Paraprobiotic obtained by ohmic heating added in whey-grape juice drink is effective to control postprandial glycemia in healthy adults

Barros, Cássia Pereira; Grom, Laís C.; Guimarães, Jonas T.; Balthazar, Celso F.; Rocha, Ramon S.; Silva, Ramón; Almada, Caroline N.; Pimentel, Tatiana Colombo; Venâncio, Elisa L.; Collopy, Itallo; Maciel, Paula Maria Cals Theophilo; Freitas, Mônica Q.; Esmerino, Erick A.; Silva, Márcia C.; Duarte, Maria Carmela K.H.; Sant’Ana, Anderson S.; Cruz, Adriano G.

doi:10.1016/j.foodres.2020.109905

Cited by 32 publications

(23 citation statements)

References 29 publications

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“…The inactivation methods included heat, pressure, irradiation, and ohmic treatments. Only two studies [ 25 , 85 ] confirmed the absence of viable microbial cells in the preparations with inanimate preparations by culture-based analysis (plate count), and only two studies described changes in the GM [ 25 , 120 ]. A first study evaluated a live and inanimate multi-species probiotic and observed that both formulas were effective in reducing FBG, improving glucose tolerance, protecting pancreatic cells, and altering the intestinal tract modifying enteroendocrine cells, intestinal microbiota, and SCFA levels [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

“…We identified two human trials. The first study was a randomised and controlled crossover study, and it was performed in a reduced sample of healthy individuals; the findings indicate that the intake of live or inanimate Lacticaseibacillus casei 01 in a whey-grape juice with white bread can attenuate the glucose response expected [ 85 ]. Both formulas had an impact similar to the control drink (water), especially the inanimate probiotic preparation.…”

Section: Resultsmentioning

confidence: 99%

“…In the future, researchers must provide a mechanistic basis for the effects of a given postbiotic, and the clinical benefits will ultimately be shown by well-designed double-blind, randomised, placebo-controlled trials. Human data on postbiotics and DM are lacking, and we identified only one trial on this topic in healthy adults [ 85 ]. It is likely that ethnic group [ 138 , 139 ], sex [ 140 ], and the time course of DM [ 141 ] influence the GM response to postbiotic treatments, and these aspects should be contemplated in human studies.…”

Section: Discussionmentioning

confidence: 99%

“…Although probiotics [ 77 , 78 ], prebiotics [ 79 ], and fermented foods [ 80 , 81 , 82 ] have served as a reference for microbiome-based interventions, postbiotics are emerging potential agents for DM prevention or management. Good evidence for this can be found in experimental studies in different models of diabetes mellitus [ 83 , 84 ] and few human trials [ 85 ], as discussed below.…”

Section: Introductionmentioning

confidence: 99%

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Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives

Cabello-Olmo

Araña

Urtasun

et al. 2021

Foods

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In the last decade, the gastrointestinal microbiota has been recognised as being essential for health. Indeed, several publications have documented the suitability of probiotics, prebiotics, and symbiotics in the management of different diseases such as diabetes mellitus (DM). Advances in laboratory techniques have allowed the identification and characterisation of new biologically active molecules, referred to as “postbiotics”. Postbiotics are defined as functional bioactive compounds obtained from food-grade microorganisms that confer health benefits when administered in adequate amounts. They include cell structures, secreted molecules or metabolic by-products, and inanimate microorganisms. This heterogeneous group of molecules presents a broad range of mechanisms and may exhibit some advantages over traditional “biotics” such as probiotics and prebiotics. Owing to the growing incidence of DM worldwide and the implications of the microbiota in the disease progression, postbiotics appear to be good candidates as novel therapeutic targets. In the present review, we summarise the current knowledge about postbiotic compounds and their potential application in diabetes management. Additionally, we envision future perspectives on this topic. In summary, the results indicate that postbiotics hold promise as a potential novel therapeutic strategy for DM.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives

Cabello-Olmo

Araña

Urtasun

et al. 2021

Foods

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“…Very recently, Barros et al proposed a whey-grape juice drink containing paraprobiotic Lacticaseibacillus casei 01 inactivated by ohmic heating. Interestingly, this drink exhibited hypoglycemic activity in vitro (through the inhibition of α-glucosidase and α-amylase) and was effective in reducing postprandial glycemia in healthy individuals [ 90 ].…”

Section: Paraprobiotics Vs Probiotics In Functional Non-dairy Products and Nutraceuticalsmentioning

confidence: 99%

Paraprobiotics: A New Perspective for Functional Foods and Nutraceuticals

et al. 2021

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Probiotics are live microorganisms that confer health benefits on the host. However, in recent years, several concerns on their use have been raised. In particular, industrial processing and storage of probiotic products are still technological challenges as these could severely impair cell viability. On the other hand, safety of live microorganisms should be taken into account, especially when administered to vulnerable people, such as the elderly and immunodeficient individuals. These drawbacks have enhanced the interest toward new products based on non-viable probiotics such as paraprobiotics and postbiotics. In particular, paraprobiotics, defined as “inactivated microbial cells (non-viable) that confer a health benefit to the consumer,” hold the ability to regulate the adaptive and innate immune systems, exhibit anti-inflammatory, antiproliferative and antioxidant properties and exert antagonistic effect against pathogens. Moreover, paraprobiotics can exhibit enhanced safety, assure technological and practical benefits and can also be used in products suitable for people with weak immunity and the elderly. These features offer an important opportunity to prompt the market with novel functional foods or nutraceuticals that are safer and more stable. This review provides an overview of central issues on paraprobiotics and highlights the urgent need for further studies aimed at assessing safety and efficacy of these products and their mechanisms of action in order to support decisions of regulatory authorities. Finally, a definition is proposed that unambiguously distinguishes paraprobiotics from postbiotics.

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Functional assessments of Psidium guajava L. and Morus alba L. leaf extracts on postprandial glucose control

Hsu,

Chen,

Hsieh

et al. 2024

Food Science & Nutrition

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Diabetes is a leading cause of death, according to statistics published by the Department of Health, Executive Yuan of Taiwan. In modern medicine, diabetes can be controlled using various medications; however, some drugs often have undesirable side effects. It therefore became a goal to find plant‐based material that can reduce glucose concentration in the blood while reducing the incidence of complications and not causing side effects. Alpha‐glucosidase inhibitors (AGIs) are effective glucose‐lowering medicines and are enzymes essential to carbohydrate digestion. Inhibition of α‐glucosidase leads to a delayed and reduced rise in postprandial blood glucose levels. This study evaluates the inhibitory effect of mixed extracts of Psidium guajava L. and Morus alba L. leaves on α‐glucosidase activity and postprandial hyperglycemia in normal and diabetic rats. The inhibition of α‐glucosidase activity was assayed in vitro. Half maximal inhibitory concentration (IC50) values of Psidium guajava L. and Morus alba L. were 2.25 and 0.1 mg/mL, respectively. The IC50 value of a commercial anti‐hyperglycemic agent (Glucobay) is 6.41 mg/mL. The IC50 value of a mixture of extracts of Psidium guajava L. and Morus alba L. was 0.07 mg/mL. In cytotoxicity tests, survival percentages and shape did not significantly affect the murine embryonic liver cell line (BNL CL.2) when treated with varying concentrations of mixture extracts for varying periods of time. In summary, Psidium guajava L. and Morus alba L. showed positive anti‐diabetes activity and suggested promising potential for alternative functional foods for diabetes mellitus (DM) patients.

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Paraprobiotic obtained by ohmic heating added in whey-grape juice drink is effective to control postprandial glycemia in healthy adults

Cited by 32 publications

References 29 publications

Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives

Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives

Paraprobiotics: A New Perspective for Functional Foods and Nutraceuticals

Functional assessments of Psidium guajava L. and Morus alba L. leaf extracts on postprandial glucose control

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