Parathyroid carcinoma: A clinical study of seven cases of functioning and two cases of nonfunctioning parathyroid cancer

Aldinger, Keith A.; Hickey, Robert C.; Ibañez, Michael L.; Samaan, Naguib A.

doi:10.1002/1097-0142(19820115)49:2<388::aid-cncr2820490230>3.0.co;2-f

Cited by 100 publications

(67 citation statements)

References 32 publications

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“…Infact, she never had very high levels of hypercalcaemia suggesting the possibility of non functioning parathyroid carcinoma [10,11]. Nonproducing parathyroid carcinoma compares unfavourably with producing parathyroid carcinoma in terms of tumour progression and prognosis.…”

Section: Discussionmentioning

confidence: 97%

A complex case of Multiple Endocrine Neoplasia type 1 with Metastatic Parathyroid Carcinoma

2010

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AbstractWe describe below a patient with Multiple Endocrine Neoplasia type 1 (MEN type 1) who presented with features of Primary Hyperparathyroidism. However, the actual diagnosis of Parathyroid Carcinoma was delayed until metastases to the lung were discovered. She was also found to have Pituitary Macro adenoma with Silent Acromegaly, with no clinical features whatsoever. She underwent transphenoidal hypophysectomy with postoperative radiotherapy. However, the disease process remained biochemically active necessitating commencement of somatostatin analogues. There is also a tumour at the head of the pancreas which at present is non functional with normal gut hormone profile and normal 24 hour urinary 5-hydroxyl indole acetic acid (5-HIAA) excretion assay. Our case highlights the pitfalls in diagnosing the parathyroid carcinoma due to lack of initial proper histological features. The diagnosis of parathyroid carcinoma was based on histologically confirmed metastases to the lungs. We also discuss below the entity called Silent Acromegaly where patients have biochemically and/or histologically confirmed growth Hormone (GH) excess with no clinical features suggesting Acromegaly. We discuss the benefits of somatostatin analogues in indirectly controlling the rest of the tumours in MEN1 and hypothesise the same for metastatic parathyroid carcinoma. Metastatic parathyroid carcinoma with multiple endocrine neoplasia type 1 is extremely rare. Our case highlights the complexities of managing MEN1 with metastatic parathyroid carcinoma and the dilemmas in dealing with the various aspects of the care.

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Section: Discussionmentioning

confidence: 97%

A complex case of Multiple Endocrine Neoplasia type 1 with Metastatic Parathyroid Carcinoma

2010

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“…8 Although repeated surgical interventions have proven beneficial in palliative care, 9 excision of progressive tumor is not consistently curative. 10 In a recent review of 10 cases of parathyroid carcinoma treated at the Princess Margaret Hospital, 11 it was suggested that local RT to the tumor bed may decrease the strong predilection for local progression of the disease.…”

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confidence: 99%

Parathyroid carcinoma: Is there a role for adjuvant radiation therapy?

Munson

Foote

Northcutt

et al. 2003

Cancer

161

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BACKGROUNDThe authors proposed to determine risk factors associated with postoperative progression of parathyroid carcinoma within the neck (locoregional) and to assess the efficacy of postoperative adjuvant radiation therapy in preventing disease progression within the neck.METHODSA retrospective review of patients with pathologically confirmed parathyroid carcinoma who underwent surgical resection was performed. Risk factors identified on univariate analysis were applied in a proportional hazards analysis to identify significant independent predictors of locoregional disease progression and cause‐specific survival after surgical resection. Fifty‐seven patients were treated with surgery alone (no adjuvant radiation therapy [RT]) and were determined to have sufficient follow‐up and pathologically confirmed features to be included in the current analysis. Four patients were treated with surgery and adjuvant RT. Four patients received RT to the neck and mediastinum for unresectable locoregional disease progression. Patients were followed for a median of 75.6 months (range, 8.4–358 months).RESULTSTwenty‐five patients (44%) developed locoregional disease progression at a median of 27.1 months after surgery (range, 6.2–138.3 months). The univariate analysis revealed that surgical margin status and the institution at which the initial surgery was performed were predictive of locoregional progression‐free survival. The institution at which the initial surgery was performed was found to be an independent predictor of cause‐specific survival. Of the four patients treated with surgery and adjuvant RT, all were alive and without disease at the time of last follow‐up. All four patients who received RT for locoregional disease progression after initial surgery achieved locoregional disease control.CONCLUSIONSPatients with parathyroid carcinoma are reported to have a significant risk of locoregional disease progression after surgery alone. The results of the current study demonstrated that the risk of postoperative disease progression can be predicted by surgical margin status and the institution at which the initial surgery is performed. Patients treated with surgery and postoperative RT may have a lower risk of locoregional disease progression and improved cause‐specific survival. RT can be used to provide locoregional control of recurrent disease. Cancer 2003. © 2003 American Cancer Society.

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“…17 Death in patients with nonfunctional parathyroid tumors is primarily due to the volume of regional disease and metastases. 25 …”

Section: Discussionmentioning

confidence: 99%

Non-functional parathyroid carcinoma: a case report and review of the literature

Wang

Han

Chen

et al. 2015

Cancer Biology & Therapy

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Parathyroid carcinoma: A clinical study of seven cases of functioning and two cases of nonfunctioning parathyroid cancer

Cited by 100 publications

References 32 publications

A complex case of Multiple Endocrine Neoplasia type 1 with Metastatic Parathyroid Carcinoma

A complex case of Multiple Endocrine Neoplasia type 1 with Metastatic Parathyroid Carcinoma

Parathyroid carcinoma: Is there a role for adjuvant radiation therapy?

Non-functional parathyroid carcinoma: a case report and review of the literature

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