Paraquat (PQ)-induced pulmonary fibrosis increases exercise metabolic cost, reducing aerobic performance in rats

Abstract

-Rats exposed to the quaternary herbicide paraquat (PQ) exhibit oxidative stress and lung injury. In the present study, we investigated the effect of multiple exposures to PQ on aerobic performance during progressive exercise on a treadmill in rats. PQ was dissolved in saline (SAL) (10 mg/ml) and administered intraperitoneally 7 mg/kg body wt to Wistar rats (n = 5) once a week for one month. Control rats received SAL (0.7 ml/kg body wt., intraperitoneally, n = 5) over the same time period. The animals were submitted to aerobic evaluation on a treadmill using a progressive protocol until fatigue prior to the removed and divided in two groups: PQ and SAL for histopathological analysis. The animals exposed to -gen consumption during exercise in comparison to the controls forty days after the last dose of PQ. Lung -parenchyma were higher in PQ compared to SAL. In conclusion, multiple exposures to PQ induce pulmoof exercise in rats.

Acute paraquat exposure determines dose‐dependent oxidative injury of multiple organs and metabolic dysfunction in rats: impact on exercise tolerance

“…Although O 2 consumption was not investigated, the marked lung injury (especially lung oedema, alveolar inflammatory infiltration and collapse) is coherent with an impaired gas exchange (Weibel ; Piantadosi & Schwartz ; Lacerda et al . ). Thus, under the conditions of limited O 2 rate, metabolic deviation towards a more active anaerobic component also represents a typical physiological strategy to ensure an adequate energy production (Wasserman et al .…”

“…These cells were evaluated in a test area of 3.4 × 10 3 μm 2 at the magnification of ×1000 across 10 random, non‐coincident microscopic fields of each animal (Lacerda et al . ). Forty random fields from each staining method and group were analysed with ×20 objective lens.…”

Redox-sensitive glycogen synthase kinase 3β-directed control of mitochondrial permeability transition: rheostatic regulation of acute kidney injury

“…The high mortality (>50%) is due to inherent toxicity and lack of effective treatments [48-50]. Though paraquat is rapidly distributed to various tissues after ingestion, concentrations accumulating within the kidneys are the highest [51].…”

Paraquat application and respiratory health effects among South Korean farmers

“…Paraquat is also known to increase the connective tissue growth factor and collagen expression by activating angiotensin signalling pathways in human fibroblasts 15. Pulmonary fibrosis induced by paraquat increases oxygen consumption, especially during exercise, and reduces aerobic performance in rats 16. Previous clinical findings among patients with paraquat poisoning have demonstrated a decrease in carbon monoxide diffusing capacity and restriction manifestation of FVC and FEV 1 after intoxication 4…”