Parathyroid hormone-like peptide in normal and neoplastic mesothelial cells

Abstract

Mesothelioma has not been commonly reported as a cause of hypercalcemia of malignancy. We have studied a patient with malignant mesothelioma and hypercalcemia in association with elevated plasma concentrations of parathyroid hormone-like peptide (PLP). Immunohistochemical analysis of the tumor and seven of eight other mesotheliomas that were not associated with hypercalcemia revealed the presence of PLP cytoplasmic immunopositivity. PLP immunopositivity was also detected in normal and reactive mesothelial cells. The results of these studies suggest that PLP immunoreactivity is common in normal and neoplastic mesothelial cells and raises the possibility that PLP production may play a role in the pathogenesis of hypercalcemia associated with mesothelioma.

ActivatedPTHLHCoupling Feedback Phosphoinositide to G-Protein Receptor Signal-Induced Cell Adhesion Network in Human Hepatocellular Carcinoma by Systems-Theoretic Analysis

“…Study of PTHLH is presented in some papers, such as Mouse pthlh gene-specific expression profiles distinguish among functional allelic variants in transfected human cancer cells [2]; parathyroid hormone-like protein alternative messenger RNA splicing pathways in human cancer cell lines [3]; parathyroid hormone-like peptide in pancreatic endocrine carcinoma and adenocarcinoma associated with hypercalcemia [4]; parathyroid hormone and parathyroid hormone-like peptide bioactivity in situ biochemistry [5]; parathyroid hormone-like protein polypeptides immunological identification and distribution in normal and malignant tissues [6]; dysregulation of parathyroid hormone-like peptide expression and secretion in a keratinocyte model of tumor progression [7]; all major lung cancer cell types produce parathyroid hormone-like protein [8]; parathyroid hormone-like peptide in normal and neoplastic mesothelial cells [9]. Yet the high expression activated PTHLH feedback-mediated cell adhesion mechanism in HCC is not clear and remains to be elucidated.…”