1989
DOI: 10.1016/0006-291x(89)90851-6
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Parathyroid hormone (PTH) and PTH-like protein (PLP) stimulate interleukin-6 production by osteogenic cells: A possible role of interleukin-6 in osteoclastogenesis

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Cited by 362 publications
(149 citation statements)
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“…IL-6 mRNA expression in stromal cells reaches its peak by 1 hr and returns to the basal level by 2 hr after PTH administration. The similarity of the time course of PTHinduced IL-6 mRNA expression between previous in vitro studies with osteoblastic cells [4,11] and our in situ hybridization data are consistent with the notion that stromal cells that express IL-6 transcripts in response to PTH in vivo belong to the osteoblast lineage. Moreover, since IL-6 mRNA is not detected in mature osteoblasts at any of the time points (0 to 6 hr) examined after PTH injection, it is speculated that osteoblast precursors are the principal bone cells that manifest an IL-6 response to PTH in vivo, although we do not exclude the possibility that these IL-6 expressing cells belong to other cell lineage such as the osteoclast lineage.…”
supporting
confidence: 90%
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“…IL-6 mRNA expression in stromal cells reaches its peak by 1 hr and returns to the basal level by 2 hr after PTH administration. The similarity of the time course of PTHinduced IL-6 mRNA expression between previous in vitro studies with osteoblastic cells [4,11] and our in situ hybridization data are consistent with the notion that stromal cells that express IL-6 transcripts in response to PTH in vivo belong to the osteoblast lineage. Moreover, since IL-6 mRNA is not detected in mature osteoblasts at any of the time points (0 to 6 hr) examined after PTH injection, it is speculated that osteoblast precursors are the principal bone cells that manifest an IL-6 response to PTH in vivo, although we do not exclude the possibility that these IL-6 expressing cells belong to other cell lineage such as the osteoclast lineage.…”
supporting
confidence: 90%
“…The time course of PTHinduced IL-6 mRNA expression in vivo is similar to the previously reported in vitro data with clonal osteoblastic cell lines and primary osteoblasts [3,4,11], and exhibits a typical "immediate early gene response" pattern [16], i.e. transient and brief expression with its peak ranging from 1/4 to 1 hr.…”
supporting
confidence: 82%
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“…These findings agree with those of other in vivo and in vitro studies. 4,8,9,12,13,15,16,21,28-35. IL-1 and IL-6 modulate the function of many cell lines including monocytes, macrophages, fibroblasts, osteoblasts, osteoclasts, and T and B lymphocytes, 4,13,[36][37][38][39][40][41] as well as the effects of IL-2 and TNF␣; the latter cytokine is also proinflammatory. Thus, IL-1 and IL-6 have important roles in modulating immune functions and the growth, differ- entiation and remodelling of mesenchymal tissue.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, IL-1 and IL-6 are important in osteoclast-mediated bone resorption since they stimulate directly the differentiation and maturation of osteoclast precursors. [36][37][38][39][40][41] TGF␤ is generally an antiinflammatory, immune-suppressant cytokine, important in the repair and remodelling of mesenchymal tissue. 38 It also has a significant role in wound healing, facilitates the formation of the extracellular matrix by osteoblasts and other cells, and inhibits osteoclast function.…”
Section: Discussionmentioning
confidence: 99%