Abstract:Spastic Paraparesis is related to multiple etiologies and a wide diagnosis screening must be accomplished. The B12 deficiency is an important metabolic cause of spastic paraparesis associated with cordonal posterior syndrome, named subacute spinal degeneration. The vitamin B12 deficiency can be associated with autoimmune pathophysiology and when combined with autoimmune thyroid impairment, the diagnosis of Polyglandular
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