Parathyroid hormone in coronary artery disease — Results of a prospective study —

Herrmann, G.; Hehrmann, R.; Scholz, Holger; Atkinson, Michael J.; Lichtlen, Paul R.; Mühlen, A. von zur; Hesch, R. D.

doi:10.1007/bf03346923

Cited by 19 publications

(14 citation statements)

References 45 publications

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“…however, there are several reported mechanismsby which chest pain can develop, including increased deposition of calcium in the fibrous skeleton of the heart and valvular cusps as well as in coronary arteries (8,9), in addition to ac- hypertrophy, leading to increased oxygen demand and relative myocardial ischemia (12, 13). Similarly, the chest pain resolved in this patient after calcium levels and blood pressure had been normalized, indicating a possible relative myocardial ischemia.…”

Section: Discussionmentioning

confidence: 99%

Hypercalcemia Due to Vitamin D Intoxication with Clinical Features Mimicking Acute Myocardial Infarction

et al. 2003

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Wereport a case of hypercalcemia in an elderly patient due to vitamin D intoxication with clinical features and electrocardiogram (ECG) findings mimicking acute myocardial infarction. A 78-year-old man was referred to our department with symptoms of general fatigue, anorexia and chest pain. The ECGdemonstrated ST elevation in leads Vi to V3 and diffuse T wave flattening, resulting in myocardial infarction being suspected. However, his symptoms, including chest pain, gradually improved and the ECG returned to normal in accordance with a fall in his serum calcium level. Weintroduce the use of QaTc interval shortening in differentiating ST-T changes of hypercalcemia from those of true myocardial ischemia. (Internal Medicine 42: 340-344, 2003)

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Section: Discussionmentioning

confidence: 99%

Hypercalcemia Due to Vitamin D Intoxication with Clinical Features Mimicking Acute Myocardial Infarction

et al. 2003

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“…The methods and the results for the determination of calcium concentration in plasma, cortisol, prolactin, creatinine, and creati nine clearance as well as the measurement of cAMP in unextractcd plasma samples are reported in more details elsewhere [9].…”

Section: Determination O F Pth-dependent Calcium Transport and Camp Pmentioning

confidence: 99%

“…In a clinical study [9], we determined the plasma concentrations of the (44-68) PTH peptide in patients who underwent heart catheterization. This was performed to demonstrate or exclude coronary artery dis ease in patients with myocardial infarction, typical or atypical angina and valvular heart disease.…”

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confidence: 99%

Type II PTH Receptor-Operated Calcium Channel and Its Importance for PTH Peptide Elevations in Coronary Artery Disease

et al. 1986

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“…Post-surgical restoration of normocalcemia and normalization of parathyroid hormone valvular sclerosis persists without evidence of progression. Hypercalcemia may coincide with or induce hypertension (7)(8)(9)(10)(11), calcification of the coronary arteries (12,13) and valves (13)(14)(15)(16), hypercontractility of the heart muscle, left ventricular hypertrophy, and subsequently increased oxygen demand (16 -20), myocardial calcific deposits (16,(21)(22)(23)(24)(25)(26), and/or triggered arrhythmias (23,27,28). (J Clin Endocrinol Metab 82: 106 -112, 1997) T HE ROLE of hyperparathyroidism in heart disease is controversial.…”

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confidence: 99%

Cardiac Abnormalities in Patients with Primary Hyperparathyroidism: Implications for Follow-Up

Stefenelli¹,

Abela²,

Frank³

et al. 1997

The Journal of Clinical Endocrinology & Metabolism

164

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Patients with primary hyperparathyroidism (PHPT) show a high incidence of left ventricular hypertrophy, cardiac calcific deposits in the myocardium, and/or aortic and mitral valve calcification and thus may carry an increased risk of death from circulatory diseases. This prospective study was designed to assess an effect of parathyroidectomy on cardiac abnormalities of patients with PHPT. Echocardiography was used to evaluate the mechanical performance of the heart muscle, the thickness of the left ventricular wall, myocardial calcific deposits, and valvular calcifications within 12 and 41 months after parathyroidectomy. In a blinded fashion, aortic and mitral value calcifications were determined in 46% and 39% of patients with PHPT. Calcific deposits in the myocardium were found in 74% of patients. Follow-up studies after parathyroidectomy disclosed no evidence of progression of these calcifications. Before operation left ventricular hypertrophy was detected in 82%. After parathyroidectomy and 41 months of normocalcemia and normal PTH concentrations, a regression of hypertrophy of the interventricular septum and the posterior wall by -6% and -19% (P < 0.05) was observed. Subgroup analysis disclosed the most impressive long-term reduction of left ventricular hypertrophy in patients without a history of hypertension (-11% and -21%; P < 0.05 and P < 0.005); no changes were determined in 9 patients who developed secondary hyperparathyroidism after operation. The present data show a high incidence of left ventricular hypertrophy and aortic and/or mitral valve calcifications in patients with PHPT. Follow-up at 1 year and at 41 months after successful parathyroidectomy disclose regression of hypertrophy. Our results give evidence that parathyroid hormone per se plays an important role in the maintainance of myocardial hypertrophy. Post-surgical restoration of normocalcemia and normalization of parathyroid hormone valvular sclerosis persists without evidence of progression. We further conclude that patients with PHPT and parathyroidectomy are at low risk for the development of severe aortic and mitral valve stenosis within this period of time.

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Parathyroid hormone in coronary artery disease — Results of a prospective study —

Cited by 19 publications

References 45 publications

Hypercalcemia Due to Vitamin D Intoxication with Clinical Features Mimicking Acute Myocardial Infarction

Hypercalcemia Due to Vitamin D Intoxication with Clinical Features Mimicking Acute Myocardial Infarction

Type II PTH Receptor-Operated Calcium Channel and Its Importance for PTH Peptide Elevations in Coronary Artery Disease

Cardiac Abnormalities in Patients with Primary Hyperparathyroidism: Implications for Follow-Up

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