Parasympathetic Nervous Activity Associated with Discoordination Between Physical Acceleration and Heart Rate Variability in Patients with Sleep Apnea

Taniguchi, Koichi; Shimouchi, Akito; Jinno, Naoya; Okumura, Naoko; Seiyama, Akitoshi

doi:10.1007/978-3-030-48238-1_36

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…Although sleep is normally a time when parasympathetic modulation of the heart predominates and myocardial electrical stability is enhanced, OSA and CSA disturb this quiescence, creating an autonomic profile in which both profound vagal activity, leading to bradyarrhythmias, and symptho-excitation favouring ventricular ectopy are observed. The resulting tendency toward cardiac arrhythmia may directly contribute to sudden cardiac death and premature mortality in patients with sleep apnea [ 23 , 24 ]. Thus, since both a decrease or an increase in beating rate is observed in OSA patients, either variation from the norm, including during apneic episodes can be of significance and important in promoting arrythmias.…”

Section: Discussionmentioning

confidence: 99%

Obstructive Sleep Apnea Syndrome In Vitro Model: Controlled Intermittent Hypoxia Stimulation of Human Stem Cells-Derived Cardiomyocytes

Regev

Etzion

Haddad

et al. 2022

IJMS

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Cardiovascular morbidity is the leading cause of death of obstructive sleep apnea (OSA) syndrome patients. Nocturnal airway obstruction is associated with intermittent hypoxia (IH). In our previous work with cell lines, incubation with sera from OSA patients induced changes in cell morphology, NF-κB activation and decreased viability. A decrease in beating rate, contraction amplitude and a reduction in intracellular calcium signaling was also observed in human cardiomyocytes differentiated from human embryonic stem cells (hESC-CMs). We expanded these observations using a new controlled IH in vitro system on beating hESC-CMs. The Oxy-Cycler system was programed to generate IH cycles. Following IH, we detected the activation of Hif-1α as an indicator of hypoxia and nuclear NF-κB p65 and p50 subunits, representing pro-inflammatory activity. We also detected the secretion of inflammatory cytokines, such as MIF, PAI-1, MCP-1 and CXCL1, and demonstrated a decrease in beating rate of hESC-CMs following IH. IH induces the co-activation of inflammatory features together with cardiomyocyte alterations which are consistent with myocardial damage in OSA. This study provides an innovative approach for in vitro studies of OSA cardiovascular morbidity and supports the search for new pharmacological agents and molecular targets to improve diagnosis and treatment of patients.

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Section: Discussionmentioning

confidence: 99%

Obstructive Sleep Apnea Syndrome In Vitro Model: Controlled Intermittent Hypoxia Stimulation of Human Stem Cells-Derived Cardiomyocytes

Regev

Etzion

Haddad

et al. 2022

IJMS

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“…After the completion of the 24-h monitoring, they returned to the laboratory. The experimental protocols have been described in detail previously (Taniguchi et al, 2015(Taniguchi et al, , 2021.…”

Section: Protocolsmentioning

confidence: 99%

Coordination between heart rate variability and physical activity may be diminished by fatigability in non‐older women in the hour before sleep

Taniguchi

Shimouchi

Jinno

et al. 2021

Physiological Reports

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“…After the 24‐h monitoring period, participants returned to the laboratory. The experimental protocols have been described in detail in our previous studies 21–23 …”

Section: Methodsmentioning

confidence: 99%

Depression is associated with discoordination between heart rate variability and physical acceleration in older women

Taniguchi,

Jinno,

Seiyama

et al. 2024

Health Science Reports

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Background and AimsIt is well known that depression is closely associated with the autonomic nervous system and physical acceleration (PA), which may cause functional time‐deviance between these two parameters. Exploring this relationship is important in sustaining the mental and physical health of older adults in daily life. However, few studies have assessed the relationship between depression and the coordination of parasympathetic nervous activity (PSNA) and PA. The present study was designed to investigate whether the coordination between PSNA and PA is associated with the mental state of healthy volunteers in normal daily lives and the underlying mechanism.MethodsIn total, 95 adult women were divided into non‐older and older groups comprising 50 (aged 20–59 years) and 45 (aged 60–85 years) women, respectively. PSNA and PA data were simultaneously obtained every minute for 24 h during the free‐moving day using the ActiveTracer accelerometer. Lag time was determined as the time difference between PSNA and PA, and it was introduced as a parameter of %lag0, which is the percent ratio of the lag = 0 min between PSNA and PA in 1 h. The General Health Questionnaire 28 (GHQ28) was used to evaluate the effects of psychological distress, including depression.ResultsIn the hour before sleep, %lag0 was significantly lower in older women (38.7 ± 6.4) who had higher GHQ28 values (subscale D = 0, n = 12) compared with that in older women (19.4 ± 10.5) with lower values (subscale D ≧ 1, n = 33) (p < 0.05).ConclusionImpairments in coordination between PSNA and PA are significantly associated with depression in older women, particularly in the hour before sleep on free‐moving days.

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Parasympathetic Nervous Activity Associated with Discoordination Between Physical Acceleration and Heart Rate Variability in Patients with Sleep Apnea

Cited by 3 publications

References 16 publications

Obstructive Sleep Apnea Syndrome In Vitro Model: Controlled Intermittent Hypoxia Stimulation of Human Stem Cells-Derived Cardiomyocytes

Obstructive Sleep Apnea Syndrome In Vitro Model: Controlled Intermittent Hypoxia Stimulation of Human Stem Cells-Derived Cardiomyocytes

Coordination between heart rate variability and physical activity may be diminished by fatigability in non‐older women in the hour before sleep

Depression is associated with discoordination between heart rate variability and physical acceleration in older women

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