Novel
asymmetric synthetic routes to (+)-uleine and (−)-tubifolidine
are reported herein. The regioselective formation of enol triflates
from 2-azabicyclo[3.3.1]nonane ketones followed by indolizations of
the resultant ene-hydrazides allowed the efficient construction of
key indole intermediates, facilitating the total synthesis of the
target natural alkaloids.