Parathyroid transplants and unilateral renal delivery of parathyroid hormone in domestic fowl

Abstract

Exogenous parathyroid hormone (bovine 1-84 PTH) was infused unilaterally into the renal portal system or unilaterally into the renal arterial system of domestic fowl. Endogenous PTH was secreted unilaterally into the renal portal system by parathyroid tissue transplanted to the leg muscle. None of the experimental protocols caused significant unilateral phosphaturia, although unilaterally infused kidneys were shown to have received significantly more PTH than the contralateral kidneys. The transplanted parathyroid tissue was a major source of endogenous PTH, as was indicated by the development of significant hypocalcemia following surgical removal of the transplant. Unilateral PTH infusion did cause a significant unilateral increase in sodium excretion and significant bilateral phosphaturia. These results demonstrate that the phosphaturic and natriuretic responses to PTH can be dissociated in clearance experiments.

Kidney Function in Domestic Fowl with Chronic Occlusion of the Ureter and Caudal Renal Vein

“…The groups did not differ significantly for any of the remaining comparisons. Because PAH is avidly extracted from the peritubular blood and secreted into the urine by proximal tubule cells, unilateral renal portal infusion of PAH (urine samples 1 to 3 in the present study) can be used to test for the presence or absence of portal blood flow from the external iliac vein to the kidney on the infused side Kissell and Wideman, 1985). When blood from the leg vein enters the portal system on the infused side, the C PAH by the infused kidney exceeds C PAH by the uninfused kidney.…”