Parasites and immunotherapy: with or against?

Darani, Hossein Yousofi; Yousefi, Mohammad Reza; Safari, Marzieh; Jafari, Rasool

doi:10.1007/s12639-014-0533-4

Cited by 10 publications

(4 citation statements)

References 109 publications

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“…Also it has been show that Trypanosome cruzi can decrease tumor size in mice [18]. Anticancer effect of hydatid cyst antigens has been shown in different investigations [3][4][5][6]8,[19][20][21]. Yousofi et al [6] investigated the effect of protosculex of hydatid cyst on proliferation and death of fibrosarcoma and fiberblast cells.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effect of Hydatid Cyst Liquid on Melanoma Tumor Growth in Mouse Model

Darani

Sharafi

Mokarian

et al. 2016

BJMMR

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Introduction: Hydatid cyst is the larval stage of Echinococcus granulosus which develops in various human and livestock animals tissues. This hydatid cyst composed of several layers. Previous investigations have shown that the prevalence of hydatid cyst in cancer patients is significantly lower than in healthy individuals. In animal models preventive effect of the hydatid cyst antigens in reduction of tumor growth has been shown. Due to the effect of live protosculex and Original Research Articlehydatid cyst antigens on reducing the growth of cancer cells in culture medium, in this study therapeutic effect of hydatid cyst liquid on the growth of melanoma tumor in mice (C57 black) has been investigated. Methods: In this Experimental study, the population studies were C57 black mice. Six groups of mice were injected with 10 6 melanoma cells in their chest site subcutaneously. Then the mice were injected with hydatid cyst fluid either with or without albendazole. From the second week, the tumor size was measured using a calipers and tumor area was calculated and the mean tumor area compared with those of control groups using One-way ANOVA test. Results: The mean tumor area, in groups which injected with hydatid cyst fluid (case groups), was less than the mean tumor area in the control groups and this difference was statistically significant. Conclusion:This study showed that hydatid cyst fluid may have therapeutic effect on melanoma cancer growth.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Effect of Hydatid Cyst Liquid on Melanoma Tumor Growth in Mouse Model

Darani

Sharafi

Mokarian

et al. 2016

BJMMR

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“…The presence of Tn antigen in larval and adult tissues of E. granulosus was reported [52], this finding is interested in cancer-associated mucin-type because this parasite produced peptides can act on the nonspecific natural killer cell to express cytokines that are effective agents against tumor growth; therefore, the family of Tn antigens might be useful targets for antitumor immunotherapy [41,53,54]. These evidences may contribute to the design of tumor vaccines and open new horizons in the use of parasite-derived molecules that can fight against cancer [55,56].…”

Section: Using Parasite Productions For Cancer Treatmentmentioning

confidence: 99%

Current Research Advance on Echinococcosis

Yang¹,

Zhao²,

McManus³

et al. 2017

Echinococcosis

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Echinococcosis is caused by infection with larva (metacestode) of the tapeworms of the genus Echinococcus. Within genus Echinococcus, two species are known as public health concern worldwide: Echinococcus guanulosus causing cystic echinococcosis (CE) and Echinococcus multilocularis causing alveolar echinococcosis (AE). The co-evaluation due to the interaction between parasites and their hosts has been well known to be able to allow tolerating to maintain parasitism as long as possible. With many research advanced findings, scientists have been much interested in using either those molecules from parasites producing due to invading and surviving or those cytokines from hosts responding due to defenses to carry out immunotherapeutic practice that is not only against parasitic infection but also for cancer or other immunological related disorders. Taken advance of knowledge on Echinococcus genome research outcomes, recent attentions regarding the discoveries of targeting antiparasitic drug and/or vaccine were extensively discussed in this review.

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“…Specifically, parasites, by their capacity to modulate host immunity, have been hypothesized to play a potential role in modulating cancer immunotherapy. 84 …”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 99%

How the gut parasitome affects human health

Ianiro

Iorio

Porcari

et al. 2022

Therap Adv Gastroenterol

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The human gut microbiome (GM) is a complex ecosystem that includes numerous prokaryotic and eukaryotic inhabitants. The composition of GM can influence an array of host physiological functions including immune development. Accumulating evidence suggest that several members of non-bacterial microbiota, including protozoa and helminths, that were earlier considered as pathogens, could have a commensal or beneficial relationship with the host. Here we examine the most recent data from omics studies on prokaryota-meiofauna-host interaction as well as the impact of gut parasitome on gut bacterial ecology and its role as ‘immunological driver’ in health and disease to glimpse new therapeutic perspectives.

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Parasites and immunotherapy: with or against?

Cited by 10 publications

References 109 publications

Therapeutic Effect of Hydatid Cyst Liquid on Melanoma Tumor Growth in Mouse Model

Therapeutic Effect of Hydatid Cyst Liquid on Melanoma Tumor Growth in Mouse Model

Current Research Advance on Echinococcosis

How the gut parasitome affects human health

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