Paraquat Ingestion: A Challenging Diagnosis

Chen, Jerome Gene; Eldridge, David L.; Lodeserto, Frank; Ming, David; Turner, Kristen M.; Vanderford, Joel L.; Sporn, Thomas A.; Schulman, Scott R.

doi:10.1542/peds.2009-2601

Cited by 18 publications

(14 citation statements)

References 19 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…-phase précoce avec lésions caustiques (douleurs pharyngées et abdominales, vomissements et intolérance digestive) ; -phase de cytolyse hépatique et d'insuffisance rénale tubulaire aiguë à partir de J1, pouvant conduire au décès par défaillance multiviscérale ; -phase de fibrose pulmonaire entre J5 et J20, conduisant parfois à un syndrome de détresse respiratoire aiguë puis au décès du patient en quelques semaines [12].…”

Section: Discussionunclassified

“…Cependant, en l'absence d'alternative thérapeutique validée, il est préférentiellement utilisé en France d'outre-mer, pour limiter le nombre de dé-cès par fibrose. L'ultime recours en cas de fibrose pulmonaire grave reste la greffe pulmonaire mais son succès est aléa-toire [2,12]. Certaines publications font état de travaux en cours sur d'autres molécules, comme des antioxydants tels que la N-acétylcystéine, la vitamine C, l'acide salicylique, la défé-roxamine ou encore l'ambroxol [15,[19][20][21].…”

Section: Discussionunclassified

See 1 more Smart Citation

Intoxications au paraquat en Guyane française : utilisation persistante lors de comportements suicidaires en outre-mer

Kervégant

Schmitt

Martin³

et al. 2013

Ann Toxicol Anal

View full text Add to dashboard Cite

Résumé -Mots clés : Paraquat, insuffisance rénale, cytolyse, fibrose pulmonaire, Guyane Abstract -Objective: Paraquat is a pesticide widely used around the world as herbicide. The toxicity of this molecule on human beings is high as it induces after ingestion liver and renal failure with possible delayed pulmonary fibrosis. After numerous reports about this major toxicity the European authorities decided to withdraw this herbicide of the market in July 2007. The authors report a collective case of poisoning with paraquat in French Guiana in 2011. Method: A teenager boy and his mother ingested paraquat deliberately. Hepatic and renal failures were observed for the young male who was treated with the immunosuppressive protocol treatment in order to prevent the pulmonary complications. His mother rapidly developed multi-organic failure. Results: The young boy's hepatic and renal failure evolved quickly favorably. No respiratory disturbances were reported with him allowing a discharge after 16 days of hospitalization. His mother who ingested higher quantities of paraquat died in 2 days. Conclusion: This collective case proves that 4 years after the prohibition of paraquat in French Guiana it is still possible to observe life-threatening poisonings induced by such a dangerous herbicide.

show abstract

Section: Discussionunclassified

Intoxications au paraquat en Guyane française : utilisation persistante lors de comportements suicidaires en outre-mer

Kervégant

Schmitt

Martin³

et al. 2013

Ann Toxicol Anal

View full text Add to dashboard Cite

show abstract

“…The general population of industrialized countries is exposed to pesticide residues mainly through the diet (Melnyk and others ). Moreover, accidental poisonings caused by these toxic compounds occur among children and farmers (Peiró and others ; Chen and others ).…”

Section: The Possibility Of Using a Melanocarpa Berries And Their Prmentioning

confidence: 99%

“…This compound is characterized by high toxicity to humans and animals related to its redox activity (Dou and others ). Exposure to this xenobiotic leads to liver (Peiró and others ) and lung damage (Chen and others ). Moreover, this compound has been recognized to contribute to the development of Parkinson's disease (Chen and others ).…”

Section: The Possibility Of Using a Melanocarpa Berries And Their Prmentioning

confidence: 99%

Chokeberries (Aronia melanocarpa) and Their Products as a Possible Means for the Prevention and Treatment of Noncommunicable Diseases and Unfavorable Health Effects Due to Exposure to Xenobiotics

Borowska

Brzóska

2016

Comp Rev Food Sci Food Safe

102

155

View full text Add to dashboard Cite

Aronia melanocarpa berries (chokeberries) constitute a very rich source of numerous substances exerting a beneficial impact on health, including mainly polyphenols (proanthocyanidins, anthocyanins, flavonoids, and phenolic acids), possessing antioxidative, anti-inflammatory, antiviral, anticancer, antiatherosclerotic, hypotensive, antiplatelet, and antidiabetic properties. Thus, the consumption of products made from chokeberries is of vital importance for health maintenance and protection. Nowadays, due to the growing prevalence of noncommunicable diseases and ubiquitous human exposure to numerous man-made and naturally occurring toxic substances, some of which are dangerous even at low amounts, it is very important to look for effective means of health protection. An important role in this regard may be played by A. melanocarpa berries; however, up to now the attention of scientists, nutritionists, and health practitioners has been focused mainly on the effectiveness of chokeberry products in the prevention and treatment of noncommunicable diseases, while only little attention has been paid to the possibility of their use to counteract the adverse health effects of exposure to xenobiotics. That is why in this review article the main interest has been focused on the possibility of using chokeberries in the protection against unfavorable health effects caused by the action of substances to which humans may be exposed environmentally and/or occupationally. The available experimental data indicate that not only the fruit but also the leaves of A. melanocarpa and their products may be effective means for prevention and treatment of the effects of toxic action of some xenobiotics in humans; however, further studies on this subject are necessary.

show abstract

“…PQ-induced acute lung injury (ALI) involves early acute pulmonary edema, pulmonary congestion, acute respiratory distress syndrome and advanced progressive pulmonary fibrosis. 3,4 The mortality rate of PQ poisoning is as high as 60%-80%, which is due to lack of an antidote for its specific effects. 5 Thus, it is important to study the mechanism…”

Section: Introductionmentioning

confidence: 99%

Porous Se@SiO<sub>2</sub> nanospheres treated paraquat-induced acute lung injury by resisting oxidative stress

Zhu¹,

Deng²,

Ji³

et al. 2017

IJN

View full text Add to dashboard Cite

Acute paraquat (PQ) poisoning is one of the most common forms of pesticide poisoning. Oxidative stress and inflammation are thought to be important mechanisms in PQ-induced acute lung injury (ALI). Selenium (Se) can scavenge intracellular free radicals directly or indirectly. In this study, we investigated whether porous Se@SiO 2 nanospheres could alleviate oxidative stress and inflammation in PQ-induced ALI. Male Sprague Dawley rats and RLE-6TN cells were used in this study. Rats were categorized into 3 groups: control (n=6), PQ (n=18), and PQ + Se@SiO 2 (n=18). The PQ and PQ + Se@SiO 2 groups were randomly and evenly divided into 3 sub-groups according to different time points (24, 48 and 72 h) after PQ treatment. Porous Se@SiO 2 nanospheres 1 mg/kg (in the PQ + Se@SiO 2 group) were administered via intraperitoneal injection every 24 h. Expression levels of reduced glutathione, malondialdehyde, superoxide dismutase, reactive oxygen species (ROS), nuclear factor-κB (NF-κB), phosphorylated NF-κB (p-NF-κB), tumor necrosis factor-α and interleukin-1β were detected, and a histological analysis of rat lung tissues was performed. The results showed that the levels of ROS, malondialdehyde, NF-κB, p-NF-κB, tumor necrosis factor-α and interleukin-1β were markedly increased after PQ treatment. Glutathione and superoxide dismutase levels were reduced. However, treatment with porous Se@SiO 2 nanospheres markedly alleviated PQ-induced oxidative stress and inflammation. Additionally, the results from histological examinations and wet-to-dry weight ratios of rat lung tissues showed that lung damage was reduced after porous Se@SiO 2 nanosphere treatment. These data indicate that porous Se@SiO 2 nanospheres may reduce NF-κB, p-NF-κB and inflammatory cytokine levels by inhibiting ROS in PQ-induced ALI. This study demonstrates that porous Se@SiO 2 nanospheres may be a therapeutic method for use in the future for PQ poisoning.

show abstract

Paraquat Ingestion: A Challenging Diagnosis

Cited by 18 publications

References 19 publications

Intoxications au paraquat en Guyane française : utilisation persistante lors de comportements suicidaires en outre-mer

Intoxications au paraquat en Guyane française : utilisation persistante lors de comportements suicidaires en outre-mer

Chokeberries (Aronia melanocarpa) and Their Products as a Possible Means for the Prevention and Treatment of Noncommunicable Diseases and Unfavorable Health Effects Due to Exposure to Xenobiotics

Porous Se@SiO<sub>2</sub> nanospheres treated paraquat-induced acute lung injury by resisting oxidative stress

Contact Info

Product

Resources

About