Paraoxonase activity in healthy, diabetic, and hemodialysis patients

Gbandjaba, Nagba Yendoubé; Ghalim, Noreddine; Hassar, Mohamed; Berrougui, Hicham; Labrazi, Halima; Hassan, Taimur; Saı̈le, Rachid; Khalil, Abdelouahed

doi:10.1016/j.clinbiochem.2012.01.005

Cited by 29 publications

(32 citation statements)

References 35 publications

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“…Despite our findings regarding the reverse epidemiology for the mortality of HD patients, further studies are needed to reveal the real effects of nutritional state on atherosclerosis in obese and malnourished CKD patients. There is growing evidence in the literature [42,43] to support our initial hypothesis that the antioxidant properties of PON-1 enzyme are closely associated with PON1 paraoxonase activity and not with lactonase activity. Therefore, in the present study we have primarily investigated the relationship between PON1 paraoxonase activity and the antioxidant status in chronic kidney disease depending on nutritional status.…”

Section: Resultsmentioning

confidence: 69%

Effect of Nutritional Status on Human Paraoxonase-1 Activity in Patients with Chronic Kidney Disease

Sztanek

Serés

Harangi

et al. 2012

Kidney Blood Press Res

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Background/Methods: The association between nutritional status, antioxidant human paraoxonase-1 (PON1) activity and low grade inflammation in hemodialized (HD) patients with chronic kidney disease (CKD) is unclear. The aim of this study was to determine PON1 paraoxonase and lactonase activities, ADMA, adiponectin and leptin concentrations, and to clarify the relationship between paraoxonase activity and a set of cardiovascular risk factors in malnourished, normal weight and obese HD patients; 114 HD patients with end-stage renal failure were enrolled. Results: Leptin levels were significantly higher and PON1 paraoxonase activities were significantly lower in obese patients compared to the other groups. Plasma adiponectin concentration was significantly lower in obese subjects compared to malnourished patients. Paraoxonase activity was negatively correlated with CRP level in HD and malnourished patients. Furthermore, we found significant inverse correlation between paraoxonase activity and BMI in the whole patient group. In multiple regression analysis, PON1 lactonase activity, CRP level and leptin concentration proved to be independent predictors of paraoxonase activity. Conclusion: Despite the previous findings of reverse epidemiology for the mortality rate of HD patients, further studies are needed to clarify the effects of nutritional state on atherosclerosis in obese and malnourished patients with end-stage renal failure.

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Section: Resultsmentioning

confidence: 69%

Effect of Nutritional Status on Human Paraoxonase-1 Activity in Patients with Chronic Kidney Disease

Sztanek

Serés

Harangi

et al. 2012

Kidney Blood Press Res

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“…PON1 inactivation was shown upon its incubation with oxidized LDL [20], or oxidized glutathione [21], as well as under high fat, high cholesterol diets, in hemodialysis patients [4,22], and under acute-phase response. Similarly, inhibition of PON1 activity has also been reported in smokers who show a reduction in the number of PON1 free sulfhydryl groups.…”

Section: Regulators Of Paraoxonasementioning

confidence: 99%

“…PON3, Like PON1, is found in liver cells and in plasma at a concentration of about two orders of magnitude lower than that of PON1. PON1, 2, and 3 have all been shown to protect against oxidative stress, and to inhibit macrophage foam cell formation and atherogenesis [4,5]. The present review focuses on PON1 mutual interactions with small molecules in its milieu, with a special emphasis on those present in human atherosclerotic lesions.…”

Section: Introductionmentioning

confidence: 99%

Paraoxonase 1 activities, regulation, and interactions with atherosclerotic lesion

Aviram

Vaya

2013

Current Opinion in Lipidology

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“…PON1 exerts both paraoxonase and arylesterase activities (ARE), since the enzyme hydrolyzes organophosphates (such as paraoxon) and hydrolyze aromatic esters (such as phenyl acetate) [9, 10]. It was reported that, related to ROS attack, PON1 and ARE enzyme levels and/or activity were decreased in states of high oxidative stress like diabetes, coronary artery disease, and dyslipidemia [11–13]. Some authors suggested that administration of antioxidants could protect PON1 from inactivation and/or diminishment arising from ROS and consequently ameliorate diabetes and related complications [14–16].…”

Section: Introductionmentioning

confidence: 99%

Vitamin B6 Supplementation Improves Oxidative Stress and Enhances Serum Paraoxonase/Arylesterase Activities in Streptozotocin-Induced Diabetic Rats

Taş

Sarandöl

Dirican

2014

The Scientific World Journal

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The purpose of this study was to investigate the effects of vitamin B6 (Vit B6) on oxidant and antioxidant status in streptozotocin-induced diabetic rats. Thirty-two Wistar rats were divided into four groups: control (C), control + Vit B6 group (C + Vit B6), diabetes (D), and diabetes + Vit B6 group (D + Vit B6). Vit B6 (4 mg/kg body weight) was administered in drinking water for 4 weeks after the induction of diabetes. Vitamin B6 reduced serum total cholesterol level in the C + Vit B6 (P < 0.01) and D + Vit B6 (P < 0.05) groups. Plasma and tissue malondialdehyde levels were reduced in the C + Vit B6 and D + Vit B6 groups. Whole blood glutathione peroxidase (GSH-Px) and erythrocyte superoxide dismutase (SOD) activities were higher in the D group (P < 0.05). GSH-Px and SOD activities were increased in C + Vit B6 group while these parameters decreased in the D + Vit B6 group. Paraoxonase and arylesterase activities were decreased in the D group while they were increased in C + Vit B6 and D + Vit B6 groups. The results of present study suggest that vitamin B6 supplementation might be a promising adjunctive agent for improving oxidative stress and metabolic disturbances and for preventing diabetic complications including atherogenesis.

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Paraoxonase activity in healthy, diabetic, and hemodialysis patients

Cited by 29 publications

References 35 publications

Effect of Nutritional Status on Human Paraoxonase-1 Activity in Patients with Chronic Kidney Disease

Effect of Nutritional Status on Human Paraoxonase-1 Activity in Patients with Chronic Kidney Disease

Paraoxonase 1 activities, regulation, and interactions with atherosclerotic lesion

Vitamin B6 Supplementation Improves Oxidative Stress and Enhances Serum Paraoxonase/Arylesterase Activities in Streptozotocin-Induced Diabetic Rats

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