, 2013 ; Graybeal et al, 2014 ). Visually based, touch-sensitive technology in operant chambers is similar to cognitive testing designs in higher-order species, including nonhuman primates and humans ( Green et al, 2009 ; Van der Molen et al, 2010 ; van Nieuwpoort et al, 2011 ; Berry-Kravis et al, 2013 ; Díez-Juan et al, 2014 ). Investigations using mouse touchscreen chambers have recently been published by several behavioral neuroscience laboratories ( Brigman et al, 2005 ; Talpos et al, 2010 ; Graybeal et al, 2011, 2014 ; Romberg et al, 2011 ; Bussey et al, 2012 ; Silverman et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Normal Performance of Fmr1 Mice on a Touchscreen Delayed Nonmatching to Position Working Memory Task

Leach

Hayes

Pride

et al. 2016

eNeuro

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Fragile X syndrome is a neurodevelopmental disorder characterized by mild-to-severe cognitive deficits. The complete absence of Fmr1 and its protein product in the mouse model of fragile X (Fmr1 KO) provides construct validity. A major conundrum in the field is the remarkably normal performance of Fmr1 mice on cognitive tests in most reports. One explanation may be insufficiently challenging cognitive testing procedures. Here we developed a delayed nonmatching to position touchscreen task to test the hypothesis that paradigms placing demands on working memory would reveal robust and replicable cognitive deficits in the Fmr1 KO mouse. We first tested Fmr1 KO mice (Fmr1) and their wild-type (WT) littermates in a simple visual discrimination task, followed by assessment of reversal learning. We then tested Fmr1 and WT mice in a new touchscreen nonmatch to position task and subsequently challenged their working memory abilities by adding delays, representing a higher cognitive load. The performance by Fmr1 KO mice was equal to WTs on both touchscreen tasks. Last, we replicated previous reports of normal performance by Fmr1 mice on Morris water maze spatial navigation and reversal. These results indicate that, while the Fmr1 mouse model effectively recapitulates many molecular and cellular aspects of fragile X syndrome, the cognitive profile of Fmr1 mice generally does not recapitulate the primary cognitive deficits in the human syndrome, even when diverse and challenging tasks are imposed.

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“…In scenarios where the child(ren) experienced tantrums, were less emotionally regulated, or had difficulties staying in the same position for some duration of time, the caregiver's ability to participate was negatively affected. 52 , 67 – 71 Furthermore, the child's comfort with technology and with their home environment was reported to reduce anxieties associated with participating in appointments. 72 , 73 …”

Section: Resultsmentioning

confidence: 99%

Barriers and facilitators to paediatric caregivers’ participation in virtual speech, language, and hearing services: A scoping review

DiFabio,

Moodie,

O’Hagan

et al. 2023

DIGITAL HEALTH

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Purpose Virtual care-related technologies are transforming the way in which health services are delivered. A growing number of studies support the use of virtual care in the field of audiology and speech-language pathology; however, there remains a need to identify and understand what influences caregiver participation within the care that is virtual and family-focused. This review aimed to identify, synthesize, and summarize the literature around the reported barriers and facilitators to caregiver participation in virtual speech/hearing assessment and/or intervention appointments for their child. Methods A scoping review was conducted following the Joanna Briggs Institute manual for evidence synthesis. A search was conducted using six databases including MEDLINE, CINAHL, SCOPUS, ERIC, Nursing and Allied Health, and Web of Science to collect peer-reviewed studies of interest. Data was extracted according to a protocol published on Figshare, outlining a predefined data extraction form and search strategy. Results A variety of service delivery models and technology requirements were identified across the 48 included studies. Caregiver participation was found to vary across levels of attendance and involvement according to eight categories: Attitudes, child behavioral considerations, environment, opportunities, provider-family relationship, role in care process, support, and technology. Conclusions This review presents a description of the key categories reported to influence caregiver participation in virtual care appointments. Future research is needed to explore how the findings can be used within family-centered care models to provide strategic support benefiting the use and outcomes of virtual care.

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Parent-delivered touchscreen intervention for children with fragile X syndrome

Cited by 9 publications

References 36 publications

A trial of an iPad^™ intervention targeting social communication skills in children with autism

A trial of an iPad^™ intervention targeting social communication skills in children with autism

Normal Performance of Fmr1 Mice on a Touchscreen Delayed Nonmatching to Position Working Memory Task

Barriers and facilitators to paediatric caregivers’ participation in virtual speech, language, and hearing services: A scoping review

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Parent-delivered touchscreen intervention for children with fragile X syndrome

Cited by 9 publications

References 36 publications

A trial of an iPad™ intervention targeting social communication skills in children with autism

A trial of an iPad™ intervention targeting social communication skills in children with autism

Normal Performance of Fmr1 Mice on a Touchscreen Delayed Nonmatching to Position Working Memory Task

Barriers and facilitators to paediatric caregivers’ participation in virtual speech, language, and hearing services: A scoping review

Contact Info

Product

Resources

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A trial of an iPad^™ intervention targeting social communication skills in children with autism

A trial of an iPad^™ intervention targeting social communication skills in children with autism