Parathyroid cancer: Outcome analysis of 16 patients treated at the princess margaret hospital

Erovic, Boban M.; Goldstein, David P.; Kim, Dae; Mete, Özgür; Brierley, James D.; Tsang, Richard W.; Freeman, Jeremy L.; Sylvia, L.; Rotstein, Lorne; Irish, Jonathan C.

doi:10.1002/hed.22908

Cited by 52 publications

(72 citation statements)

References 17 publications

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“…Parathyroid malignancy is usually associated with a high rate of local and distant recurrence, despite curative resection, and most of patients require re-operation [3,4,25,36]. Persistent hypercalcaemia and progressive increase in PTH levels are often the first signs of recurrence [1,18].…”

Section: The Natural Course Of Parathyroid Carcinomamentioning

confidence: 99%

“…The sensitivity is higher when positive staining of PGP9.5 (encoded by ubiquitin gene UCHL1), combined with loss of parafibromin, is found [18,19,46]. What is more, loss of retinoblastoma protein is an additional reliable factor for making the proper diagnosis [3,8,36]. Overexpression of galectin-3 is also present in PCs [8].…”

Section: Histopathological Examinationmentioning

confidence: 99%

“…Data suggested that about 5% of subjects with hyperparathyroid crisis suffered from parathyroid cancer [34]. Additionally, patients with PC had 30 to 60% incidence of severe hypercalcaemia [6,25,36]. Patients with PC also have a greater chance of persistent or recurrent hyperparathyroidism than subjects with adenomas or hyperplasia [11].…”

Section: Making the Diagnosis Of Parathyroid Carcinomamentioning

confidence: 99%

“…Nephrolithiasis or nephrocalcinosis (in 30-60% of cases), renal insufficiency, bone pain, pathological fractures, and radiological findings such as osteitis fibrosa cystica (in 40-70% of cases), "salt and pepper" skull, and diffuse spinal osteopenia, are more common in PC. Similarly, severe pancreatitis and peptic ulcer disease occur more often in subjects with malignant disease [36,50,51]. Some authors reported that a palpable mass in the neck might be a helpful predictive factor for parathyroid carcinoma, but it is present in 15 to 75% of cases [11,18,52].…”

Section: Prace Poglądowementioning

confidence: 99%

“…Some authors reported that a palpable mass in the neck might be a helpful predictive factor for parathyroid carcinoma, but it is present in 15 to 75% of cases [11,18,52]. Other important clinical features suggesting parathyroid malignancy include: known distant metastases, hoarseness and recurrent laryngeal paralysis, or palpable cervical swelling (in 30-50% of cases) [36,50,51].…”

Section: Prace Poglądowementioning

confidence: 99%

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Pierwotna nadczynność przytarczyc w przebiegu raka przytarczyc — wyzwanie diagnostyczne i terapeutyczne

Dabrowska

Tarach

Zwolak

2015

Endokrynologia Polska

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Parathyroid carcinoma (PC) is a rare endocrine malignancy and the cause of primary hyperparathyroidism. It is usually associated with a high rate of local and distant recurrence. Laboratory findings and clinical symptoms may be similar to those in parathyroid adenoma. The histological features of PC may also be non-specific and the affected gland is often indistinguishable from a benign lesion. The proper diagnosis is commonly made months to years later when the disease recurs or metastases are present. Therefore, parathyroid carcinoma still remains a diagnostic and management challenge for many physicians. However, there are some features that, in combination, may help in diagnosis. Surgery still remains the only curative treatment, even in metastatic disease. In advanced, non-operable subjects, managing hypercalcaemia and controlling a tumour are the main goals. Morbidity is caused by hypercalcaemia rather than metastases. A multidisciplinary approach with experienced endocrinologists, pathologists, radiologists, nuclear medicine doctors, oncologists, and surgeons is needed to optimize patient outcome. StreszczenieRak przytarczyc (PC) jest rzadkim nowotworem złośliwym układu wewnątrzwydzielniczego, a także rzadką przyczyną pierwotnej nadczynności przytarczyc. Zazwyczaj wiąże się z wysokim odsetkiem miejscowych i odległych przerzutów. Wyniki badań laboratoryjnych i objawy kliniczne mogą przypominać te spotykane w przebiegu gruczolaków przytarczyc. Równie niespecyficzny jest obraz histopatologiczny raka przytarczyc, co powoduje trudności w diagnostyce różnicowej ze zmianami łagodnymi, będącymi gruczolakami. Właściwe rozpoznanie często jest stawiane z kilkumiesięcznym lub kilkuletnim opóźnieniem, w oparciu o nawrót choroby lub pojawiające się przerzuty. Mając na uwadze ten fakt, rak przytarczyc ciągle pozostaje wyzwaniem diagnostycznym i terapeutycznym dla wielu specjalistów. Jakkolwiek, wyróżnia się jednak pewne objawy, których obecność może pomóc w postawieniu właściwej diagnozy. Leczenie chirurgiczne pozostaje nadal jedyną skuteczną opcją terapeutyczną, nawet w sytuacji pojawienia się zmian przerzutowych. W zaawansowanych, nieoperacyjnych przypadkach głównym celem leczenia pozostaje obniżanie stężenia wapnia we krwi i kontrola wielkości guza. Śmiertelność związana z rakiem przytarczyc wynika raczej z hiperkalcemii, niż obecności przerzutów. W celu poprawy wyników leczenia, niezbędne jest podejście wielodyscyplinarne oraz współdziałanie wielu doświadczonych specjalistów: endokrynologów, patologów, radiologów, medyków nuklearnych, onkologów i chirurgów.

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Section: The Natural Course Of Parathyroid Carcinomamentioning

confidence: 99%

Section: Histopathological Examinationmentioning

confidence: 99%

Section: Making the Diagnosis Of Parathyroid Carcinomamentioning

confidence: 99%

Section: Prace Poglądowementioning

confidence: 99%

Section: Prace Poglądowementioning

confidence: 99%

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Pierwotna nadczynność przytarczyc w przebiegu raka przytarczyc — wyzwanie diagnostyczne i terapeutyczne

Dabrowska

Tarach

Zwolak

2015

Endokrynologia Polska

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Diagnostic dilemma in a rare case of nonfunctional parathyroid carcinoma at a referral facility in Northern Tanzania

Mremi

Kayuza

Amsi

et al. 2023

Clinical Case Reports

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Key Clinical Message Rare cancer originating from parathyroid parenchymal cells. Preoperative diagnosis is often difficult. Presents with normal serum levels of calcium and parathyroid hormone. Treated by en bloc resection. Benefits of adjuvant therapy are unclear. Abstract Parathyroid carcinoma is an uncommon endocrine tumor. Its typical presentation is that of primary hyperparathyroidism with elevated serum calcium and parathormone levels. Nonfunctioning carcinoma of the parathyroid gland with normal serum calcium levels is extremely rare. This paper describes a case of nonfunctioning parathyroid carcinoma and brief literature review thereof.

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Algorithmic approach to neuroendocrine tumors in targeted biopsies: Practical applications of immunohistochemical markers

Duan

Mete

2016

Cancer Cytopathology

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Neuroendocrine tumors (NETs) constitute a heterogeneous group of neoplasms with distinct biological behaviors, depending on the site of origin and the degree of tumor proliferation. Although advances in biochemical and radiological modalities have enhanced the ability to detect NETs, tissue diagnosis remains the gold standard to assess tumor characteristics for treatment decision making. In an era with growing demands for precision diagnostics based on smaller tissue samples, immunohistochemistry has become an indispensable tool in the pathologist's repertoire. In conjunction with clinical findings and cytomorphology, complementary use of 1) markers of neuroendocrine differentiation, 2) markers confirming epithelial nature, 3) markers of cellular proliferation, 4) transcription factors and hormonal markers, as well as 5) predictive and prognostic markers may be necessary to guide patient management in NETs. The current review summarizes common applications of these immunohistochemical markers when confronted with a potential neuroendocrine neoplasm, and proposes a stepwise algorithmic approach to avoid diagnostic errors in targeted biopsies. Cancer Cytopathol 2016;124:871-84. V C 2016 American Cancer Society.

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Parathyroid cancer: Outcome analysis of 16 patients treated at the princess margaret hospital

Cited by 52 publications

References 17 publications

Pierwotna nadczynność przytarczyc w przebiegu raka przytarczyc — wyzwanie diagnostyczne i terapeutyczne

Pierwotna nadczynność przytarczyc w przebiegu raka przytarczyc — wyzwanie diagnostyczne i terapeutyczne

Diagnostic dilemma in a rare case of nonfunctional parathyroid carcinoma at a referral facility in Northern Tanzania

Algorithmic approach to neuroendocrine tumors in targeted biopsies: Practical applications of immunohistochemical markers

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