Parasagittal meningioma en plaque with extracranial extension presenting diffuse massive hyperostosis of the skull

Do aggressive imaging features correlate with advanced histopathological grade in meningiomas?

“…12 In our series, hyperostosis was observed in 8.5% typical meningiomas and in no atypical meningiomas (p > 0.05). Several theories about the mechanism of hyperostosis have been proposed including: vascular disturbance of bone caused by the tumor; irritation of bone by tumor without invasion; stimulation of osteoblasts in the normal bone by factors secreted by the tumor cells; production of bone by the tumor itself; and, true tumor invasion of the bone.…”

Possible role of matrix metalloproteinases (MMPs) in hyperostosis of intracranial meningiomas

“…Many hypotheses regarding the mechanism underlying hyperostosis have been proposed, including prior trauma, vascular disturbances, stimulation of osteoblasts in the normal bone via humoral factors secreted by tumor cells, formation of bone by the tumor, irritation of the bone by the tumor without invasion, and tumor invasion of the bone [1,14,32]. Tumor invasion of the bone appears a generally accepted explanation for hyperostosis, as many cases with hyperostosis have revealed histological tumor cell infiltration of the bone [14].…”

Can 3T MR Angiography Replace DSA for the Identification of Arteries Feeding Intracranial Meningiomas?

“…In some earlier reports, the dural attachment of meningiomas was identified, and hyperostosis at the dural attachment site is a phenomenon recognized on CT scans. 19,20 A contrast-enhanced 3D MR technique (eg, fast imaging with steady-state acquisition) may provide information regarding the adhesiveness of dural attachments. 21 Because these are indirect radiologic findings, however, the accurate site at which tumor-feeding arteries enter the tumor via the attached dura mater is not fully understood.…”