Parcellation-based modeling of the supplementary motor area

Sheets, John R.; Briggs, Robert G.; Young, Isabella M.; Bai, Michael Y.; Lin, Yueh‐Hsin; Poologaindran, Anujan; Conner, Andrew K.; O’Neal, Christen M.; Baker, Cordell M; Glenn, Chad A.; Sughrue, Michael E.

doi:10.1016/j.jns.2021.117322

Cited by 20 publications

(9 citation statements)

References 74 publications

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“…Of 180 brain parcellations described in the Glasser et al study, 7 4 were involved in the SMA 8 : the superior frontal language area, Brodmann area 6 medial anterior, Brodmann area 6 medial parietal, and the supplementary and cingulate eye field. The SMA is connected with the ipsi- and contralateral premotor areas for initiating movement.…”

Section: Discussionmentioning

confidence: 92%

“…A “crossed” FAT has also been described as a white matter tract that connects the SMA with the contralateral premotor area and SMA through the corpus callosum. This pathway explains bilateral hand-movement coordination of the SMA 8 , 24 and is suspected to be involved in neurological recovery during and after a temporary SMA syndrome. Compensation from the opposite hemisphere is a theory reinforced by research on functional connectivity, 25 with several studies reporting a surge in the level of activity of the contralateral SMA 26 , 27 when preserving the crossed FAT fibers.…”

Section: Discussionmentioning

confidence: 98%

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Connectomics as a prognostic tool of functional outcome in glioma surgery of the supplementary motor area: illustrative case

Molina

Tait

Ieva

2023

Journal of Neurosurgery: Case Lessons

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BACKGROUND The supplementary motor area (SMA) is essential in facilitating the commencement and coordination of complex self-initiated movements. Its complex functional connectivity poses a great risk for postoperative neurological deterioration. SMA syndrome can occur after tumor resection and comprises hemiakinesia and akinetic mutism (often, but unpredictably temporary). Although awake surgery is preferred for mapping and monitoring eloquent areas, connectomics is emerging as a novel technique to tailor neurosurgical approaches and predict functional prognosis, as illustrated in this case. OBSERVATIONS The authors report on a patient presenting with recurrent oligodendroglioma after subtotal resection 7 years earlier. After extensive neuropsychological and neuroradiological assessment (including connectomics), awake surgery was indicated. No intraoperative deficits were recorded; however, the patient presented with postoperative right-sided akinesia and mutism. Postoperative neuroimaging demonstrated the connectome overlapping the preoperative one, and indeed, neurological symptoms resolved after 3 days. LESSONS Comparison of the pre- and postoperative connectome can be used to objectively evaluate surgical outcomes and assess patient prognosis. To the best of the authors’ knowledge, this is the first case demonstrating the feasibility of quantitative functional connectivity analysis as a prognostic tool for neurological improvement after surgery. A better understanding of brain networks is instrumental for improving diagnosis, prognosis, and treatment of neuro-oncological patients.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Connectomics as a prognostic tool of functional outcome in glioma surgery of the supplementary motor area: illustrative case

Molina

Tait

Ieva

2023

Journal of Neurosurgery: Case Lessons

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“…While the interpretation of this aberrant connectivity remain elusive, further investigation is necessary to identify whether this functional connectivity may be related to specific symptoms not found in TD, may reflect a brain reorganization, or a spurious result. Across neuroimaging literature, the pINS appear to be implicated in processing sensory information (i.e., interoceptive processes, (Kurth et al, 2010 ; Tian & Zalesky, 2018 ), whereas the SMA is often linked to motor planning, sensory and memory tasks (Chung et al, 2005 ; Sheets et al, 2021 ), future studies should aim to examine the functional roles of these connectivity in the specific symptomatology of children with the secondary variant that may distinguish them from the primary variant.…”

Section: Discussionmentioning

confidence: 99%

Functional Connectivity of the Nucleus Accumbens across Variants of Callous-Unemotional Traits: A Resting-State fMRI Study in Children and Adolescents

Dugré,

Potvin

2023

Res Child Adolesc Psychopathol

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A large body of literature suggests that the primary (high callousness-unemotional traits [CU] and low anxiety) and secondary (high CU traits and anxiety) variants of psychopathy significantly differ in terms of their clinical profiles. However, little is known about their neurobiological differences. While few studies showed that variants differ in brain activity during fear processing, it remains unknown whether they also show atypical functioning in motivational and reward system. Latent Profile Analysis (LPA) was conducted on a large sample of adolescents (n = 1416) to identify variants based on their levels of callousness and anxiety. Seed-to-voxel connectivity analysis was subsequently performed on resting-state fMRI data to compare connectivity patterns of the nucleus accumbens across subgroups. LPA failed to identify the primary variant when using total score of CU traits. Using a family-wise cluster correction, groups did not differ on functional connectivity. However, at an uncorrected threshold the secondary variant showed distinct functional connectivity between the nucleus accumbens and posterior insula, lateral orbitofrontal cortex, supplementary motor area, and parietal regions. Secondary LPA analysis using only the callousness subscale successfully distinguish both variants. Group differences replicated results of deficits in functional connectivity between the nucleus accumbens and posterior insula and supplementary motor area, but additionally showed effect in the superior temporal gyrus which was specific to the primary variant. The current study supports the importance of examining the neurobiological markers across subgroups of adolescents at risk for conduct problems to precise our understanding of this heterogeneous population.

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“…lingual gyrus, lateral occipital cortex (Clarke & Miklossy, 1990)) to motor functions (i.e. supplementary motor area (Sheets et al, 2021)), somatosensory integration (i.e. parietal operculum (Eickhoff et al, 2006)), cognitive abilities (DLPFC (Murty et al, 2011), precentral, postcentral gyri, central operculum, hippocampus (Eichenbaum, 2000; Humphreys & Lambon Ralph, 2015; Padmala & Pessoa, 2010)) and emotion regulation (i.e.…”

Section: Discussionmentioning

confidence: 99%

Whole-brain structural and functional neuroimaging of individuals who attempted suicide and people who did not: a systematic review, exploratory coordinate-based meta-analysis and seed-based connectivity study

Meda

Miola

Cattarinussi

et al. 2022

Preprint

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IntroductionSuicide is the cause of death of approximately 800’000 people a year. Despite the relevance of this behaviour, risk assessment tools rely on clinician experience and subjective ratings.MethodsGiven that previous suicide attempts are the single strongest predictors of future attempts, we designed a systematic review and coordinate-based meta-analysis to evince if any neuroimaging features can help distinguish individuals who attempted suicide from subjects who did not. Out of 5659 publications from PubMed, Scopus and Web of Science, we summarised 102 experiments and meta-analysed 23 of them.ResultsA cluster in the right Superior Temporal Gyrus, a region implicated in emotional processing, might be functionally hyperactive in individuals who attempted suicide. Furthermore, we used JuSpace and the Human Brain Connectome dataset to show that this cluster is enriched in 5-HT1Aheteroreceptors, and its connectivity with the left central operculum is significantly correlated with loneliness scores.ConclusionsThis evidence provides a putative neural substrate for suicidal thought-to-attempt transition as hypothesised by Joiner’s Interpersonal Theory of Suicide. Heterogeneity in the analytical techniques and weak or absent power analysis of the studies included in this review currently limit the applicability of the findings, the replication of which should be prioritised.

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Parcellation-based modeling of the supplementary motor area

Cited by 20 publications

References 74 publications

Connectomics as a prognostic tool of functional outcome in glioma surgery of the supplementary motor area: illustrative case

Connectomics as a prognostic tool of functional outcome in glioma surgery of the supplementary motor area: illustrative case

Functional Connectivity of the Nucleus Accumbens across Variants of Callous-Unemotional Traits: A Resting-State fMRI Study in Children and Adolescents

Whole-brain structural and functional neuroimaging of individuals who attempted suicide and people who did not: a systematic review, exploratory coordinate-based meta-analysis and seed-based connectivity study

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