Pararetroviruses: Plant Infecting dsDNA Viruses

Nasim, Noohi; Dey, Nrisingha

doi:10.1007/s11105-021-01294-7

Cited by 6 publications

(3 citation statements)

References 157 publications

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“…Transfer and expression of genes in plants can be achieved by agroinfiltration, viral transfection, transient expression, nuclear transformation etc. [ 62 ]. Plant viral vectors have also been engineered to produce pharmaceuticals.…”

Section: Plant Biopharmingmentioning

confidence: 99%

Plant-derived natural products for drug discovery: current approaches and prospects

Nasim

Sandeep

Mohanty

2022

Nucleus

120

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Nature has abundant source of drugs that need to be identified/purified for use as essential biologics, either individually or in combination in the modern medical field. These drugs are divided into small bio-molecules, plant-made biologics, and a recently introduced third category known as phytopharmaceutical drugs. The development of phytopharmaceutical medicines is based on the ethnopharmacological approach, which relies on the traditional medicine system. The concept of ‘one-disease one-target drug’ is becoming less popular, and the use of plant extracts, fractions, and molecules is the new paradigm that holds promising scope to formulate appropriate drugs. This led to discovering a new concept known as polypharmacology, where natural products from varying sources can engage with multiple human physiology targets. This article summarizes different approaches for phytopharmaceutical drug development and discusses the progress in systems biology and computational tools for identifying drug targets. We review the existing drug delivery methods to facilitate the efficient delivery of drugs to the targets. In addition, we describe different analytical techniques for the authentication and fingerprinting of plant materials. Finally, we highlight the role of biopharming in developing plant-based biologics.

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Section: Plant Biopharmingmentioning

confidence: 99%

Plant-derived natural products for drug discovery: current approaches and prospects

Nasim

Sandeep

Mohanty

2022

Nucleus

120

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“…However, the occurrence and distribution of DNA viruses in plants can also be influenced by several factors. For instance, pararetroviruses (PRVs, family Caulimovirida ) have wide geographical dissemination and invade a wide range of dicotyledonous and monocotyledonous plant species [ 64 ]. PRV infections can be both asymptomatic and symptomatic, and they can remain dormant in their host for an indefinite period, becoming active when confronted with specific stress [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

Deciphering the virome of Chunkung (Cnidium officinale) showing dwarfism-like symptoms via a high-throughput sequencing analysis

Belete,

Kim,

Gudeta

et al. 2024

Virol J

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Background Viruses have notable effects on agroecosystems, wherein they can adversely affect plant health and cause problems (e.g., increased biosecurity risks and economic losses). However, our knowledge of their diversity and interactions with specific host plants in ecosystems remains limited. To enhance our understanding of the roles that viruses play in agroecosystems, comprehensive analyses of the viromes of a wide range of plants are essential. High-throughput sequencing (HTS) techniques are useful for conducting impartial and unbiased investigations of plant viromes, ultimately forming a basis for generating further biological and ecological insights. This study was conducted to thoroughly characterize the viral community dynamics in individual plants. Results An HTS-based virome analysis in conjunction with proximity sampling and a tripartite network analysis were performed to investigate the viral diversity in chunkung (Cnidium officinale) plants. We identified 61 distinct chunkung plant-associated viruses (27 DNA and 34 RNA viruses) from 21 known genera and 6 unclassified genera in 14 known viral families. Notably, 12 persistent viruses (7 DNA and 5 RNA viruses) were exclusive to dwarfed chunkung plants. The detection of viruses from the families Partitiviridae, Picobirnaviridae, and Spinareoviridae only in the dwarfed plants suggested that they may contribute to the observed dwarfism. The co-infection of chunkung by multiple viruses is indicative of a dynamic and interactive viral ecosystem with significant sequence variability and evidence of recombination. Conclusions We revealed the viral community involved in chunkung. Our findings suggest that chunkung serves as a significant reservoir for a variety of plant viruses. Moreover, the co-infection rate of individual plants was unexpectedly high. Future research will need to elucidate the mechanisms enabling several dozen viruses to co-exist in chunkung. Nevertheless, the important insights into the chunkung virome generated in this study may be relevant to developing effective plant viral disease management and control strategies.

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“…eBSV is incorporated into the M. balbisiana (B) genome, and therefore is present in hybrids containing the B genome (eg, AAB). Although M. balbisiana is resistant to infection, AAB hybrids are susceptible [25]. Under stress conditions, the viral replication pathway is activated and the new infective BSV particles are able to avoid DNA cytosine methylation and transcriptional gene silencing, even after facing accumulation of siRNAs produced by the defense-response mechanism; this is supposed to explain why eBSV persist in its integrated form in plants [24,26], a challenge to biotechnological approaches.…”

Section: Bananamentioning

confidence: 99%

Tropical Fruit Virus Resistance in the Era of Next Generation Plant Breeding

Vieira,

Cabral,

Favaratto

et al. 2024

Preprint

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Plant viral diseases constitute a major contributor to agricultural production losses, significantly impacting the economies of exporting countries by more than $30 billion annually. Understanding and researching the biology and genomics of viruses is crucial for developing virus-resistant, genetically edited or genetically modified plants. Genetic modifications can be targeted to specific regions within genes of target plants which are important or essential for the virus to establish a systemic infection, thus fostering resistance or enabling plants to effectively respond to invading agents while preserving their yield. This review provides an overview of viral incidence and diversity in tropical fruit crops and aims to examine the current state of the knowledge on recent research efforts aimed at reducing or eliminating the damage caused by viral diseases, with emphasis on genetically edited products that have reached the market in recent years.

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Pararetroviruses: Plant Infecting dsDNA Viruses

Cited by 6 publications

References 157 publications

Plant-derived natural products for drug discovery: current approaches and prospects

Plant-derived natural products for drug discovery: current approaches and prospects

Deciphering the virome of Chunkung (Cnidium officinale) showing dwarfism-like symptoms via a high-throughput sequencing analysis

Tropical Fruit Virus Resistance in the Era of Next Generation Plant Breeding

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