Pararenal Leiomyosarcoma of the Inferior Vena Cava

Kwon, Tae-Won; Sung, Kyu Bo; Cho, Yong Pil; Kim, Do Kyun; Sun, Yang; Ro, Jae Y.; Kim, Geun Eun

doi:10.3346/jkms.2003.18.3.355

Cited by 29 publications

(40 citation statements)

References 4 publications

(7 reference statements)

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“…Vascular leiomyosarcoma constitutes about 2% of all leiomyosarcomas and involves veins five times more than arteries (1,2). The diagnosis of vascular leiomyosarcoma is often missed because the clinical manifestations are non-specific and vary widely according to the location of the tumor, and because no reliable tumor marker is available.…”

Section: Leiomyosarcoma Of the Abdominal Aorta: A Rare Cause Of Renovmentioning

confidence: 99%

“…Seitaro IGUCHI 1) , Bassam ALCHI 1) , Katsuaki ASAKAWA 1) , Daisuke IZUMI 2) , Takeshi KASHIMURA 2) , Mitsuhiro UENO 1) , Farah SAFAR 3) , Shinichi NISHI 1) , Ichiei NARITA 1) , and Fumitake GEJYO 1) Introduction Leiomyosarcoma is a rare malignant tumor originating from the smooth muscle cells. Vascular leiomyosarcoma constitutes about 2% of all leiomyosarcomas and involves veins five times more than arteries (1,2).…”

Section: Leiomyosarcoma Of the Abdominal Aorta: A Rare Cause Of Renovmentioning

confidence: 99%

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Leiomyosarcoma of the Abdominal Aorta: A Rare Cause of Renovascular Hypertension

et al. 2007

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Section: Leiomyosarcoma Of the Abdominal Aorta: A Rare Cause Of Renovmentioning

confidence: 99%

Section: Leiomyosarcoma Of the Abdominal Aorta: A Rare Cause Of Renovmentioning

confidence: 99%

Leiomyosarcoma of the Abdominal Aorta: A Rare Cause of Renovascular Hypertension

et al. 2007

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“…Greater than 50% of all vascular LMSs occur in the IVC. 1 Prognosis is often poor due to advanced stage at diagnosis. Surgical excision of the tumor and affected IVC with negative margins is the only treatment shown to improve survival.…”

mentioning

confidence: 99%

“…Surgical excision of the tumor and affected IVC with negative margins is the only treatment shown to improve survival. [1][2][3] Reconstruction of the IVC and other involved vessels is often required. There is no proven role for adjuvant treatment, and recurrence is common.…”

mentioning

confidence: 99%

Primary leiomyosarcoma of the inferior vena cava: Reports of infrarenal and suprahepatic caval involvement

Tameo

Calligaro

Antin

et al. 2010

Journal of Vascular Surgery

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We report two cases of primary inferior vena cava (IVC) leiomyosarcoma. The first patient was a 60-year-old female who presented with abdominal pain. The patient was initially diagnosed with a retroperitoneal sarcoma that may have involved the right renal vessels and the IVC. The Vascular Surgery Service was consulted intra-operatively when it became evident that the IVC was primarily involved. The patient was treated with total en-bloc excision of the infrarenal IVC tumor with concomitant interposition polytetrafluoroethylene (PTFE) graft caval replacement. The second patient was a 58-year-old female who presented with general malaise and anemia. This tumor began in the distal infrarenal IVC and extended cephalad to the suprahepatic IVC, ending approximately 2 cm below the right atrium. Intrapericardial IVC clamping was required for cephalad control in this patient, who was then treated with excision of the tumor and concomitant interposition PTFE graft caval replacement with reimplantation of the right renal vein. A review of this rare tumor is presented.

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“…Radical surgical resection remains the only proven therapeutic modality that prolongs the survival in patients with leiomyosarcoma. 15,20 Histological grade often correlates with biological behaviour and with prognosis. The principal sites of metastasis are lungs and liver; regional lymph node metastasis are rare.…”

Section: Case Reportmentioning

confidence: 99%

Primary Adrenal Leiomyosarcoma: A Case Report and Literature Review

Bergaglio

Truini²,

Varaldo

2008

Clinical medicine. Oncology

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Summary:The case presented here illustrates a 75 year old female patient who underwent surgical resection of a right adrenal mass of uncertain nature. The fi nal histological diagnosis was consistent with leiomyosarcoma arising from the adrenal anatomic site. Primary leiomyosarcoma of the adrenal gland is a very rare malignant mesenchymal neoplasm: to our knowledge, this is only the twelfth case reported in literature. We describe the clinical course and a brief review of clinical and histological features, biologic behaviour, diagnostic approaches and therapeutic strategies. Case ReportA 75-year-old white female was admitted to the Department of Urology of our hospital following the ultrasound fi nding of a right adrenal mass of uncertain nature. Her medical history was unremarkable, except for long-term essential arterial hypertension. For a month prior to hospitalization the patient had complained of persistent and progressive epigastric and right loin pain. Physical examination showed only mild abdominal discomfort at palpation. No enlarged lymph nodes were present. Laboratory tests detected no abnormalities. Urinary levels of vanilmandelic acid, catecolamines and plasmatic level of aldosterone were normal.Chest radiograph and electrocardiogram revealed no pathological fi ndings. Upper gastrointestinal endoscopy detected oesophageal hiatal hernia with refl ux oesophagitis, and total-body CT confi rmed the presence of a right adrenal mass of about 5 × 4 cm, suspected to be an adrenal carcinoma, so radical surgery was planned and performed with the resection of a roundish formation from the adrenal anatomic site. Normal adrenal gland was not visible (Fig. 1).Three days after surgery the patient developed a pulmonary embolism: an inferior vena cava thrombosis was identifi ed by angio-CT scan. Pulmonary embolism was identifi ed by angio-CT scan, too. Moreover, an unexplained progressive drop of hemoglobin concentration down to 7.7 g/dl, requiring infusion of two units of packed red cells, was observed. The patient was transferred to our Intensive Care Unit, where she received routine treatment for pulmonary embolism including anticoagulant therapy fi rst with intravenous heparin and then with warfarin.The clinical course was satisfactory, and subsequent Doppler-ultrasonography confi rmed the return to normal of venous fl ow through inferior vena cava. The patient, clinically stable with a good cardiorespiratory compensation, was discharged on postoperative day 18; continuation of anticoagulant therapy and physical rehabilitation were recommended. No oncological treatment was provided after surgery, and no evidence of recurrent disease was observed one year later.Gross pathological examination of the resected tissue showed a roundish, fi brous neoformation of 8 × 4 × 5 cm. A thrombus was detected inside the adrenal vein; this thrombus was not visible on CT performed before surgery. On sectioning of the mass, no adrenal structure was recognizable. Resection margins were free of disease. Histologically, tissue sect...

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Pararenal Leiomyosarcoma of the Inferior Vena Cava

Cited by 29 publications

References 4 publications

Leiomyosarcoma of the Abdominal Aorta: A Rare Cause of Renovascular Hypertension

Leiomyosarcoma of the Abdominal Aorta: A Rare Cause of Renovascular Hypertension

Primary leiomyosarcoma of the inferior vena cava: Reports of infrarenal and suprahepatic caval involvement

Primary Adrenal Leiomyosarcoma: A Case Report and Literature Review

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