Parathyroid Insufficiency and the Human Electroencephalogram

Odoriz, J. B.; Castillo-Rodríguez, Esmeralda; Manfredi, J.F.; Balze, F. A. De La

doi:10.1210/jcem-4-10-493

Cited by 21 publications

(5 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diffuse slow-wave activity was the characteristic EEG finding at the initial evaluation of seizures and has been described earlier (4,5,17,18). The association of intracranial calcification with seizures has also been reported in our earlier study (13).…”

Section: Discussionsupporting

confidence: 84%

See 1 more Smart Citation

Seizures in patients with idiopathic hypoparathyroidism: effect of antiepileptic drug withdrawal on recurrence of seizures and serum calcium control

Modi¹,

Tripathi²,

Saha³

et al. 2014

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: There is limited information on seizures in patients with idiopathic hypoparathyroidism (IH). We assessed seizure characteristics at presentation, subclinical seizures during follow-up, and the effect of antiepileptic drug (AED) withdrawal in IH patients. Designs and methods: Seizure characteristics were assessed in 70 patients with IH attending endocrine clinic. Provoked electroencephalography (EEG) was performed for subclinical seizures in 44 of them. AEDs were withdrawn using strict criteria, i.e. i) no seizure during past 2 years, ii) normal EEG, iii) serum total calcium R1.8 mmol/l, and iv) feasibility to follow-up regularly after AED withdrawal for at least 9 months (nZ14). The effects of AED withdrawal on seizures and serum total calcium were assessed. Results: Seizures were present in 64.3% of patients, generalized tonic-clonic in 86.7%, and treated with phenytoin (46.7%), valproate (40%), and carbamazepine (26.7%). Most (69/70) patients were seizure-free during the follow-up of 6.6G4.5 years. Ten of 14 (71.4%) patients were successfully withdrawn from AED and remained seizure free during the follow-up period of 13.5G2.4 months (range 9-18). AEDs were restarted because of the recurrence of seizures (nZ3) and poor compliance with calcium/vitamin D (nZ1). The mean serum total calcium increased from 1.9G0.19 to 2.1G0.14 mmol/l after AED withdrawal (PZ0.004). Conclusion: Seizures were present in 64.3% of patients with IH and they responded to AED and calcium/1-a-(OH)D during the follow-up. With strict eligibility criteria, it was possible to withdraw AED in 71% of patients with IH. Serum total calcium improved significantly after AED withdrawal.

show abstract

Section: Discussionsupporting

confidence: 84%

“…Generalized tonic-clonic seizures (GTCS) are most common followed by petit mal, partial, atonic, and subclinical seizures assessed by electroencephalography (EEG) (1,2,3,4,5). Similar seizures are also observed in post-surgical IH with a normal range (NR).…”

Section: Introductionmentioning

confidence: 99%

Seizures in patients with idiopathic hypoparathyroidism: effect of antiepileptic drug withdrawal on recurrence of seizures and serum calcium control

Modi¹,

Tripathi²,

Saha³

et al. 2014

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…The abnormalities in the human electroencephalo gram in parathyroid insufficiency were corrected by parathyroid grafts (87). Parathyroidectomy in lactating rats (88) caused a decline but not cessation of lactation and no symptoms of tetany developed.…”

Section: The Parathyroid Glandsmentioning

confidence: 99%

Metabolic Functions of the Endocrine Glands

Lukens¹

1947

Annu. Rev. Physiol.

View full text Add to dashboard Cite

“…High levels of magne1lium, however, caused slowing of cortical waves. With low calcium levels encountered in parathyroid insufficiency, slow waves and scattered single spikes were seen and an exceedingly great sensitivity to hy perventilation developed (198). Thiamine deficiency has been found to cause electroencephalographic abnormality in pigeons (199) and chicks (200).…”

Section: Chemical Composition Of the Nerve Cell Environmentmentioning

confidence: 99%

Electrical Activity of the Brain

Gibbs¹

1945

Annu. Rev. Physiol.

View full text Add to dashboard Cite

Parathyroid Insufficiency and the Human Electroencephalogram

Cited by 21 publications

References 1 publication

Seizures in patients with idiopathic hypoparathyroidism: effect of antiepileptic drug withdrawal on recurrence of seizures and serum calcium control

Seizures in patients with idiopathic hypoparathyroidism: effect of antiepileptic drug withdrawal on recurrence of seizures and serum calcium control

Metabolic Functions of the Endocrine Glands

Electrical Activity of the Brain

Contact Info

Product

Resources

About