Paratesticular leiomyosarcoma: A clinical case report

Kolev, Nikola; Karaivanov, M; Dimitrov, P.

doi:10.1016/j.eucr.2019.100913

Cited by 4 publications

(7 citation statements)

References 5 publications

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“…Chemotherapy is controversial and has only been used in the case of metastatic disease [ 1 , 4 ]. Although there is limited data about this tumor, some literature mentioned that five- and 10-year disease-specific survival rates are 77% and 66% respectively [ 10 ]. Regardless of this relatively good long-term survival, because recurrences are common, close follow-up is suggested for disease surveillance.…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Paratesticular Leiomyosarcoma

Peña¹,

Fernandez²,

Miller³

et al. 2023

Cureus

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Paratesticular leiomyosarcoma is a rare urologic cancer that arises from undifferentiated smooth muscles of the spermatic cord or epididymis. Few accounts of this cancer have been reported but previous reports have identified radiation and anabolic steroids as possible risk factors. We report a case of an 83-year-old man with a previous history of radiation therapy for prostate cancer, who presented with a painless left scrotal mass. Given the nonspecific presentation, a histopathological classification was warranted for a definitive diagnosis. The tumor was resected via simple orchiectomy and was diagnosed as a paratesticular grade III leiomyosarcoma without any further treatment. Patient had a follow-up CT scan of the abdomen and pelvis that was normal without metastasis. The patient’s history of previous external beam radiation and now development of a secondary tumor sums to the few cases that have been previously reported with this association.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of Paratesticular Leiomyosarcoma

Peña¹,

Fernandez²,

Miller³

et al. 2023

Cureus

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“…It has a mesenchymal cell origin and smooth muscle differentiation. There is no evidence for a genetic abnormality in spermatic cord LMS [ 8 ]. The disease-specific survival rate is between 77% [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…There is no evidence for a genetic abnormality in spermatic cord LMS [ 8 ]. The disease-specific survival rate is between 77% [ 8 ]. LMS of the spermatic cord is very rare with 113 cases reported to date worldwide [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

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Leiomyosarcoma of the spermatic cord: a rare paratesticular neoplasm case report

et al. 2022

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Background Primary soft tissue sarcomas contribute to only 2% of all malignancies arising from the male genitourinary tract. Leiomyosarcoma (LMS) is a malignant soft tissue neoplasm which originates from the mesenchyme and has a characteristic smooth muscle differentiation. Usually, it presents as a painless, firm, slow-growing unilateral scrotal mass. Investigations include imaging, tumor markers, and histopathology. Case presentation A 65-year-old gentleman known diabetic and beta-thalassemic trait was referred to the Urology OPD at Letterkenny University Hospital. His presenting complaint was a left groin lump that appeared 1 year ago and was growing larger in size gradually. According to the patient, his lump was slightly painful (localized) initially that later became painless. He did not report any testicular trauma/infection or UTI. There was no significant history of malignancies running through his family. Clinical examination revealed a soft and lax abdomen, normal testes. There was a non-tender 2cm x 2cm well-circumscribed, mobile, firm to cystic irreducible left inguinoscrotal mass and appeared to be attached to the spermatic cord. Cough impulse was indiscernible. Ultrasound left groin showed 1.8 cm transverse x 1.4 cm AP x 1.9 cm sagittal) well-circumscribed ovoid nodular subcutaneous lesion present in the upper left inguinal area just lateral to the left pubic tubercle that appeared solid with heterogeneous internal echotexture and no internal calcification. Some internal vascularity is demonstrated with color Doppler assessment. Conclusion Because of its rareness, LMS represents a management conundrum. There is no standard protocol for treatment. We present a case and discuss the available evidence from the literature to date to help identify LMS of the spermatic cord that is highly unusual.

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“…Rodriguez D et alreported that tumor grade, stage, histological type, lymph node metastasis, and distant metastasis were independent prognostic indicators of paratesticular leiomyosarcoma (4). Kolev et alproposed that EL recurrence is common; therefore, early diagnosis and differential diagnosis are very important (5).…”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic manifestations and the effective diagnosis of epididymal leiomyosarcoma: Case report and systematic literature review

Song

Xi²,

Shi³

et al. 2023

Front. Oncol.

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BackgroundEpididymal leiomyosarcoma is an extremely rare tumor. In this study, we describe the sonographic features of this uncommon tumor.MethodsA case of epididymal leiomyosarcoma diagnosed at our institute was retrospectively analyzed. Ultrasonic images, noted clinical manifestations, treatment procedures, and pathology results were collected for this patient. The same information was collected from a systematic literature search on epididymal leiomyosarcoma, including the PUBMED, Web of Science and Google Scholar databases.ResultsThe literature search resulted in 12 articles; we were able to extract data from 13 cases of epididymal leiomyosarcomatosis. The median patient age was 66 (35–78) years, and the average tumor diameter was 2–7 cm. All patients had unilateral epididymal involvement. The lesions were all solid, irregular-shaped in almost half of the cases, featured clear borders in six cases, and had unclear borders in four cases. The internal echogenicity was heterogeneous in the majority of lesions: six cases were hypoechoic (7/11) and three cases moderately echoic (3/10). Information on blood flow within the mass was provided in four cases, but all were noted with significant vascularity. Surrounding tissue invasion was discussed in 11 cases, with 4 featuring peripheral invasion or metastasis.ConclusionEpididymal Leiomyosarcoma demonstrates sonographic characteristics common to many malignant tumors, such as increased density, irregular shape, heterogeneous internal echogenicity, and hypervascular. Ultrasonography is helpful to differentiate benign epididymal lesions, and can provide some reference for clinical diagnosis and treatment. However, compared with other malignant tumors of the epididymis, it has no characteristic sonographic features,and pathological confirmation is required.

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Paratesticular leiomyosarcoma: A clinical case report

Cited by 4 publications

References 5 publications

A Rare Case of Paratesticular Leiomyosarcoma

A Rare Case of Paratesticular Leiomyosarcoma

Leiomyosarcoma of the spermatic cord: a rare paratesticular neoplasm case report

Ultrasonographic manifestations and the effective diagnosis of epididymal leiomyosarcoma: Case report and systematic literature review

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