Parenchymal leiomyoma of the breast. Report of a case and clinicopathological review

Tamir, Gabriel; Yampolsky, I.; Sandbank, Judith

doi:10.1016/s0748-7983(05)80077-0

Cited by 17 publications

(17 citation statements)

References 3 publications

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“…S-100 protein and cytokeratin stains were negative. The histogenesis of breast leiomyoma remains unclear and controversial [14,17,19,23]. The smooth muscle cells of the blood vessels of the breast are believed to most likely be the primary source of parenchymal leiomyomas [15,16,21].…”

Section: Discussionmentioning

confidence: 99%

Parenchymal leiomyoma of the breast: a case report with special reference to magnetic resonance imaging findings and an update review of literature

et al. 2011

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Parenchymal leiomyomas of the breast are extremely rare, with only 25 cases reported in the literature. We report the 26th case of parenchymal leiomyoma of the breast in a 63-year-old woman who presented to us with a right breast tumor detected on her screening mammography. This tumor was evaluated by mammography, ultrasonography, and MR imaging. To the best of our knowledge, this is the first case of a parenchymal leiomyoma of the breast examined by MR imaging. MR imaging revealed an oval mass with circumscribed margins that appeared as a high-intensity lesion in both T1 and T2. A dynamic MRI study showed a gradual increase pattern on the mass. Excisional biopsy revealed a growth pattern of interlacing fascicles of spindle cells without atypia or mitoses, consistent with parenchymal leiomyoma of the breast. Here we report a case of parenchymal leiomyoma of the breast, and describe the clinical, pathological, and immunohistochemical findings. In addition, we review the literature on parenchymal leiomyoma of the breast with regard to clinical characteristics and pathological features of this entity.

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Section: Discussionmentioning

confidence: 99%

Parenchymal leiomyoma of the breast: a case report with special reference to magnetic resonance imaging findings and an update review of literature

et al. 2011

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“…In patients with a confirmed diagnosis of breast leiomyoma, no cases of local recurrence have been reported to date. [11][12][13][14][15][16][17][18][19][22][23][24][25][26][27] We reviewed the literature in MEDLINE and Lilacs using the English keywords "leiomyoma", "fibroid tumors", "benign tumor", "benign neoplasms", "breast tumor", "breast neoplasms" and "ultrasonography". We found 30 case reports that described patients with leiomyoma in the breast parenchyma ( Table 2).…”

Section: Mmg = Mammogram Us = Ultrasonographymentioning

confidence: 99%

Leiomyoma of the breast parenchyma: a case report and review of the literature

et al. 2017

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INTRODUCTION: Benign tumors are often seen in breast screening examinations. However, the differential diagnosis is not always simple because of radiological similarity between the different benign lesions. CASE REPORT: We present a rare case report of leiomyoma of the breast parenchyma in a 68-year-old asymptomatic patient. The mammographic and ultrasonographic findings were similar to those observed in benign lesions. CONCLUSION: The histopathological diagnosis requires careful differentiation from lesions that have smooth muscle proliferation, especially leiomyosarcoma. The most commonly performed treatment is resection of the lesion with free margins. Although breast leiomyoma is rare, it should be considered among the differential diagnoses for breast nodules of benign appearance. Resection with safety margins proved to be the only treatment needed.

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“…These tumours are frequently found in the nipple and subareolar region and are extremely rare in the breast parenchyma. Since its initial description in 1913, fewer than 22 cases have been reported 1–5 …”

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confidence: 99%

“…4 These tumours arise as a hamartomatous proliferation of smooth muscle around blood vessel, from the embryonal migration of smooth muscle cells from the nipple, differentiate from multipotent mesenchymal cells in breast tissue or from myoepithelial cells of breast ducts. 5 The differential diagnosis includes benign fibrous breast lesions such as fibro-adenomas and cystosarcoma phylloides. 5 Histologically, these lesions show both epithelial and stromal components, whereas leiomyoma consists of only stromal element of smooth muscle differentiation.…”

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confidence: 99%

“…5 The differential diagnosis includes benign fibrous breast lesions such as fibro-adenomas and cystosarcoma phylloides. 5 Histologically, these lesions show both epithelial and stromal components, whereas leiomyoma consists of only stromal element of smooth muscle differentiation. It is difficult to differentiate stromal predominant cystosarcoma phylloides from leiomyomas, especially in trucut biopsies, and extensive sectioning and immunohistochemistry for the epithelial component will aid in the definitive diagnosis.…”

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confidence: 99%

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