Paraoxonase and arylesterase activity in bladder cancer

Utanğaç, Mehmet Mazhar; Yeni, Ercan; Savaş, Murat; Altunkol, Adem; Çiftçi, Halil; Gümüş, Kemal; Demir, Mehmet Emin

doi:10.5152/tud.2017.89411

Cited by 18 publications

(11 citation statements)

References 27 publications

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“…PON1 and PON3 are localised in the plasma, whereas PON2 is in the plasma membrane, endoplasmic reticulum, nuclear envelop and inner mitochondrial membrane [ 74 , 102 , 103 , 104 ]. The patients with diagnosed BC characterised the decreased activity of PON1 in serum compared to the control group [ 71 ]. Moreover, these patients showed a low concentration of PON1 in serum as compared to controls, which were associated with a higher level of the chemokine (CC motif) ligand 2 C-reactive protein.…”

Section: Oxidative Stress and Bladder Cancermentioning

confidence: 99%

The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development

Wigner

Grębowski

Bijak

et al. 2021

IJMS

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In 2018, 550,000 people were diagnosed with bladder cancer (BC), of which nearly 200,000 people died. Moreover, men are 4 times more likely than women to be diagnosed with BC. The risk factors include exposure to environmental and occupational chemicals, especially tobacco smoke, benzidine and genetic factors. Despite numerous studies, the molecular basis of BC development remains unclear. A growing body of evidence suggests that inflammation, oxidant-antioxidant imbalance and angiogenesis disorders may play a significant role in the development and progression of bladder cancer. The patients with bladder cancer were characterised by an increased level of reactive oxygen species (ROS), the products of lipid peroxidation, proinflammatory cytokines and proangiogenic factors as compared to controls. Furthermore, it was shown that polymorphisms localised in genes associated with these pathways may modulate the risk of BC. Interestingly, ROS overproduction may induce the production of proinflammatory cytokines, which finally activated angiogenesis. Moreover, the available literature shows that both inflammation and oxidative stress may lead to activation of angiogenesis and tumour progression in BC patients.

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Section: Oxidative Stress and Bladder Cancermentioning

confidence: 99%

The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development

Wigner

Grębowski

Bijak

et al. 2021

IJMS

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“…In the literature, PON1 has been investigated in selected human neoplasms, reporting lower enzyme activity in the patients with lung, breast, colorectal, esophageal, or bladder cancer compared to the well-matched control groups, in general. 11–14 In a study of Samra et al, 15 low serum PON/arylesterase activity as well as high lipid peroxide levels was reported in all cancer patients. However, there are also opposite results published.…”

Section: Introductionmentioning

confidence: 97%

Serum paraoxonase 1 activity and protein N-homocysteinylation in primary human endometrial cancer

et al. 2018

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Paraoxonase 1 plays an important role in protection from oxidative stress and also decomposes homocysteine thiolactone, the toxic metabolite of homocysteine. A limited number of reports evaluated the role of paraoxonase 1 in women affected by female genital tract neoplasms, including endometrial cancer. This study aimed to analyze the paraoxonase activity in the group of endometrial cancer patients (n = 48) who underwent primary surgery and to compare the data available with a well-matched control group (n = 30). Due to the role of paraoxonase 1 in the metabolism of homocysteine (Hcy) thiolactone, the amount of Hcy-thiolactone as well as total serum Hcy concentrations was also measured. Serum paraoxonase 1 activity toward synthetic substrates, paraoxon and phenyl acetate, in the study group was significantly lower compared to the control one. The mean paraoxonase 1 activity toward homocysteine thiolactone tended to be lower in the endometrial cancer group but this difference was not significant. There was no relationship between endometrial cancer and Q192R polymorphism of PON1 assessed by the dual substrate method. No differences in paraoxonase 1 activity between endometrial cancer subgroups according to clinico-pathological features were detected. Total serum homocysteine and protein-bound homocysteine thiolactone did not differ between control and cancer groups. In conclusion, reduced paraoxonase 1 activity suggests diminished important antioxidant mechanisms during the development of primary endometrial cancers in humans. PON1 Q192R polymorphism is not associated with the risk of endometrial cancer. Despite lower paraoxonase 1 activity, homocysteine concentration, and protein N-homocysteinylation in endometrial cancers do not differ from matched controls.

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“…PON1 activities could be evaluated using different substrates including paraoxon (PON1 paraoxonase activity) and phenyl-acetate (PON1 arylesterase activity). PON1 paraoxonase and arylesterase activities were significantly decreased in the serum of BC subjects with respect to controls [47].…”

Section: Cellular and Extracellular Antioxidant Enzymesmentioning

confidence: 99%

“…A deregulation of oxidative/antioxidant balance in bladder cancer is also suggested by the significant modifications of total antioxidant status (TAS) and total oxidant status (TOS) in the serum of BC subjects. The TAS indicates the overall antioxidative status of the serum, while the TOS denotes the oxidative status of the serum [33, 40, 47]. The significant decrease of the oxidative stress index (OSI) calculated as the ratio between TOS and TAS values confirms that BC is associated with oxidative stress [47].…”

Section: Markers Of Lipid Protein and Nucleic Acid Oxidative Strmentioning

confidence: 99%

Alterations of Antioxidant Enzymes and Biomarkers of Nitro-oxidative Stress in Tissues of Bladder Cancer

Islam

Bacchetti

Ferretti

2019

Oxidative Medicine and Cellular Longevity

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Bladder cancer (BC) is one of the most common tumors found in the urinary bladder for both male and female in western countries. In vitro and in vivo studies suggest that high levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and oxidative stress play a crucial role in human cancer. Low concentration of ROS and RNS is indispensable for cell survival and proliferation. However, high concentration of ROS and RNS can exert a cytotoxic effect. Increased oxidative stress is a result of either increased ROS/RNS production or a decrease of antioxidant defense mechanisms. A literature search was carried out on PubMed, Medline, and Google Scholar for articles in English published up to May 2018 using the following keywords: oxidative stress, antioxidants, reactive oxygen species, lipid peroxidation, paraoxonase, urinary bladder cancer, and nitric oxide. Literature data demonstrate that BC is associated with oxidative stress and with an imbalance between oxidants and antioxidant enzymes. Markers of lipid peroxidation, protein and nucleic acid oxidation are significantly higher in tissues of patients with BC compared with control groups. A decrease of activity of antioxidant enzymes (superoxide dismutase, catalase, glutathione, and paraoxonase) has also been demonstrated. The imbalance between oxidants and antioxidants could have a potential role in the etiology and progression of bladder cancer.

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Paraoxonase and arylesterase activity in bladder cancer

Cited by 18 publications

References 27 publications

The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development

The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development

Serum paraoxonase 1 activity and protein N-homocysteinylation in primary human endometrial cancer

Alterations of Antioxidant Enzymes and Biomarkers of Nitro-oxidative Stress in Tissues of Bladder Cancer

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