Paraproteinaemia in Sézary Syndrome

Abstract

We have observed non-myelomatous monoclonal hypergammaglobulinaemia in a 61-year-old man with Sézary syndrome. Similar cases have not been reported before. Sézary cells of patients studied by other investigators were found to be helper T cells. The abundant production of T-lymphocytic stimuli may possibly explain in our case the occurrence of a paraprotein.

Mycosis fungoides and lymphoplasmacytoid immunocytoma in the same patient

“…2 Consistent with the helper concept is the occurrence of hypergammaglobulinemia, dysglobulinemia, and even monoclonal gammopathy in CTCL. [26][27][28][29][30][31][32][33][34][35] Still more spectacular are the reports of multiple myeloma in a patient with Sezary's ~y n d r o m e~~.~~ and the association of MF with Mediterranean lymphoma described by Cassuto et all6 These authors also suggested that the B-cell lymphoma might possibly be related to the function of the malignant helper T-cells or to the T-helper/T-suppressor imbalance, or that eventually both diseases might be related to a common cause. Others38 who reported the association of MF with Hodgkin's disease have suggested that the uncontrolled proliferation of a population of Tcells might have a detrimental influence on the immune system, favoring the development of the second disease.…”