Parathyroidectomy decreases neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios

Yang, Po‐Sheng; Liu, Chien‐Liang; Liu, Tsang-Pai; Chen, Han‐Hsiang; Wu, Chih‐Jen; Cheng, Shih‐Ping

doi:10.1016/j.jss.2017.12.016

Cited by 16 publications

(17 citation statements)

References 48 publications

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“…PLR and RDW values have been shown to be associated with the diagnosis and prognosis of several inflammatory disorders and malignancies [11,17,18]. In patients with secondary hyperparathyroidism, PLR and platelet count decreased after parathyroidectomy; however, these parameters were not significantly decreased in recurrent or persistent hyperparathyroidism [4].…”

Section: Discussionmentioning

confidence: 97%

“…This is explained as a cytokine-mediated change in the endocrine activity of parathyroid tumor cells [3]. Hyperparathyroidism increases systemic inflammation as a result of an abnormal calcium and phosphate mechanism [4]. PTH-lowering with calcitriol treatment decreased inflammation and contributed to lymphocyte modulation in patients undergoing hemodialysis with secondary hyperparathyroidism [20].…”

Section: Discussionmentioning

confidence: 99%

“…Inflammatory disorders in the endocrine glands are mostly associated with functional disorders [3]. Hyperparathyroidism increases systemic inflammation as a result of direct or indirect abnormal calcium and phosphate mechanisms [4]. Successful parathyroidectomy cures the clinic findings of PHP; however, the effect of parathyroidectomy on inflammation remains unclear [5].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Association between inflammatory markers and primary hyperparathyroidism

Beysel¹,

Çalışkan²,

Kızılgül³

et al. 2019

Acta Medica Alanya

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Amaç: Primer hiperparatiroidizm (PHP) sistemik inflamasyonla ilişkilidir. Paratiroidektominin (PTX) inflamatuar b elirteçler ü zerindeki e tkisi tartışmalıdır. Çalışmamızın amacı, PTX öncesi ve sonrası C-reaktif protein (hs-CRP), trombosit / lenfosit oranı (TLO) ve kırmızı hücre dağılım genişliğini (RDW) içeren inflamatuar belirteçlerdeki değişiklikleri araştırmaktı. Hastalar ve Yöntem: Çalışmaya PHP hastaları (n=55) ve yaş ve cinsiyet eşleştirilmiş sağlıklı kontroller (n=50) dahil edildi. PHP ve kontrol gruplarının klinik ve laboratuar sonuçları PTX'den önce ve PTX'den 6 ay sonra karşılaştırıldı.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association between inflammatory markers and primary hyperparathyroidism

Beysel¹,

Çalışkan²,

Kızılgül³

et al. 2019

Acta Medica Alanya

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“…Since the study was conducted retrospectively, written informed consent was not required. (2,7,8,10,11,12). As a result of this process, the neutrophil and platelet counts increase, while the lymphocyte count decreases.…”

Section: Patient Groupsmentioning

confidence: 99%

Platelet to Lymphocyte Ratio as a Predictive Biomarker for Preoperative Diagnosis of Parathyroid Adenoma

Aydın

Pehlivanli

2019

Kırıkkale Üniversitesi Tıp Fakültesi Dergisi

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Objective: There is a significant increase in studies concerning the use of platelet to lymphocyte ratio (PLR) and neutrophil to lymphocyte ratio (NLR) for diagnosis and prognosis in many inflammatory and malignant diseases. The idea that PLR and NLR can be used as a biomarker attracts many researchers to this area. The aim of this retrospective case control study was to investigate the role of PLR and NLR values in diagnosis of the parathyroid adenoma. Material and Methods: In this study, 17 patients with parathyroid adenoma (PAD group) were included and the PLR and NLR values of these patients were compared with control group (15 participants) consisted of healthy subjects. Results: The lymphocyte count values of the PAD group were significantly higher than those of the CONTROL group. The platelet count and NLR values were not different between the groups. The PLR values of the PAD group were significantly lower than those of the CONTROL groups. ROC-Curve analysis results showed that if platelet to lymphocyte ratio value was <125, it could be a specific and sensitive biomarker in discrimination of patients with parathyroid adenoma from healthy individuals. Conclusion: In conclusion, low PLR values measured in patients with primary hyperparathyroidism could be a new preoperative diagnostic biomarker for parathyroid adenoma. Amaç: Trombosit lenfosit oranı (PLR) ve nötrofilin lenfosit oranı (NLR) değerlerinin pekçok inflamatuvar ve malign hastalığın prognoz ve tanısında kullanımına yönelik çalışmalar her geçen gün artarak devam etmektedir. PLR ve NLR nin bir biyobelirteç olarak kullanılabilirliği fikri pek çok araştırmacının ilgisini bu alana çekmektedir. Bu retrospektif vaka kontrol çalışmasının amacı, PLR ve NLR değerlerinin paratiroid adenomu tanısındaki rolünü araştırmaktır. Gereç ve Yöntemler: Bu çalışmaya paratiroid adenomu olan 17 hasta (PAD grubu) dahil edildi ve bu hastalara ait PLR ve NLR değerleri sağlıklı bireylerden oluşan Kontrol grubu (15 katılımcı) değerleri ile karşılaştırıldı. Bulgular: PAD grubunun lenfosit sayım değerleri CONTROL grubundan anlamlı derecede yüksekti. Trombosit sayısı ve NLR değerleri gruplar arasında farklı değildi. PAD grubunun PLR değerleri Kontrol grubundakilerden anlamlı derecede düşüktü. ROC-Curve analizi sonuçları, trombosit lenfosit oranı değeri <125 olduğunda, paratiroid adenomlu hastaların sağlıklı bireylerden ayrılmasında spesifik ve hassas bir biyobelirteç olabileceğini göstermiştir. Sonuç: Sonuç olarak, primer hiperparatiroidizm hastalarında ölçülen düşük trombosit lenfosit oranı değerleri paratiroid adenomu tanısı için preoperatif yeni bir biyobelirteç olabilir.

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“…Recently, we demonstrated that serum PTH levels are positively associated with inflammatory markers (4). Furthermore, using the neutrophil-to-lymphocyte ratio as a surrogate marker of inflammation, parathyroidectomy is associated with a decrease in systemic inflammation (5). Of note is the fact that there is a positive association between inflammatory markers and left atrial enlargement among dialysis patients (6).…”

mentioning

confidence: 97%

Increasing Age Hinders the Decline in B-Type Natriuretic Peptide Following Parathyroidectomy in Dialysis Patients

Chu

Yang

Lee

et al. 2019

In Vivo

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Background/Aim: Parathyroidectomy has beneficial effects on all-cause and cardiovascular mortality in patients with uncontrolled hyperparathyroidism. B-Type natriuretic peptide (BNP) correlates with the severity of heart failure. We aimed to investigate whether parathyroidectomy modulates the BNP levels in dialysis patients. Patients and Methods: Patients who underwent surgical intervention for hyperparathyroidism were included. The serum BNP levels were determined before parathyroidectomy and during follow-up. Results: The preoperative and postoperative BNP levels were 499±561 and 453±442 pg/ml, respectively (p=0.82). The baseline BNP level was positively correlated with weakness and headache, but not biochemical parameters. In multivariate analysis, age (odds ratio=0.837) and preoperative symptom score (odds ratio=0.935) were independent predictors for the postoperative decline in BNP levels Conclusion: The serum BNP levels may increase or decrease after parathyroidectomy. Younger age and lower symptom burden are associated with decline in BNP levels.

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Parathyroidectomy decreases neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios

Cited by 16 publications

References 48 publications

Association between inflammatory markers and primary hyperparathyroidism

Association between inflammatory markers and primary hyperparathyroidism

Platelet to Lymphocyte Ratio as a Predictive Biomarker for Preoperative Diagnosis of Parathyroid Adenoma

Increasing Age Hinders the Decline in B-Type Natriuretic Peptide Following Parathyroidectomy in Dialysis Patients

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