Parasitological and molecular search for Leishmania natural infection in phlebotomine sand flies in peri-urban and rural sites of an Argentinean area endemic for tegumentary leishmaniasis

Almazán, María Cristina; Copa, Griselda Noemí; Gil, José Fernando; Quiroga, Inés López; Fernández, Melisa Evangelina Díaz; Uncos, Alejandro; Hoyos, Carlos Lorenzo; Nasser, Julio R.; Barroso, Paola Andrea; Marco, Jorge Diego

doi:10.1016/j.actatropica.2021.106064

Cited by 1 publication

(1 citation statement)

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“…American Tegumentary Leishmaniasis (ATL) is an infectious disease transmitted to humans by the bite of infected phlebotomine sand flies, commonly known as "sand flies." (Martins et al, 2018;Almazán et al,2021) This zoonosis, caused by the protozoan of the genus Leishmania, presents different clinical forms, varying according to the species. In Brazil, ATL is a significant public health challenge, with several Leishmania species involved in the cases, with L. amazonensis, L. guyanensis, and L. braziliensis being the most important ones.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of intralesional treatment in american tegumentary leishmaniasis in the amazon region: results and perspectives

Farias,

Santos,

Oliveira

et al. 2024

Cuad. Ed. Desar.

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American Tegumentary Leishmaniasis (ATL) is an infectious disease transmitted to humans by the bite of infected phlebotomine sand flies, commonly known as "sand flies." In Brazil, ATL is a significant public health challenge, with a higher prevalence in the northern region, a predominance of males aged 20 to 40 years, and a higher incidence among the mixed-race population. Methodology: The study was conducted under the Education through Work for Health Program (PET-Saúde) in Santarém, Pará, between August and December 2022. Results: The predominant profile of ATL patients was adult male rural workers with cutaneous lesions mainly on the lower limbs. The most common clinical form was localized cutaneous lesion, representing over 90% of cases. Intralesional treatment with meglumine antimoniate was well-tolerated by patients, with few local side effects and a successful therapeutic response in most cases. Discussion: The results corroborated with the literature, showing the endemic profile of ATL in the Amazon region. Intralesional treatment proved to be effective and well-tolerated, being a relevant option for areas with limited resources and difficulties in accessing healthcare. Conclusion: The study provides evidence that intralesional treatment with meglumine antimoniate is an effective therapeutic option. Its high adherence suggests its consideration in public health policies for disease treatment. It is recommended that future studies expand the sample size and follow-up period to obtain more comprehensive information about this therapeutic approach.

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Section: Introductionmentioning

confidence: 99%