Parasitic Diseases

Dunn, Michael A.

doi:10.1002/9781119950509.ch39

Cited by 3 publications

(7 citation statements)

References 71 publications

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“…It is postulated that this may have been because the population that was studied is in a malaria endemic country and the size of the spleen could have been due to parasitic infections. Parasitic infections have been observed to cause increase to the weight of the spleen [13]. The weight of the spleen was 0.28% in males and 0.28% in females (Table 3).…”

Section: Discussionmentioning

confidence: 99%

Correlation of Internal Organ Weights with Body Weight and Body Height in Normal Adult Zambians: A Case Study of Ndola Teaching Hospital

Mubbunu

Bowa

Petrenko³

et al. 2018

Anatomy Research International

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The objective of the research was to study the correlation of internal organ weights with body weight and length in normal adult Zambians. The study involved 114 (83 males and 31 females) forensic autopsies from Ndola Teaching Hospital done over a period of 12 months. The cases included autopsies of unnatural deaths including road traffic accidents and homicide. Cases where information about age and origin of the person was not available were left out of the study. The age of the decedents ranged from 16 to 85 years. The data was analyzed by Pearson correlation coefficient to determine correlation. P values less than 0.05 were considered to be statistically significant. It was observed that the heart, liver, left kidney, right kidney, brain, and left lung were positively correlated to body weight, while only the brain and the left lung were positively correlated to the height in the male population. In the female population, the heart, liver, right kidney, brain, and right lung were positively correlated to the weight of the body, while only the right kidney was positively correlated to the height of the body.

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Section: Discussionmentioning

confidence: 99%

Correlation of Internal Organ Weights with Body Weight and Body Height in Normal Adult Zambians: A Case Study of Ndola Teaching Hospital

Mubbunu

Bowa

Petrenko³

et al. 2018

Anatomy Research International

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“…The liver is capable of hosting a wide range of parasites which vary in host cell requirement (extra or intracellular), sizes (unicellular to multicellular) and potential harm to the host cells or organs ( Dunn, 2011 ). Parasites which have co-evolved with humans through centuries, such as the malaria parasites cause minimal injury to the host liver and move on to the blood with ease ( Acharya et al, 2017 ).…”

Section: Drivers Of Liver Fibrosismentioning

confidence: 99%

“…Leishmania is an intracellular protozoan parasite that infects the reticuloendothelial system (RES) in the body, i.e., circulating monocytes as well as tissue-resident macrophages ( Magill et al, 1993 ). Leishmaniasis is transmitted by the bite of infected sandflies ( Dunn, 2011 ). Visceral leishmaniasis (kala-azar) involves the RES infection of the visceral organs like the liver, spleen, bone marrow and other lymph nodes.…”

Section: Drivers Of Liver Fibrosismentioning

confidence: 99%

Cellular Mechanisms of Liver Fibrosis

et al. 2021

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The liver is a central organ in the human body, coordinating several key metabolic roles. The structure of the liver which consists of the distinctive arrangement of hepatocytes, hepatic sinusoids, the hepatic artery, portal vein and the central vein, is critical for its function. Due to its unique position in the human body, the liver interacts with components of circulation targeted for the rest of the body and in the process, it is exposed to a vast array of external agents such as dietary metabolites and compounds absorbed through the intestine, including alcohol and drugs, as well as pathogens. Some of these agents may result in injury to the cellular components of liver leading to the activation of the natural wound healing response of the body or fibrogenesis. Long-term injury to liver cells and consistent activation of the fibrogenic response can lead to liver fibrosis such as that seen in chronic alcoholics or clinically obese individuals. Unidentified fibrosis can evolve into more severe consequences over a period of time such as cirrhosis and hepatocellular carcinoma. It is well recognized now that in addition to external agents, genetic predisposition also plays a role in the development of liver fibrosis. An improved understanding of the cellular pathways of fibrosis can illuminate our understanding of this process, and uncover potential therapeutic targets. Here we summarized recent aspects in the understanding of relevant pathways, cellular and molecular drivers of hepatic fibrosis and discuss how this knowledge impact the therapy of respective disease.

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“…The possible approaches for treating the hepatic hydatid cyst include antihelmintic chemotherapy, percutaneous drainage, and surgical resection [12]. The findings of physical and laboratory examination, abdominal imaging, endoscopy and liver biopsy revealed hepatitis B-related cirrhosis in presented case.…”

Section: Discussionmentioning

confidence: 80%

“…Furthermore, ELISA and indirect hem agglutination assays are the most useful diagnostic tools to determine the disease as well as to assess the viability of cysts. In case of involvement of the liver, sensitivity of the serologic tests is reported as substantially higher [10][11][12][13].…”

Section: Discussionmentioning

confidence: 99%

An Orient Triad With Hepatitis B Related Cirrhosis, Hydatid Cyst and Brucellosis: A Case Report

Dulger

2011

J Med Cases

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In many ways, diagnostic problems of the liver are different in Asian patients from those in western patients. Hepatitis B virus infection plays a major role for chronic liver disease worldwide as well as Turkey. One of the most feared complications of chronic hepatitis B is liver cirrhosis. Hydatid disease of the liver is one of the most common clinical problems in developing countries. Usually, the diagnosis is made by serology with ultrasonography. As a zoonotic disease, brucellosis can be coexisted with any of a number of clinical pictures and may mimic a variety of diseases. All of these different diseases may rarely present in the same patient. So, we report an unusual case of hydatide disease with hepatitis Brelated cirrhosis and brucellosis. Thus, we reviewed many critical issues on this case report on the role of diagnostic approaches and management.

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Parasitic Diseases

Cited by 3 publications

References 71 publications

Correlation of Internal Organ Weights with Body Weight and Body Height in Normal Adult Zambians: A Case Study of Ndola Teaching Hospital

Correlation of Internal Organ Weights with Body Weight and Body Height in Normal Adult Zambians: A Case Study of Ndola Teaching Hospital

Cellular Mechanisms of Liver Fibrosis

An Orient Triad With Hepatitis B Related Cirrhosis, Hydatid Cyst and Brucellosis: A Case Report

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