Paraproteinemia and serum protein electrophoresis interpretation

What Do the Elevated Protein Levels Mean in My Patients with Myeloma, Amyloidosis, and Related Disorders?

“…These clonal proliferations encompass a spectrum of premalignant and malignant states. 1,2 The pathogenesis of diseases associated with monoclonal gammopathies is heterogenous and complex. Mature B-cell and plasma cell malignancies often lead to sequelae related to infiltration of tissues by malignant cells as well as the deposition or aggregation of the paraproteins themselves (Figure 1).…”