Paraphenylenediamine Induced Acute Tubular Necrosis Following Hair Dye Ingestion

Suliman, Salma Mohamed; Homeida, M.; Aboud, O.I.

doi:10.1177/096032718300200408

Cited by 31 publications

(17 citation statements)

References 3 publications

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“…Angioneurotic edema was encountered in 68% and emergency tracheostomy had to be done in 15.8%. [2] Shehzad et al, in an audit at Sheikh Zaid hospital concluded that upper airway obstruction secondary to black stone poisoning is emerging as a new indication for emergency tracheostomy [5]. Another study by Aftab et al, at Nishtar Medical Hospital Multan showed that manifestations of local injury like throat pain, dysphagia, dysphonia, cervicofacial edema and stridor were the earliest findings to appear in black stone poisoning as seen in our patient [1].…”

Section: Discussionsupporting

confidence: 51%

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Black Stone Poisoning: A Case Report

Arshad¹,

Inam²,

Karim³

et al. 2017

J Clinic Toxicol

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Section: Discussionsupporting

confidence: 51%

“…Poisoning due to hair dye intake is evolving as a means of self-harm in various developing countries of Asia and Africa, mortality rates as high as 60% has been reported [1][2][3][4][5]. Paraphenylenediamine (PPD) is the constituent of hair dyes that is responsible for toxicity.…”

Section: Introductionmentioning

confidence: 99%

Black Stone Poisoning: A Case Report

Arshad¹,

Inam²,

Karim³

et al. 2017

J Clinic Toxicol

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“…Hair dyes contain paraphenylene-diamine and a host of other chemicals that can cause rhabdomyolysis, laryngeal edema, severe metabolic acidosis, and acute renal failure [20]. Snake bite-associated AKI responded well to dialysis with high rates of renal function recovery.…”

Section: Discussion In Relation To Other Studiesmentioning

confidence: 99%

Acute Kidney Injury in Sub-Sahara Africa: A Single-Center Experience from Khartoum, Sudan

Yousif¹,

Topping

Osman³

et al. 2018

Blood Purif

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Background:The burden of acute kidney injury (AKI) is high in Africa. While there are no reliable statistics about AKI in Africa, the Global Snapshot Study of the 0by25 initiative of the International Society of Nephrology has determined dehydration, infections, animal envenomation, and complications during pregnancy as the main causes. Methods: This study was conducted at the Soba University Hospital (SUH), Khartoum, Sudan, a tertiary referral center. We included all hemodialysis patients treated for AKI at SUH between January 1, 2013 and December 31, 2014 in the study. We reviewed patients' hospital records and characterized pathogenesis, treatment, and patient outcomes. In addition, we investigated survival by Kaplan-Meier and Cox regression analysis. Results: Out of 520 patients who received emergency HD, 71 patients (14%) had AKI (age 40.6 ± 17.3 years, 56.5% were males). Glomerular and tubular-interstitial diseases were the leading cause of AKI, followed by envenomation and intoxication by hair dye. Patients received a median of 5 dialysis sessions for a median of 8 days. In 32 patients (45%) renal function recovered, 10 patients (14%) died, and 29 patients (41%) remained dialysis-dependent. Mortality was significantly higher in females compared to men (hazard ratio 4.1 [95% CI 1.02-16.67]). Outcomes were worse in patients with pre-renal AKI and intoxications. Conclusion: Our results indicate a higher mortality in females and in patients with pre-renal AKI and intoxications. Awareness of factors associating with poor outcomes is central to diagnostic and therapeutic efforts, and must be considered in the design of initiatives to reduce risk factors and improve outcomes of AKI in developing countries.

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“…In a recent companion paper, we have studied the basic in vivo and in vitro pharmacological actions of PPD in a variety of animal models. Although description of clinical cases of PPD toxicity in humans (resulting mainly from suicidal attempts) have been made (Suliman et al, 1983;Brown et al, 1987;Yagi et al, 1991) little seem to have been reported on the toxic effects of PPD in laboratory animals (Kiese and Rauscher, 1968;Mascres and Jasmin, 1974;Mathur et al, 1990). Therefore, in the present work we have examined the gross and histopathological, haematological and biochemical effects of acute and subchronic administration of PPD in rats and chicks.…”

Section: Introductionmentioning

confidence: 95%

“…Several cases of accidental, homicidal and suicidal poisoning with PPD have been reported in the Sudan, where it is mainly used to intensify the black colour produced by Henna (Lawonia inermis) and to reduce the time required for dying and decorating hands and feet with Henna (El-Ansary et al, 1983;Suliman et al, 1983;Yagi et al, 1991;Abdelkarim et al, 1992). PPD has also been identified as one of the constituents of 'home made' analgesic remedies prepared by local "witch doctors' (Averbukh et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Some Toxicological Observations on Paraphenylene Diamine (Hair Dye) in Rats and Chickens

Saad¹,

.²,

Ali³

2000

Pakistan J. of Biological Sciences

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Paraphenylene diamine (PPD) is commonly used in the Sudan as hair dye and to intensify Henna colour. Several cases of poisoning with this compound have been reported in humans. Therefore, in the present work, we have examined the haematological, pathological and biochemical actions of PPD in rats and chickens. We also attempted to extract and detect PPD in tissues from treated rats and chickens. The toxic effects of PPD were qualitatively similar in the two species, but the onset of toxicity was faster and incidence of mortality higher in rats than in chickens. The clinical signs of toxicity included anorexia, decreased mobility, hind leg weakness and death. Histopathologically, PPD caused congestion, fatty change and necrosis in the liver, kidney, heart and muscles. This was accompanied by significant increases in plasma enzymes and metabolites indicative of tissue damage. Haematologically, there was also significant decreases in the packed cell volume, haemoglobin and erythrocytes counts. PPD could not be detected in the tissues of treated animals, probably suggesting that metabolite(s) of PPD and not the parent compound were responsible for the toxicity.

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Paraphenylenediamine Induced Acute Tubular Necrosis Following Hair Dye Ingestion

Abstract: 1 A case is reported of paraphenylenediamine toxicity following hair dye ingestion. 2 Renal biopsy showed histology typical of acute tubular necrosis.

Cited by 31 publications

References 3 publications

Black Stone Poisoning: A Case Report

Black Stone Poisoning: A Case Report

Acute Kidney Injury in Sub-Sahara Africa: A Single-Center Experience from Khartoum, Sudan

Some Toxicological Observations on Paraphenylene Diamine (Hair Dye) in Rats and Chickens

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