Paraquat exposure and Parkinson’s disease: A systematic review and meta-analysis

Tangamornsuksan, Wimonchat; Lohitnavy, Ornrat; Sruamsiri, Rosarin; Chaiyakunapruk, Nathorn; Scholfield, C. Norman; Reisfeld, Brad; Lohitnavy, Manupat

doi:10.1080/19338244.2018.1492894

Cited by 70 publications

(42 citation statements)

References 62 publications

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“…Regarding the frequency of application, 11% of farmers apply glyphosate once a month, 17% once every 15 days, 17% apply 2–3 times a week, 22% apply once a week and the highest percentage number were those who apply daily (28%). All farmers mix glyphosate with other pesticides and herbicides, mainly 2,4-D and paraquat; the exposure of these two pesticides, along with glyphosate, is of great importance and generates more significant interest in studying their presence and distribution because of the toxicity and public health implications they produce, since exposure to Paraquat and 2,4-D has been reported to represent a risk in Parkinson’s disease and non-Hodgkin’s lymphoma, respectively [ 45 , 46 ]. Moreover, 50% of them mentioned the necessity of these mixtures because of the increasing resistance of weeds.…”

Section: Resultsmentioning

confidence: 99%

Determination of Glyphosate in Water from a Rural Locality in México and Its Implications for the Population Based on Water Consumption and Use Habits

Reynoso

Peña

Reyes

et al. 2020

IJERPH

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Glyphosate is a broad-spectrum herbicide widely used worldwide. Indeed, it is the herbicide most applied to all Mexican crops. Due to the overuse and poor disposal of the waste, this herbicide can reach the aquatic environments such as groundwater and surface water. Thus, there is a clear need to implement monitoring and surveillance programs for evaluating and controlling the exposure to this herbicide in rural populations. The goal of this study was to quantify the presence of glyphosate in different water bodies (groundwater, surface and drinking water) as well as to identify the uses and managements of water resources by rural communities to evaluate the potential human exposure to glyphosate in the Tenampulco region of the Mexican state of Puebla. Measurements were performed by a rapid and cost-effective ELISA-based method in groundwater and surface water from various sampling sites of the Tenampulco region. Glyphosate was detected in all groundwater samples to be below the maximum limit for glyphosate in water in Mexico. Nevertheless, these results indicate an exposure of glyphosate in these agricultural communities and the need to establish a monitoring program.

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Section: Resultsmentioning

confidence: 99%

Determination of Glyphosate in Water from a Rural Locality in México and Its Implications for the Population Based on Water Consumption and Use Habits

Reynoso

Peña

Reyes

et al. 2020

IJERPH

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“…It was first discovered in 1985 in a frog study that paraquat triggers dopamine reduction and behavioral changes, similar to the effects seen in MPTP-induced models (Barbeau et al, 1985). Although both MPTP and paraquat prompt similar physiological effects, their mechanism of action is different, because unlike the lipophilic MPTP, paraquat is hydrophilic and thus, unable to passively cross the BBB (Tangamornsuksan et al, 2019;Vaccari et al, 2019). In this regard, the translocation of paraquat from outside to inside of the CNS might occur via an uncharged amino acid transporter (Tangamornsuksan et al, 2019).…”

Section: Paraquatmentioning

confidence: 97%

“…Although both MPTP and paraquat prompt similar physiological effects, their mechanism of action is different, because unlike the lipophilic MPTP, paraquat is hydrophilic and thus, unable to passively cross the BBB (Tangamornsuksan et al, 2019;Vaccari et al, 2019). In this regard, the translocation of paraquat from outside to inside of the CNS might occur via an uncharged amino acid transporter (Tangamornsuksan et al, 2019). Inside the CNS, paraquat in the form of di-cation crosses the membrane of inner mitochondria and is further reduced to mono-cation.…”

Section: Paraquatmentioning

confidence: 99%

The Promise of the Zebrafish Model for Parkinson’s Disease: Today’s Science and Tomorrow’s Treatment

et al. 2021

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The second most prevalent neurodegenerative disorder in the elderly is Parkinson’s disease (PD). Its etiology is unclear and there are no available disease-modifying medicines. Therefore, more evidence is required concerning its pathogenesis. The use of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is the basis of most animal models of PD. MPTP is metabolized by monoamine oxidase B (MAO B) to MPP + and induces the loss of dopaminergic neurons in the substantia nigra in mammals. Zebrafish have been commonly used in developmental biology as a model organism, but owing to its perfect mix of properties, it is now emerging as a model for human diseases. Zebrafish (Danio rerio) are cheap and easy to sustain, evolve rapidly, breed transparent embryos in large amounts, and are readily manipulated by different methods, particularly genetic ones. Furthermore, zebrafish are vertebrate species and mammalian findings obtained from zebrafish may be more applicable than those derived from genetic models of invertebrates such as Drosophila melanogaster and Caenorhabditis elegans. The resemblance cannot be taken for granted, however. The goal of the present review article is to highlight the promise of zebrafish as a PD animal model. As its aminergic structures, MPTP mode of action, and PINK1 roles mimic those of mammalians, zebrafish seems to be a viable model for studying PD. The roles of zebrafish MAO, however, vary from those of the two types of MAO present in mammals. The benefits unique to zebrafish, such as the ability to perform large-scale genetic or drug screens, should be exploited in future experiments utilizing zebrafish PD models.

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“…A recent meta-analysis of several case-control studies found that paraquat exposure was associated with a 1.64 times increased risk of developing PD [5]. In addition to paraquat, subsequent studies, systematic reviews, and meta-analyses have suggested that a wide range of pesticides (including rotenone, maneb, organochlorines, and organophosphates) are associated with an increased risk of PD [6].…”

Section: Introductionmentioning

confidence: 99%

Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: an observational study in southern Brazil

et al. 2020

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Background: Multiple studies have suggested that various pesticides are associated with a higher risk of developing Parkinson's disease (PD) and may influence the progression of the disease. However, the evidence regarding the impact of pesticide exposure on mortality among patients with PD is equivocal. This study examines whether pesticide exposure influences the risk of mortality among patients with PD in Southern Brazil. Methods: A total of 150 patients with idiopathic PD were enrolled from 2008 to 2013 and followed until 2019. In addition to undergoing a detailed neurologic evaluation, patients completed surveys regarding socioeconomic status and environmental exposures. Results: Twenty patients (13.3%) reported a history of occupational pesticide exposure with a median duration of exposure of 10 years (mean = 13.1, SD = 11.2). Patients with a history of occupational pesticide exposure had higher UPDRS-III scores, though there were no significant differences in regards to age, sex, disease duration, Charlson Comorbidity Index, and age at symptom onset. Patients with occupational pesticide exposure were more than twice as likely to die than their unexposed PD counterparts (HR = 2.32, 95% CI [1.15, 4.66], p = 0.018). Occupational pesticide exposure was also a significant predictor of death in a cox-proportional hazards model which included smoking and caffeine intake history (HR = 2.23, 95% CI [1.09, 4.59], p = 0.03)) and another which included several measures of socioeconomic status (HR = 3.91, 95% CI [1.32, 11.58], p = 0.01). Conclusion: In this prospective cohort study, we found an increased all-cause mortality risk in PD patients with occupational exposure to pesticides. More studies are needed to further analyze this topic with longer follow-up periods, more detailed exposure information, and more specific causes of mortality.

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Paraquat exposure and Parkinson’s disease: A systematic review and meta-analysis

Cited by 70 publications

References 62 publications

Determination of Glyphosate in Water from a Rural Locality in México and Its Implications for the Population Based on Water Consumption and Use Habits

Determination of Glyphosate in Water from a Rural Locality in México and Its Implications for the Population Based on Water Consumption and Use Habits

The Promise of the Zebrafish Model for Parkinson’s Disease: Today’s Science and Tomorrow’s Treatment

Occupational pesticide exposure and the risk of death in patients with Parkinson’s disease: an observational study in southern Brazil

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