Paratesticular Pleomorphic Rhabdomyosarcoma: A Report of Two Cases

Abstract

Pleomorphic rhabdomyosarcoma (RMS) is a rare tumor with an aggressive behavior, described mainly in adulthood. Herein we present two cases of paratesticular pleomorphic RMS in 71- and 16-year-old patients with metastases at initial diagnosis. Histological, immunohistochemical, and ultrastructural findings were essential to confirm diagnosis. Few months after radical orchiectomy, both patients died before or just after starting adjuvant chemotherapy.

Paratesticular Embryonal Rhabdomyosarcoma with Lung Metastasis – A Rare Case Report

“…(2) (5) However, painful lesions are seen in only 7% of cases. (6) Large tumors can be mistaken for tumors of testicular origin as in our case. Spread of tumor can occur via lymphatics preferentially to retroperitoneal lymph nodes and by hematogenous spread to lung , bone and bone marrow.…”

“…(5) The other common sarcomas in the paratesticular region are leiomyosarcoma (32%), liposarcoma (20%), and malignant fibrous histiocytoma (13%). (6) There are two peaks of incidence, with the first peak more commonly in 1-5 years followed by a second peak in adolescence. (2)(5) (7) The tumor presents as a painless hard mass in the inguinoscrotal region which rarely invades the scrotal skin.…”

Pleomorphic rhabdomyosarcoma metastasis to small intestine causing intussusception

“…Pleomorphic rhabdomyosarcoma (PRMS) is a rare but highly malignant soft tissue cancer, accounting for 3% of soft tissue sarcomas which make up less than 1% of all adult malignancies. [4] Arising from striated muscle cells, PRMS is mostly located in the large muscles of the extremities, particularly the lower limbs and the trunk, such as the abdomen/retroperitoneum, chest, and abdominal wall, [3] although its occurrence around the head and neck area [5] and parenchymal organs, including the testis, [6] uterus, [7] and bladder, [8] has also been reported. In this study, we report a case of PRMS originated from the right shoulder but metastasized to the intestine, which is the first case reported to the best of our knowledge.…”

“…Metastasis of PRMS is commonly seen in the lungs, lymph nodes, and bone marrow. [6] This study reports a unique case of metastasis to the intestine, highlighting the importance of gastrointestinal examination by positron emission tomography (PET)-CT or endoscopy in future practice for patients with PRMS.…”

Sonographic Features and Diagnostic Algorithm of Common Scrotal Masses in Children: with Pathological Correlations

“…As metastasis of paratesticular tumours in retroperitoneal nodes is common, and up to 30% of patients present with lung metastases at the time of diagnosis, computed tomography of the thorax, abdomen, and pelvis is recommended for tumour staging. 17,18 MRI of the paratesticular solid mass can be performed to delineate the borders of the mass relative to the epididymis and testis. 3 Rhabdomyosarcoma is an important mimic of epididymitis which often results in delayed clinical detection.…”