Parathyroid Hormone-related Peptide (hPTHrP) and Parathyroid Hormone-related Peptide Receptor Type 1 (PTHR1) Expression in Human Thymus

Gessi, Marco; Monego, Giovanni; Lauriola, Libero; Maggiano, Nicola; Ranelletti, Franco O.

doi:10.1369/jhc.4a6548.2005

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…As a previous research revealed that parathyroid hormone-like peptide (PTHrP) receptor is expressed in human thymus [16], so we initially suspected that the thymic mass might secret PTHrP which can result in hypercalcemia. But we could not test PTHrP as we found no commercial test for PTHrP in China.…”

Section: Discussionmentioning

confidence: 99%

The coexistence of hypercalcemia, osteoporosis and thymic enlargement in graves’ disease: a case report

Yan

2020

BMC Endocr Disord

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Background: Hyperthyroidism-induced hypercalcemia has been reported previously, but hypercalcemia accompanied by severe osteoporosis and significant thymic enlargement in patients with hyperthyroidism is quite rare. We report the coexistence of hypercalcemia, osteoporosis and thymic enlargement in a patient with Graves' disease. Case presentation: A 22-year-old female was diagnosed as Graves' disease with obviously elevated serum calcium and reduced parathyroid hormone levels. Dual-energy x-ray absorptiometry and chest enhanced computer tomography (CT) revealed severe osteoporosis and a significant enlargement of thymus. After the successful control of hyperthyroidism with methimazole, hypercalcemia was corrected, bone mineral density was improved and thymus also shrank obviously. Conclusion: This is a very rare case of hypercalcemia accompanied by severe osteoporosis and significant thymic enlargement induced by Graves' disease. In clinical practice, examination of thymus and bone density should be considered when a patient with Graves' disease was present with hypercalcemia.

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Section: Discussionmentioning

confidence: 99%

The coexistence of hypercalcemia, osteoporosis and thymic enlargement in graves’ disease: a case report

Yan

2020

BMC Endocr Disord

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“…Another lineage known to express PPR is dendritic cells (DCs). 123 However, DCs have not been implicated in the mechanism of action of PTH in bone.…”

Section: Skeletal Effects Of Pthmentioning

confidence: 99%

“…Although macrophages express the PTH receptor PPR, the available data suggest that BMMs play a permissive role in the anabolic activity of iPTH. Another lineage known to express PPR is dendritic cells (DCs) . However, DCs have not been implicated in the mechanism of action of PTH in bone.…”

Section: Skeletal Effects Of Pthmentioning

confidence: 99%

T cells, osteoblasts, and osteocytes: interacting lineages key for the bone anabolic and catabolic activities of parathyroid hormone

Pacifici

2015

Annals of the New York Academy of Sciences

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Osteoimmunology is field of research dedicated to the study of the interactions between the immune system and bone. Among the cells of the immune system that regulate bone turnover and the responsiveness of bone cells to calciothropic hormones are bone marrow T lymphocytes. T cells secrete osteoclastogenic cytokines such as RANKL and TNF-α, as well as factors that stimulate bone formation, one of which is Wnt10b. In addition, T cells regulate the differentiation and life span of stromal cells and their responsiveness to parathyroid hormone (PTH) via costimulatory molecules expressed on their surface. The conditioning effect of T cells on stromal cells (SCs) is inherited by the osteoblastic and osteocytic progeny of SCs. As a result, osteoblastic cells of T cell–deficient mice have functional characteristics different from corresponding cells of T cell–replete mice. These differences include the ratio of RANKL/OPG produced in response to continuous PTH treatment, and the osteoblastogenic response to intermittent PTH treatment. This article reviews the evidence indicating that the effects of parathyroid hormone are mediated not only by osteoblasts and osteocytes but also by T cells.

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Human parathyroid hormone-related protein and human parathyroid hormone receptor type 1 are expressed in human medulloblastomas and regulate cell proliferation and apoptosis in medulloblastoma-derived cell lines

Gessi

Monego²,

Calviello

et al. 2007

Acta Neuropathol

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Human parathyroid hormone-related protein (hPTHrP), identified in patients with paraneoplastic hypercalcemia and expressed by different cell types during development and adult life, plays important roles in many human neoplasms. Immunohistochemical and RT-PCR analyses of hPTHrP and human parathyroid hormone receptor type 1 (PTHR-1) in primary medulloblastoma confirmed their expression in both classic and desmoplastic variants at RNA and protein levels. To evaluate the functional role of hPTHrP, DAOY and D283 medulloblastoma and U87MG glioma cells, expressing high levels of hPTHrP and PTHR-1, were treated with anti-sense oligonucleotides for hPTHrP. Anti-sense treatment produced in all cell lines a decrease of cell proliferation and clonogenic activity and an increase of apoptosis, while addition of exogenous hPTHrP (1-37) prevented these effects. Anti-sense induced the increase of Caspase-3, Fas (CD95) mRNAs and Bax/Bcl-2 mRNA ratio after 12 h of cell treatment. Exogenous hPTHrP (1-37) increased intracellular Ca(2+) concentration in DAOY cells as revealed by FURA. Anti-sense treated cells showed a significant decrease of steady-state levels of intracellular Ca(2+), which was reverted by addition of exogenous hPTHrP (1-37). This study indicates that hPTHrP and PTHR-1 are expressed in medulloblastoma and could promote tumor growth, protecting cells from apoptosis.

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Parathyroid Hormone-related Peptide (hPTHrP) and Parathyroid Hormone-related Peptide Receptor Type 1 (PTHR1) Expression in Human Thymus

Cited by 5 publications

References 38 publications

The coexistence of hypercalcemia, osteoporosis and thymic enlargement in graves’ disease: a case report

The coexistence of hypercalcemia, osteoporosis and thymic enlargement in graves’ disease: a case report

T cells, osteoblasts, and osteocytes: interacting lineages key for the bone anabolic and catabolic activities of parathyroid hormone

Human parathyroid hormone-related protein and human parathyroid hormone receptor type 1 are expressed in human medulloblastomas and regulate cell proliferation and apoptosis in medulloblastoma-derived cell lines

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