Parathyroid hormone is inversely related to endothelin‐1 in patients on haemodialysis

Abstract

For the first time in vivo, we demonstrated an inverse independent relationship between endothelin-1 and parathyroid hormone in haemodialysed patients. Because both endothelin-1 and parathyroid hormone are endowed with well-known harmful actions on cardiovascular apparatus, whether such inverse relation may really influence the natural history of cardiovascular damage due to secondary hyperparathyroidism remains to be elucidated.

Cross-Talk Between Endothelin-1 and Mineral Metabolism in Hemodialysis Patients: a Cross-Sectional Study

“…In contrast, Palermo et al showed an inverse and independent relationship between the circulating levels of PTH and ET-1 in HD patients. The results of the present study seem to be against with results of Palermo et al (15) bivariate correlation analysis showed that PTH is directly correlated with ET-1. Such a correlation seems to be logic as high levels of both ET-1 and PTH are usually found in CKD patients, and both could participate in enhancing CV damage in this population.…”

Editorial: Beyond the expectation: A hopeful prospect of endothelin‐1 on parathyroid function

“…In this issue of Nephrology , Palermo et al. , for the first time, in literature, demonstrated an inverse independent relationship between ET‐1 and PTH in haemodialysis patients 10 . They proposed that ET‐1 and PTH might modify each other in the contribution of cardiovascular pathogenesis.…”