Parascaris equorum in foals and in their environment on a Swedish stud farm, with notes on treatment failure of ivermectin

Lindgren, Kristina; Ljungvall, O.; Nilsson, Olle; Ljungström, Bitte; Lindahl, Cecilia; Höglund, Johan

doi:10.1016/j.vetpar.2007.10.014

Cited by 56 publications

(28 citation statements)

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“…Failure of macrocyclic lactone (ML) treatment to reduce the shedding of P. equorum eggs has been reported in several countries, such as the Netherlands (Boersema et al, 2002), Canada (Hearn and Peregrine, 2003), the United Kingdom (Stoneham and Coles, 2006), the United States (Craig et al, 2007), Denmark (Schougaard and Nielsen, 2007), Germany (von Samson-Himmelstjerna et al, 2007), Brazil (Molento et al, 2008), Sweden (Lindgren et al, 2008), Italy (Veronesi et al, 2009) and Finland (Näreaho et al, 2011). In ML-resistant populations of P. equorum, treatment with pyrantel pamoate, fenbendazole and oxibendazole has been successful (Slocombe et al, 2007;Lyons et al, 2008;Schougaard and Nielsen, 2007;Hearn and Peregrine, 2003).…”

Section: Introductionmentioning

confidence: 99%

Population genetics of Parascaris equorum based on DNA fingerprinting

Tydén

Morrison

Engström

et al. 2013

Infection, Genetics and Evolution

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Section: Introductionmentioning

confidence: 99%

Population genetics of Parascaris equorum based on DNA fingerprinting

Tydén

Morrison

Engström

et al. 2013

Infection, Genetics and Evolution

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“…Die verkürzte ERP wird im Zusammenhang mit dem Überleben des vierten Larvenstadiums gesehen (Lyons et al 2009(Lyons et al und 2010. Bei den Spulwürmern ist die Resistenz gegen die makrozyklischen Laktone während der vergangenen Jahre häufig beschrieben worden und offenbar weit verbreitet (Boersema et al 2002, Craig et al 2007, Hearn und Peregrine 2003, Kaplan et al 2006, Lindgren et al 2008, Lyons et al 2008a,b, Schougaard und Nielsen 2007, Slocombe et al 2007, Stoneham und Coles 2006, Veronesi et al 2009, Samson-Himmelstjerna et al 2007). …”

Section: Resistenzentwicklungunclassified

Current state of anthelmintic resistance in horses with a special focus on the situation in Germany

Ertelt¹,

Samson‐Himmelstjerna²,

Gehlen³

2016

PHK

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Current state of anthelmintic resistance in horses with a special focus on the situation in GermanyThe occurrence of anthelmintic resistance has been reported soon after the introduction of well tolerated broad-spectrum anthelmintics in the 1960s. Like in bacteria the development of resistance in gastro-intestinal parasites of equines is a consequence of repeated drug application and represents an evolutionary process. In Germany, resistance has been detected in small strongyles to benzimidazole (several studies with up to ca. 80 % resistance frequency) and tetrahydropyrimidine (several studies with up to ca. 25 % resistance frequency), in ascarids to macrocyclic lactones (single study on one farm) and recently in pinworms to ivermectin (macrocyclic lactone) (single study on one farm). Once anthelmintic resistance is established it remains in the worm population even if the particular drug class is not used over a longer period of time. Today different tests are available for detection of anthelmintic resistance. Despite limitations, the FECRT remains the test of choice in horses. Different worm control concepts have been established to delay the development of resistance. Any sustainable worm control strategy targets the least frequent application of anthelmintics that does not harm the health and well-being of the horse. The targeted selective treatment that has been developed for the prevention of anthelmintic resistance in small ruminants can only be used in horses with limitations and will be further discussed in this review.

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“…In the last decade, Parascaris spp. resistant to different groups of anthelmintics has been reported in horses in many countries such as the Netherlands (Boersema et al 2002), USA (Craig et al 2007), UK (Stoneham & Coles 2006), Canada (Hearn & Peregrine 2003;Slocombe et al 2007), Germany (von SamsonHimmelstjerna et al 2007), Sweden (Lindgren et al 2008), Italy (Veronesi et al 2010), France (Geurden et al 2013) and Australia (Armstrong et al 2014). Since chemical treatment is still the mainstay of parasite control measures, the detection of anthelmintic resistance in strongyles has become a critical necessity (Pook et al 2002;Wolstenholme et al 2004).…”

Section: Introductionmentioning

confidence: 99%

A field study on the anthelmintic resistance of Parascaris spp. in Arab foals in the Riyadh region, Saudi Arabia

Alanazi

Mukbel

Alyousif

et al. 2017

Veterinary Quarterly

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Background: In the last decade, Parascaris spp. resistance to anthelmintics has been recorded in many countries. In Saudi Arabia, there are limited data available on Parascaris spp. resistance to anthelmintics. Objective: To determine the current status of ivermectin, abamectin and praziquantel combined, and fenbendazole resistance to Parascaris spp. in horses in Saudi Arabia. Methods: Three hundred and forty-one foals from eleven different farms were examined by faecal egg count (FEC). The foals were all Arab horses aged 17.2 § 4.5 (SD) months. Ivermectin (n = 46 foals), abamectin and praziquantel combined (n = 46), and fenbendazole (n = 46) were administered on day 0 and faeces were collected on day 14. The study comprised 41 untreated foals as controls. Animals that have FEC of 100 eggs per gram (EPG) were used to measure anthelmintic efficacy. Parascaris spp. populations were considered susceptible when faecal egg count reduction (FECR) was 95% associated with a lower 95% confidence limit (LCL) >90%, suspected resistant when FECR 90% or LCL <90% and resistant when FECR <90% and LCL <90%. Results: Prevalence of Parascaris spp. infection was 53% (179/341 horses). Anthelmintic resistance to Parascaris spp. were highest following fenbendazole (55% of farms and 65% of foals) and to a lower extent following ivermectin or the combination of abamectin and praziquantel which comprised 27% of farms (and 46% of foals) and 18% of farms (and 10% of foals), respectively. Conclusion: These data indicate that anthelmintics-resistant Parascaris spp. populations are present on horse farms in Saudi Arabia.

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Parascaris equorum in foals and in their environment on a Swedish stud farm, with notes on treatment failure of ivermectin

Cited by 56 publications

References 10 publications

Population genetics of Parascaris equorum based on DNA fingerprinting

Population genetics of Parascaris equorum based on DNA fingerprinting

Current state of anthelmintic resistance in horses with a special focus on the situation in Germany

A field study on the anthelmintic resistance of Parascaris spp. in Arab foals in the Riyadh region, Saudi Arabia

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