Paraoxonase and Superoxide Dismutase Gene Polymorphisms and Noise-Induced Hearing Loss

Fortunato, Giuliana; Marciano, Elio; Zarrilli, Federica; Mazzaccara, Cristina; Intrieri, Mariano; Calcagno, Giuseppe; Vitale, Dino Franco; Manna, P La; Saulino, Claudio; Marcelli, Vincenzo; Sacchetti, Lucia

doi:10.1373/clinchem.2004.037788

Cited by 96 publications

(75 citation statements)

References 36 publications

(34 reference statements)

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“…[13] However, no study has examined the serum PON levels of patients with ISSHL. We found no significant difference between the pretreatment serum anti-HSP70 levels of the study and control groups.…”

Section: Discussionmentioning

confidence: 99%

“…[6,[7][8][9][10][11][12] One study found an association between a PON2 gene polymorphism and SHL and postulated that it could represent a marker of susceptibility to noise-induced hearing loss. [13] As mentioned, few studies have evaluated the relationship between anti-HSP70 levels and the prognosis of ISSHL patients. In addition, no study has directly investigated the correlation between serum PON activity and hearing loss.…”

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confidence: 99%

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Prognostic value of serum anti-heat-shock protein 70 and paraoxonase levels in idiopathic sudden sensorineural hearing loss

Düzer¹

2014

Kulak Burun Bogaz Ihtis Derg

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Objectives: This study aims to investigate the correlation between serum anti-heat-shock protein 70 (anti-HSP 70) levels, serum paraoxonase (PON) levels and prognosis of idiopathic sudden sensorineural hearing loss (ISSHL). Patients and Methods:Twenty-five patients with ISSHL as the study group and 25 healthy volunteers as the control group were enrolled in this study. Blood samples were obtained from all patients before the treatment initiation and on the 10 th day of the treatment from only patients of the study group. Idiopathic sudden sensorineural hearing loss was defined as the hearing loss between 250-6.000 Hz frequencies. The recoveries in the hearing thresholds were evaluated at 10 days of the treatment.Results: When the pre-treatment serum PON, anti-HSP 70 levels and the post-treatment serum PON, anti-HSP 70 levels of the patients with ISSHL were compared, we observed that the post-treatment serum PON levels of the recovered patients increased, while the post-treatment serum anti-HSP 70 levels of recovered patients decreased. Conclusion:We believe that serum levels of anti-HSP 70 and PON can be used as markers for estimating and evaluating the prognosis of ISSHL patients.Key Words: Heat-shock protein 70; idiopathic sudden sensorineural hearing loss; paraoxonase; prognosis.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Prognostic value of serum anti-heat-shock protein 70 and paraoxonase levels in idiopathic sudden sensorineural hearing loss

Düzer¹

2014

Kulak Burun Bogaz Ihtis Derg

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“…Male workers from an aircraft factory were enrolled a study in which SOD polymorphism was studied. 24 Even if there was some obstacles like small sample size and the difficulty in matching cases to controls, the data suggest Mn-SOD (SOD2) polymorphism could predispose to noiseinduced hearing loss. The other study was conducted by Chang et al in which the distribution of Mn-SOD genetic polymorphisms IVS3-23T/G on noise susceptibility in Asians were investigated.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Noise on Oxidative and Antioxidative Balance in Human Erythrocytes

Pınar¹,

Atlı²,

Alaçam³

et al. 2011

UHOD

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Reactive oxygen and nitrogen species have been implicated in the pathogenesis of noise-induced hearing loss. In this case-control study, we investigated the oxidative and antioxidative status of erythrocytes from workers in noisy workplace. Blood samples of 127 workers in noisy workplace (WNW) and 117 workers in non-noisy workplace (WNNW) from the same company were taken into tubes with potassium EDTA as anticoagulant in order to obtain hemolysate. Total superoxide dismutase (SOD) and catalase (CAT) activities as the enzymes of antioxidative defense mechanism in the erythrocytes together with malondialdehyde (MDA) as the lipid peroxidation index and total nitric oxide (NO) as an index for nitrogen species analyses were performed by spectrophotometric methods. SOD activity was found to be 450.0±106.4 U/g Hb in WNW and 443.1±83.1 U/g Hb in WNNW. The difference between two groups were not statistically significant (p= 0.582). CAT activity was found to be 426.0±98.0 k/g Hb in WNW and 432.6±109.0 k/g Hb in WNNW showing statistically insignificant difference (p= 0.621). MDA levels in erythrocytes from WNW was significantly higher than WNNW (39.28±10.22 nmol/g Hb and 32.51±10.73 nmol/g Hb, respectively and p= 0.0001). On the other hand, NO levels were found to be significantly reduced in WNW (0.275±0.187 µmol/g Hb) compared to WNNW (0.382±0.284 µmol/g Hb) (p= 0.001). When we analyzed the hematological parameters, all the cell counts increased in WNW except monocytes and platelets compared to WNNW (p= 0.0001). Related to this changes, hemoglobin, MCHC, and hematocrit also increased in WNW (p= 0.0001). The oxidative stress, which is possibly propagated by the physical environment, seems to have an important pathophysiological role in hearing loss and lipid peroxidative cellular changes in all of the workers who work in noisy occupations.Key words: Noise, Worker, Oxidative stress, Superoxide dismutase, Catalase, Malondialdehyde, Nitric oxide ÖZET Gürültünün ‹nsan Eritrositlerindeki Oksidan ve Antioksidan Dengeye EtkileriReaktif oksijen ve nitrojen türleri, yüksek ses kaynakl› duyma kay›plar›nda önemli bir patolojik faktör olarak kabul görmekte-dir. Bu vaka kontrollü çal›flmam›zda yüksek sesli ortamlarda çal›flan iflçilerin eritrositlerinde oksidan ve antioksidan dengeyi araflt›rd›k. Yüksek sesli ortamda çal›flan (YSOÇ) 127 iflçi ile normal ortamda çal›flan (NOÇ) 117 iflçinin kanlar› hemolizat elde etmek üzere içinde antikoagulan olarak potasyum EDTA bulunan tüplere al›nd›.

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“…Impaired function of antioxidant enzymes caused by genetic variation has been postulated as leading to failure of cellular responses against the toxic effects of ROS and subsequent peroxidative cell injury. Studies of knock-out models of Gpx1 and Sod1 have shown that deletion in the two antioxidant genes can lead to both age-related and noise-induced HL [51][52][53]. These mice show the phenotypic characteristics of ARHL.…”

Section: Oxidative Stressmentioning

confidence: 99%

Ageing and hearing loss

Yan

2007

The Journal of Pathology

266

178

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Although many adults retain good hearing as they age, hearing loss associated with ageing is common among elderly persons. There are a number of pathophysiolological processes underlying age-related changes to functional components in the inner ear. Genetic factors determine the ageing process but are under the influence of intrinsic and environmental factors. It is difficult to distinguish changes of normal ageing from those of other contributing factors. The effects of age-related deafness can have significant physical, functional and mental health consequences. Although a deficit in hearing can be corrected to some degree by a hearing aid or other appropriate amplification devices, hearing-related rehabilitative needs are much more than simply amplifying external sound. Only by better understanding the process of ageing and its effect on the auditory function can we better accommodate elderly people in our day-to-day interactions. We review here the structure and function of the inner ear, pathophysiology associated with age-related hearing loss (ARHL), heritability, allelism and modifier genes of ARHL, and evaluate the genetic analyses for identification of genetic factors that are involved.

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Paraoxonase and Superoxide Dismutase Gene Polymorphisms and Noise-Induced Hearing Loss

Cited by 96 publications

References 36 publications

Prognostic value of serum anti-heat-shock protein 70 and paraoxonase levels in idiopathic sudden sensorineural hearing loss

Prognostic value of serum anti-heat-shock protein 70 and paraoxonase levels in idiopathic sudden sensorineural hearing loss

The Effects of Noise on Oxidative and Antioxidative Balance in Human Erythrocytes

Ageing and hearing loss

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