Paraspinal and intraspinal calcinosis: frequent complications in patients with systemic sclerosis

Ogawa, Takehiko; Ogura, Takeshi; Ogawa, Kazufumi; Hirata, A.; Hayashi, Norihide; Izumi, Yoshinobu; Saito, Eizo

doi:10.1136/ard.2008.104216

Cited by 21 publications

(15 citation statements)

References 6 publications

(7 reference statements)

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“…It is generally recognized that calcinosis in SSc occurs in the late stage. It has been reported that the appearance of spinal calcinosis was more common in patients with long‐term disease duration (mean, 9.09 years) . In our study, among the SSc patients with spinal calcinosis, the frequency of spinal calcinosis in the SSc patients in the late stage (disease duration, >10 years) was higher than in the SSc patients in the early stage (disease duration, ≤5 years).…”

Section: Discussioncontrasting

confidence: 43%

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Demographic and clinical characteristics of spinal calcinosis in systemic sclerosis: Possible association with peripheral angiopathy

Motegi

Sekiguchi

Yonemoto

et al. 2018

The Journal of Dermatology

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The objective was to evaluate the demographic and clinical characteristics of systemic sclerosis (SSc) patients with spinal calcinosis. Paraspinal and intraspinal calcinosis was assessed blindly by orthopedic surgeons specializing in spinal diseases using chest high‐resolution computed tomography (CT) that was performed for the screening and prospecting of interstitial lung disease in 159 Japanese SSc patients. Among these patients, we identified 27 (17%) with spinal calcinosis, and the most common site was cervical level at 77.8% (21/27). The frequency of spinal calcinosis in the late stage was higher than in the early stage (44.4% vs 29.6%). Multiple calcinosis was identified in 18.5% (5/27). The frequency of paraspinal calcinosis only was 59.3%, intraspinal calcinosis only 18.5%, and both intraspinal and paraspinal calcinosis 22.2%. Among SSc patients, 4.4% (7/159) had CT‐based evidence of spinal cord compression. Among cases with spinal cord compression, only one had neurological symptoms, and surgical removal improved the symptoms. The other six SSc patients with spinal calcinosis (3.8% of 159) had no symptoms. Male sex (29.6%) and severe peripheral vasculopathy such as digital ulcers (55.6%) and acro‐osteolysis (33.3%) were significantly more frequent in the SSc patients with spinal calcinosis than in the SSc patients without spinal calcinosis (10.6%, 32.6% and 14.4%, respectively). Our results suggest that severe peripheral vasculopathy may be associated with the development of spinal calcinosis. Because SSc patients are prone to spinal calcinosis, when SSc patients claim symptoms such as pain, numbness and movement disorder of the extremities, spinal calcinosis is a complication that should be taken into consideration.

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Section: Discussioncontrasting

confidence: 43%

“…However, the pathogenesis of spinal calcinosis in SSc is not well‐known. Ogawa et al . reported that Raynaud's phenomenon and digital ulcers were significantly prevalent in SSc patients with spinal calcinosis.…”

Section: Discussionmentioning

confidence: 99%

Demographic and clinical characteristics of spinal calcinosis in systemic sclerosis: Possible association with peripheral angiopathy

Motegi

Sekiguchi

Yonemoto

et al. 2018

The Journal of Dermatology

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“…However, spinal and paraspinal calcifications, which cause serious neurologic complications, have been described in patients with SSc [12][13][14][15]. Furthermore, calcium hydroxyapatite deposition within the transverse ligament in SSc has been described in the literature [2].…”

Section: Discussionmentioning

confidence: 98%

Severe headache complicated by vertical atlantoaxial subluxation in diffuse systemic sclerosis with crowned dens pattern calcification

et al. 2010

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We report a 34-year-old female case of diffuse systemic sclerosis (SSc) with generalized ectopic calcification, who developed severe headache with vertical atlantoaxial subluxation (AAS) complicated by calcification around the odontoid process (crowned dens pattern calcification). Although a rare complication, AAS should be considered as a differential diagnosis of severe headache in SSc patients with extensive calcification.

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“…Although subcutaneous and soft tissue calcinosis are common in SSc, spinal calcinosis is not well recognized. [1][2][3][4][5] It is suggested that tissue hypoxia due to vasculopathy may be associated with the pathogenesis of calcinosis in SSc, but not well elucidated. Reports of intraspinal calcinosis in patients with SSc are still limited.…”

mentioning

confidence: 99%

“…[3][4][5] Sambataro et al 4 summarized 35 previously described cases of tumoral calcinosis in paravertebral areas in SSc patients, and determined that tumoral calcinosis of the spine is more frequent in dcSSc than in localized SSc, and that 54.3% of SSc patients with calcinosis of the spine (19/35) suffered from neurological symptoms due to spinal cord compression, such as pain, numbness, weakness and paralysis of extremities. Ogawa et al 5 reported that paraspinal calcinosis located in the thoracic spine was found in 24 out of 41 SSc patients (58.5%), of whom 12 patients (29.3%) showed intraspinal calcinosis simultaneously. In addition, they reported that Raynaud's phenomenon, digital ulcers and calcinosis cutis were significantly prevalent in SSc patients with spinal calcinosis.…”

mentioning

confidence: 99%

Progressive myelopathy in systemic sclerosis patient with cervical intraspinal calcinosis

Motegi

Sekiguchi

Toki

et al. 2016

The Journal of Dermatology

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Paraspinal and intraspinal calcinosis: frequent complications in patients with systemic sclerosis

Cited by 21 publications

References 6 publications

Demographic and clinical characteristics of spinal calcinosis in systemic sclerosis: Possible association with peripheral angiopathy

Demographic and clinical characteristics of spinal calcinosis in systemic sclerosis: Possible association with peripheral angiopathy

Severe headache complicated by vertical atlantoaxial subluxation in diffuse systemic sclerosis with crowned dens pattern calcification

Progressive myelopathy in systemic sclerosis patient with cervical intraspinal calcinosis

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