Paravertebral block using bupivacaine with/without fentanyl on postoperative pain after laparoscopic cholecystectomy: A double-blind, randomized, control trial

Abstract

Background:Postoperative pain is one of the most common complaints after elective laparoscopic cholecystectomy. The present study was aimed to evaluate the effect of paravertebral block using bupivacaine with/without fentanyl on postoperative pain and complications after laparoscopic cholecystectomy.Materials and Methods:This study was done on 90 patients scheduled to undergo elective laparoscopic cholecystectomy. Patients were assessed in two groups: The case group received bupivacaine and fentanyl, and the control group received bupivacaine and normal saline. Primary outcomes were severity of postoperative pain at rest and during coughing. Secondary outcomes were postoperative cumulative morphine consumption and the incidence of side-effects.Results:Pain score at rest before surgery, after recovery, hour-1 and hour-6 was not significantly different between the groups. But in hour-24 cases, the pain score during coughing was significantly higher than controls. Severity of pain at rest in time points was not different between groups. The frequencies (%) of moderate pain at mentioned times in case and control groups were 64, 31, 16, 9, 0 versus 67, 16, 7, 4, and 0, respectively. Pain score during coughing was lower in controls at hour-24 in comparison with cases, but in other time points was not significant. The control group significantly received more total dose of morphine in comparison with cases group. Nausea, vomiting and hypotension were similar in groups, but pruritus was significantly different between the groups.Conclusion:Adding fentanyl to bupivacaine in paravertebral block did not significantly improve the postoperative pain and complications after laparoscopic cholecystectomy. However, further studies are needed to be done.

Paravertebral block using levobupivacaine or dexmedetomidine-levobupivacaine for analgesia after cholecystectomy: a randomized double-blind trial

“…The efficacy of paravertebral block using local anesthetics with or without opioids has also been shown in previous studies. 25 However, none of the studies reported so far has evaluated the role of dexmedetomidine along with local anesthetics for giving thoracic PVB in laparoscopic cholecystectomy. In the present study, PVB was given to both groups, but used different combinations of drugs (levobupivacaine – dexmedetomidine/levobupivacaine) for administering the block, and found that the combination of levobupivacaine and dexmedetomidine when used for giving paravertebral block in laparoscopic cholecystectomy resulted in significant decrease in postoperative pain, as compared to using levobupivacaine alone.…”

Effect of erector spinae plane block on postoperative intravenous morphine consumption in open subcostal nephrectomy: A prospective randomized clinical trial

“…At the same time, relieving pain, preserving the cognitive functions of patients, and preventing the development of chronic pain are critical in terms of improving the quality of life. [1,2] The standard treatment for T 1 renal tumors is partial nephrectomy, and radical nephrectomy is also another standard treatment for T 2 tumors and localized masses not treatable by partial nephrectomy. Partial or radical nephrectomy can be performed with either open, laparoscopic, or robotic surgery.…”