Paraoxonase: A multifaceted biomolecule

Goswami, Binita; Tayal, Devika; Gupta, Nikhil; Mallika, V.

doi:10.1016/j.cca.2009.09.025

Cited by 125 publications

(103 citation statements)

References 141 publications

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“…The PON1 gene contains two common polymorphisms found in the PON1 coding region, leading to a glutamine (Q) → arginine (R) substitution at position 192 (Q192R; rs 662) and to a leucine(L) → methionine (M) substitution at position 55 (L55M; rs 854560) 9 . The L55M polymorphism affects the enzyme concentration and the Q192R polymorphism is responsible for the hydrolytic activity of the enzyme 10,11 . Studies concerning the relationship between PON1 polymorphism and mood disorders exhibited inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder

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et al. 2017

Arch. Clin. Psychiatry (São Paulo)

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Background: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play an important role in the pathogenic mechanisms underlying major depression and bipolar disorder. Objective: The aim of the present study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patients with major depression and bipolar affective disorder. Methods: PON1 L55M and Q192R single nucleotide polymorphisms were analyzed in a group consisted of 100 patients with major depression, and 100 patients with bipolar affective disorder and 96 healthy controls. Polymorphisms were analyzed by using polymerase chain reaction. Results: Our findings reported no association between Q192R and L55M polymorphisms of PON1 and major depression and bipolar disorder. Additionally, there was no association between the PON1 genotypes and disease variables in both depressed and bipolar patients. Discussion: Evaluating the different stages of patients with affective disorders and and investigating the connection between PON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders.

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Section: Introductionmentioning

confidence: 99%

Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder

Yıldız

Celikel

Ateş

et al. 2017

Arch. Clin. Psychiatry (São Paulo)

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“…Diversos estudios clínicos encontraron una menor actividad sérica de la paraoxonasa en pacientes con enfermedad cardiovascular y con enfermedades que presentan elevado estrés oxidativo, como la diabetes, síndrome metabólico (SM), procesos inflamatorios, entre otras (7) .…”

Section: Introductionunclassified

“…Asimismo, algunos estudios de casos y controles sobre el polimorfismo del gen PON1192 sugieren una correlación con enfermedad de las arterias coronarias, infarto, hipercolesterolemia familiar, diabetes tipo 2, y la enfermedad de Parkinson (7) . Serrato et al (9) mostraron que los pacientes con enfermedad coronaria arterial presentaban una mayor frecuencia del alelo R del polimorfismo PON1 192 que la población general.…”

Section: Introductionunclassified

Evaluación comparativa del nivel de control del asma bronquial en pacientes de 12 a 17 años de edad de EsSalud Arequipa

2017

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RESUMENObjetivo: La paraoxonasa 1 (PON1), una esterasa asociada a las lipoproteínas de alta densidad (HDL), presenta diversos polimorfismos: el polimorfismo PON1 Q192R (región codificante) es el responsable de las variaciones de la actividad paraoxonasa de la enzima. El alelo PON1 192R es considerado un factor de riesgo para desarrollar trastornos cardiometabólicos en algunas poblaciones. El objetivo del presente estudio es determinar la distribución de los polimorfismos PON1 Q192R, y su asociación con el perfil lipidíco y APO A1 en una población andina. Materiales y métodos: Estudio descriptivo, transversal, en el que participaron 79 personas adultas (26 hombres y 53 mujeres), clínicamente sanas, residentes del distrito de Junín a 4105 msnm. Se empleó la técnica PCR/RFLP para el análisis del sitio polimórfico Q192R del gen PON1, y se determinaron los valores séricos del perfil lipídico y APO A1, y las actividades paraoxonasa y arilesterasa de la enzima. Resultados: La distribución de los genotipos para PON1192 fue: QQ 13,9%, QR 45,6% y RR 40,5%, y el alelo más frecuente fue 192R 63%. Las actividades paraoxonasa basal y estimulada fueron diferentes según sus genotipos, mientras que la actividad esterasa de la enzima no estuvo influenciada por el polimorfismo. Por otra parte, no se encontró asociación entre el polimorfismo PON1 Q192R y el perfil lipídico y APO A1. Conclusiones: La alta prevalencia del alelo PON1 192R en la población estudiada probablemente indique un papel importante en el desarrollo de enfermedades cardiometabólica.Palabras clave: Paraoxonasa; polimorfismo; factores de riesgo cardiovascular; altitud. Distribution of the Q192R polymorphism of the paraoxonase 1 gene in a population of the district of Junín (Junín region, Peru)ABSTRACT Objective: Paraoxonase 1 (PON1), an esterase associated with high-density lipoproteins (HDL), has several polymorphisms: the PON1 Q192R polymorphism (coding region) is responsible for variations in the paraoxonase activity of the enzyme. The PON1 192R allele is considered a risk factor for developing cardiometabolic disorders in some populations. The aim of the present study is to determine the distribution of the PON1 Q192R polymorphism and its association with the lipid profile and APO A1 in an Andean population. Materials and methods: A descriptive, cross-sectional study involving 79 healthy adults (26 males and 53 females), residents of the district of Junín at 4105 m.a.s.l. The PCR/RFLP technique was used for the analysis of the PON1 Q192R polymorphism. The serum values of the lipid profile and APO A1, and the paraoxonase and arylesterase activities of the enzyme were determined. Results: The distribution of the genotypes for PON1192 was QQ 13.9%, QR 45.6% and RR 40.5%, and the most frequent allele was 192R 63%. The baseline and stimulated paraoxonase activities were different based on their genotypes, while the esterase activity of the enzyme was not influenced by the polymorphism. On the other hand, no association was found between the PON1 Q192R polymorphism ...

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“…Após a sua descoberta, a PON tem sido objeto de estudo em diversos campos de pesquisa (Van Himbergen et al, 2006;Goswami et al, 2009). Assim, a família PON pode estar associada a inúmeros eventos fisiopatológicos como doença aterosclerótica coronariana (Pérez-Herrera et al, 2008;Shin, 2009;Précourt et al, 2011), síndrome metabólica (Flekac et al, 2008;Kordi-Tamandani et al, 2011) e distúrbios neurológicos (Lawlor et al, 2007;Kucukali et al, 2008).…”

Section: Paraoxonase (Pon)unclassified

“…Além disso, esses mesmos polimorfismos associam-se com inúmeras condições patofisiológicas (Goswami et al, 2009;Hussein et al, 2011;Rajković et al, 2011 (Ng et al, 2005).…”

Section: Pon1 E Hdlunclassified

Estudo das paraoxonases 1, 2 e 3 em pacientes portadores de anemia falciforme"

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Paraoxonase: A multifaceted biomolecule

Cited by 125 publications

References 141 publications

Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder

Paraoxonase (PON1) L55M and Q192R polymorphisms in major depression and bipolar affective disorder

Evaluación comparativa del nivel de control del asma bronquial en pacientes de 12 a 17 años de edad de EsSalud Arequipa

Estudo das paraoxonases 1, 2 e 3 em pacientes portadores de anemia falciforme"

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