Parasitic disorders

Newton, Charles R.; Preux, Pierre‐Marie; Singhi, Prathiba

doi:10.1016/b978-0-444-52910-7.00034-9

Cited by 8 publications

(7 citation statements)

References 52 publications

(40 reference statements)

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“…NCC, an infection caused by the encysted larval stage of the tapeworm T. solium, constitutes one of the most common parasitic diseases of the nervous system in humans and is a major public health problem for most of the developing world 10,11 . The clinical manifestations of NCC are variable and strongly depend on the number, type, size, location, and stage of development of the cysticerci, as well as the immune response of the host against the parasite 12,13,14,15,16 .…”

Section: Discussionmentioning

confidence: 99%

Longer epilepsy duration and multiple lobe involvement predict worse seizure outcomes for patients with refractory temporal lobe epilepsy associated with neurocysticercosis

Meguins

Adry

Júnior

et al. 2015

Arq. Neuro-Psiquiatr.

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Objective To investigate the surgical outcomes of temporal lobe epilepsy associated with hippocampal sclerosis (TLE-HS) and neurocysticercosis (NCC). Methods A retrospective investigation of patients with TLE-HS was conducted in a tertiary center. Results Seventy-nine (62.2%), 37 (29.1%), 6 (4.7%), and 5 (3.9%) patients were Engel class I, II, III, and IV, respectively. Fifty-two (71.2%) patients with epilepsy durations ≤ 10 years prior to surgery were seizure-free 1 year after the operation compared to 27 (50.0%) patients with epilepsy durations > 10 years (p = 0.0121). Forty-three (72.9%) patients with three or fewer lobes affected by NCC were seizure-free one year after the operation, and 36 (52.9%) patients with more than three involved lobes were seizure-free after surgery (p = 0.0163). Conclusions Longer epilepsy durations and multiple lobe involvement predicted worse seizure outcomes in TLE-HS plus NCC patients.

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Section: Discussionmentioning

confidence: 99%

Longer epilepsy duration and multiple lobe involvement predict worse seizure outcomes for patients with refractory temporal lobe epilepsy associated with neurocysticercosis

Meguins

Adry

Júnior

et al. 2015

Arq. Neuro-Psiquiatr.

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“…The infection may be primary or secondary to the spontaneous or traumatic rupture of a primary cerebral cyst or because of embolization of cardiac cysts [ 22 ]. Cysts may remain asymptomatic until they are large enough to cause a mass effect.…”

Section: Clinical Manifestations Of the Main Parasitic Diseases Of Thmentioning

confidence: 99%

“…The CSF findings are variable from normal, a mild pleocytosis, to markedly raised protein. Identification of the S chistosoma is not common and occurs in only about one-quarter of the patients with myelopathy [ 22 ].…”

Section: Clinical Manifestations Of the Main Parasitic Diseases Of Thmentioning

confidence: 99%

“…The pathophysiology of brain involvement is multifactorial but is related to the degree of parasitemia, sequestration of schizonts in the brain venules, and the resulting vascular and perivascular damage [ 22 ]. Suggested mechanisms of injury include anoxia, vascular leakage, parasite toxin, metabolic derangements, increased intracranial hypertension, including stroke and others [ 5 ].…”

Section: Clinical Manifestations Of the Main Parasitic Diseases Of Thmentioning

confidence: 99%

“…Neuroimaging findings in schistosomiasis are variable and nonspecific. On CT, single or multiple variably enhancing hyperattenuated lesions with surrounding hypoattenuated edema may be present and reflect a focal granulomatous reaction [ 22 ]. MRI shows foci of low signal on T1 and high signal on T2, with contrast enhancement.…”

Section: Neuroimaging Diagnosis Of Parasitic Infections Of the Cnsmentioning

confidence: 99%

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Parasitic diseases of the central nervous system: lessons for clinicians and policy makers

Carpio

Romo

Parkhouse

et al. 2016

Expert Review of Neurotherapeutics

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Parasitic diseases of the central nervous system are associated with high mortality and morbidity, especially in resource-limited settings. The burden of these diseases is amplified as survivors are often left with neurologic sequelae affecting mobility, sensory organs, and cognitive functions, as well as seizures/epilepsy. These diseases inflict suffering by causing lifelong disabilities, reducing economic productivity, and causing social stigma. The complexity of parasitic life cycles and geographic specificities, as well as overlapping clinical manifestations in the host reflecting the diverse pathogenesis of parasites, can present diagnostic challenges. We herein provide an overview of these parasitic diseases and summarize clinical aspects, diagnosis, therapeutic strategies and recent milestones, and aspects related to prevention and control.

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Climate change and epilepsy: Time to take action

et al. 2019

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Climate change is the biggest challenge facing humanity today. The associated global warming and humidification, increases in the severity and frequency of extreme climate events, extension of the ranges of vector‐borne diseases, and the consequent social and economic stresses and disruption will have major negative consequences on many aspects of health care. People whose resilience to change is already impaired may suffer disproportionately from these environmental changes, which are of unprecedented reach and magnitude. There has been little connection made so far between climate change and epilepsy. We briefly review the history of climate change science and the subsequent response of the global scientific community. We consider how climate change effects might in general affect health and disease. We consider some of the underlying complex interactions that, for example, favor the spread of vector‐borne diseases and how climate models operate and may help plan for global and local changes. We then speculate specifically on how these generic ideas may apply specifically to epilepsy. We consider these impacts at levels from molecular to the epidemiological. Data are sparse, and there is undoubtedly a need for more information to enable better estimation of possible effects of climate change on care in epilepsy. We also consider how the professional activities of those involved in epilepsy health care might contribute to global carbon emissions, for example, through flying for conference attendance. Healthcare organizations across the world are already considering, and responding to, many of these issues. We argue for more research in this area, but also for action today. Actions today are likely to generate cobenefits for health care, including care in epilepsy, resulting from efforts to decarbonize, mitigate effects of climate change that has already happened, and plan for adaptation to climate change.

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Parasitic disorders

Cited by 8 publications

References 52 publications

Longer epilepsy duration and multiple lobe involvement predict worse seizure outcomes for patients with refractory temporal lobe epilepsy associated with neurocysticercosis

Longer epilepsy duration and multiple lobe involvement predict worse seizure outcomes for patients with refractory temporal lobe epilepsy associated with neurocysticercosis

Parasitic diseases of the central nervous system: lessons for clinicians and policy makers

Climate change and epilepsy: Time to take action

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