Parathyroid Cysts: Diagnosis and Management

Ihm, Peter; Dray, Todd G.; Sofferman, Robert A.; Nathan, Muriel H.; Hardin, Nicholas J.

doi:10.1097/00005537-200109000-00015

Cited by 40 publications

(44 citation statements)

References 8 publications

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“…Most studies agree that the presence of fluid, glossy, aqueous liquid is highly suggestive of parathyroid cyst, indicating verification of PTH dosage in the liquid to determine the diagnosis 5,7,12 . The analysis of intra-cyst liquid containing high levels of PTH portion C-terminal alone or combination of PTH portion N-terminal with high serum level is diagnosed as parathyroid cyst 5 .…”

Section: Discussionmentioning

confidence: 93%

“…Analyses in autopsies revealed 40 to 50% of parathyroid glands that contained asymptomatic microcysts 5 , given that in only 1 to 3% they presented as a neck mass 6 . Parathyroid cysts occur in both genders, with the proportion of 2.5:1 women to men, normally at the 4th and 5th decades of life 7 . The vast majority is located in lower parathyroid glands, described from the mandible angle to the mediastinum, with slight predominance on the left 5 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cisto de paratireóide: aspectos diagnósticos e tratamento

Silva

Machado

Brito

et al. 2004

Rev. Bras. Otorrinolaringol.

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Parat hyroid cysts are rare lesions, usually located in the neck and mediastinum in about 10% of the cases, predominantly in women. The majority of the lesions are nonfunctioning; however, functioning cysts are associated with hyperparathyroidism. The diagnosis of parathyroid cyst is difficult, and frequently misdiagnosed as thyroid pathology and the final diagnosis is made during surgery confirmed by histopathological examination. A crystal clear fluid and elevated PTH levels in cyst fluid confirm the diagnosis.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Cisto de paratireóide: aspectos diagnósticos e tratamento

Silva

Machado

Brito

et al. 2004

Rev. Bras. Otorrinolaringol.

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show abstract

“…Functioning PCs may hold a yellow or brown aspirate as a result of degeneration of a parathyroid adenoma containing hemosiderin. Diagnosis can be established by elevated PTH levels in the aspiration fluid [48]. PTH concentration in the cystic fluid of non-functioning PCs ranges from several hundred to over 400,000 pg/ml with normal serum PTH levels [49].…”

Section: Discussionmentioning

confidence: 99%

Cystic parathyroid glands in MEN1: A rare entity?

et al. 2016

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Approximately 300 cases of sporadic parathyroid cyst (PCs) have been reported to date. Only two cases have been described in MEN1 so far. Detection by imaging could be challenging, especially in multiglandular primary hyperparathyroidism (HPT) and clinical outcome could be different. During the period 1990-2014, 71 MEN1 patients were operated for primary hyperparathyroidism in our centre. We report three cases of PCs in MEN1 patients affected by HPT, who underwent a total or subtotal parathyroidectomy with transcervical thymectomy. In our series, all three patients had an unsatisfactory postoperative course, at variance with the high percentage (over 90 %) of long-term success in MEN1 patients operated at our centre. One patient affected by cystic degeneration of all the four parathyroid glands reported persistent hypoparathyroidism, despite autografts of parathyroid tissue. For the other two cases, surgery failed to cure hyperparathyroidism, perhaps because of the presence of undetected ectopic parathyroid tissue. In the context of a multiglandular disease such as MEN1 syndrome, PCs seem rare but our experience shows about a 4 % incidence. Furthermore their presence, even in expert hands, could affect the preoperative identification of the parathyroid glands due to the difficult differential diagnosis between PC and other cystic lesions of the neck, and intraoperative detection of the glands as well as the postoperative outcome.

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“…The typical findings of a watery, colorless crystal clear fluid are, in the majority of cases, suggestive of the diagnosis of a non-functional PC. The diagnosis may be established by elevated levels of PTH in the aspirated fluid (14).…”

Section: Case Reportmentioning

confidence: 99%

Giant non-functional parathyroid cyst: A case report

Zhang

Yuan

et al. 2016

Oncology Letters

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Abstract. Giant parathyroid cysts (PCs) are a rare entity and possess a benign clinical course. PCs may be functional or non-functional, depending on the ability of the cyst to secrete parathyroid hormone (PTH). The present study reports a rare case of a giant PC in a 56-year-old male who presented to the Affiliated Tumor Hospital, Zhengzhou University (Zhengzhou, Henan, China) with a 10-month history of exertional dyspnea, associated with mild dysphagia that had persisted for 3 months. The present study reviews the clinical situation, laboratory examination, radiographic findings, treatment and prognosis of the patient, and provides a brief discussion regarding the associated literature. Giant PCs may manifest with compressive symptoms of the surrounding tissues. The diagnosis of a giant PC is based on increased levels of PTH in the fluid collected during the aspiration of the cyst. Management by surgical excision is recommended for giant PCs that cause local cervical symptoms.

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Parathyroid Cysts: Diagnosis and Management

Cited by 40 publications

References 8 publications

Cisto de paratireóide: aspectos diagnósticos e tratamento

Cisto de paratireóide: aspectos diagnósticos e tratamento

Cystic parathyroid glands in MEN1: A rare entity?

Giant non-functional parathyroid cyst: A case report

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