Parasitaemia Reduction and Moderately Improved Haematological Indices Potentials of Hippocratea Africana Root Bark Extract in Plasmodium Bergheiberghei Infected Mice

Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in <i>Plasmodium berghi-berghi</i> Infected Mice Treated with <i>Hippocratea africana</i> Root Bark Extract

“…Artemether-Lumefantrine is the world health organizations recommended first choice drug for treatment of malaria due to its high or near total clearance of the parasite. Ndem and Bassey [2], had reported that H. africana has significant antimalarial activity and the present study corroborates the report.…”

“…The roots were gently washed to get rid of debris. The root bark was processed to obtain crude extract according to the method described by Ndem and Bassey, [2017] [2]. The root bark was scrapped, cut into small pieces and pulverized.…”

“…Malaria parasite, Plasmodium berghi-berghi was obtained from the Department of Pharmacology, University of Uyo, Uyo, Nigeria through a donor mouse. The experimental animals in the present study were induced with malaria according to the method described by Ndem and Bassey [2]. The parasite was obtained from the donor mouse through cardiac puncture after being anaesthetized with chloroform.…”

“…Artemisinin-base combination therapies [ACTs] are recommended by the world health organization for effective management of malaria. However, the high cost of these drugs, unavailability and the emergence of drug resistance Plasmodium falciparum has left the poor masses completely reliant on natural herbal remedy with little or no cost and is readily available as well as well proven to be effective against malaria [2]. In addition, it has been observed that in the rural communities, patients who may be seeking quick healing tend to combine herbal therapies with conventional drugs for malaria treatment [3].…”

“…It is geographically distributed in tropical African countries like Nigeria, Ghana and Senegal [5,6] and is found to be rich in phytochemicals such as alkaloids, flavonoids, terpenes, tannins, cardiac glycosides and saponins. These phytochemicals are believed to be responsible for various biological activities such as antimicrobial, anti-inflammatory, anticancer and antimalarial activities [2,5,7].…”