Paraoxonase1 activity, its Q192R polymorphism and diabetic retinopathy in type 2 diabetes mellitus.

Correlation Between Serum PON1 Arylesterase Activity and Rs 854573 <i>PON1 A < G</i> Polymorphism with Type 2 Diabetes in an Eastern Indian Cohort

“…Determination of PON1 activity has been done not only in different oxidative stress related diseases but also in different ethnic groups (Gupta et al, 2011, 19). Serum PON1-HCTLase and PON1-AREase activity were reported to be significantly lowered in DM (Boemi et al, 2001;21;Hampe and Mogarekar, 2014;36;MacKness et al, 2000;22;Sonoki et al, 2009;23;Wheeler et al, 2004, 20). Similar reduction of serum PON1 activities in asthma patients with elevated PON1 protein expression of lung tissue in control experimental mice, were reported [45].…”

“…PON1 SNPs have strong contribution on worldwide association studies especially in diabetes and oxidative stress related diseases. A numbers of different SNPs like an amino acid substitution at position 192 (Q192R) polymorphism or coding region L55M polymorphisms have been found to be associated with DM and CAD patients in different Indian populations [19,35], or in Turkish DM populations [36,37]. T2DM patients with LL genotype (rs 854560 L55M) were found to have an increased risk of CAD and retinopathy [38,39].…”